Tropheryma whipplei Twist: TWT_586
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Entry
TWT_586 CDS
T00116
Symbol
folPXK
Name
(GenBank) dihydropteroate synthase/dihydroneopterin aldolase/2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase fusion protein
KO
K00796
dihydropteroate synthase [EC:
2.5.1.15
]
K00950
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:
2.7.6.3
]
K01633
7,8-dihydroneopterin aldolase/epimerase/oxygenase [EC:
4.1.2.25
5.1.99.8
1.13.11.81
]
Organism
twh
Tropheryma whipplei Twist
Pathway
twh00790
Folate biosynthesis
twh01100
Metabolic pathways
twh01240
Biosynthesis of cofactors
Brite
KEGG Orthology (KO) [BR:
twh00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
TWT_586 (folPXK)
Enzymes [BR:
twh01000
]
1. Oxidoreductases
1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
1.13.11 With incorporation of two atoms of oxygen
1.13.11.81 7,8-dihydroneopterin oxygenase
TWT_586 (folPXK)
2. Transferases
2.5 Transferring alkyl or aryl groups, other than methyl groups
2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
2.5.1.15 dihydropteroate synthase
TWT_586 (folPXK)
2.7 Transferring phosphorus-containing groups
2.7.6 Diphosphotransferases
2.7.6.3 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
TWT_586 (folPXK)
4. Lyases
4.1 Carbon-carbon lyases
4.1.2 Aldehyde-lyases
4.1.2.25 dihydroneopterin aldolase
TWT_586 (folPXK)
5. Isomerases
5.1 Racemases and epimerases
5.1.99 Acting on other compounds
5.1.99.8 7,8-dihydroneopterin epimerase
TWT_586 (folPXK)
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pterin_bind
HPPK
FolB
DUF2824
Phospholip_A2_4
Motif
Other DBs
NCBI-ProteinID:
AAO44683
UniProt:
Q83FV9
LinkDB
All DBs
Position
complement(674213..676513)
Genome browser
AA seq
766 aa
AA seq
DB search
MMNMSYTPDPFPPPNVMGILNITDDSFSDGGLFLDPSAAITQGRKLFAEGASIIDVGGES
TRPGAERISVEEEKKRVLPVVRELLSEGIHVSLDTMNADTAKEGLSMGVAIINDVSAGKA
DPDMLRVIADAGCKYIAMHWRGHSMFMDSLAHYDDVVSDVLRELKFDIERITAAGVKSDQ
IILDPGFGFSKTSDHNWQLFRNLDCFVKLGFPVLIGLSRKRFLSRVFKGHDFSPKDSKNV
GGLDNREILARDLPSGILSAIAITRGAWGVRVHDVASAHTALRTLQLAQYGSVYQAHKRA
ANTGIDTAIPGQGNTDDTTASSNHTNNSETGASLKSGVSQVRNMIAPPVIKIRSLRVYAY
HGVYRSERDYGQQFIIDADIQLKHFPEDKIDSTLDYDSLTGKFVQYATASSVNLIETLAD
HLAKIAVLDPMVEWVSLSITKPNPPLAYMKQSNTAACHAMHKPDTRGDYAKEHTNLTGLQ
LSCTVRKVRSESVTRVYIGIGANVGNCLDNVQRAIKDIADHPMIELVSLGRLFRTTAVVG
ESLDESLPVFLNTAIAIDTALSMQDLLALMLCIEKKLGRTRHSRTRHSLSSAQDAHQADS
TSDNPNQLHYPCAGRQGIQQPLHSSTLAHTQDGFVNRHIDLDILLAEGVQITEHGLCIPH
PRLSKRAFALLPLESIDPDLHIPGHGPITDLIHGLPEDQISSVATLRDSGYELFRHSITR
LNNCSAHNKAYVTPSAGQNYDSEQDFDAGLSHTESRGKTEPHGKYE
NT seq
2301 nt
NT seq
+upstream
nt +downstream
nt
gtgatgaacatgagctatactcccgacccatttccacctcctaatgtaatgggcattctg
aatataaccgatgattctttcagtgatggtggactgtttttagacccctctgctgccatt
acccaaggtagaaagttatttgctgagggtgcttcaataatcgatgttgggggtgaatcg
acacgcccgggtgctgagcggattagcgtggaagaagaaaaaaaaagggttttacccgta
gttagggaacttctatccgaaggtattcatgtaagtcttgacaccatgaatgcagacaca
gcaaaagagggccttagcatgggtgttgccattataaatgacgtatcagcgggcaaagcc
gacccggacatgctaagagtgatagccgatgcaggctgtaaatacatcgcgatgcattgg
cgtgggcactccatgtttatggatagccttgctcattacgacgatgttgtgagtgatgtt
cttcgagagcttaagtttgatatcgagcgtattactgccgctggggtaaagagcgaccag
atcatccttgatcctggttttggcttttctaaaacaagtgaccataattggcagttgttc
agaaaccttgattgctttgttaagctgggctttcccgtgctgattggtctttcgcgcaag
aggtttttgagtcgagtatttaaggggcatgatttttctcctaaagattctaagaatgtt
ggagggttggataaccgcgaaatacttgcgcgcgatctgccaagcgggatactgagtgct
attgccataacacgtggagcatggggcgtgcgtgtacatgatgttgcctcagctcacacg
gcgctgcggactctacagcttgcgcaatacggctcggtatatcaggcccacaaacgggcg
gcaaataccggaatagacaccgcaatacccggccaaggcaacactgatgacaccactgcc
tccagtaaccacaccaacaattctgaaacaggagcttctttaaaaagtggcgtgagtcaa
gtccgcaacatgattgccccgcccgttataaagataagaagtctgcgcgtgtatgcatat
catggggtgtatcgttctgagcgggactacggtcagcaattcattatcgatgcagatatt
caattaaaacattttccagaagacaagattgactcaaccctagactatgactcattgact
ggaaagtttgtgcaatatgccaccgcatcatctgtgaatcttattgagacactcgctgat
caccttgcaaagattgccgtcctagatccaatggttgagtgggtaagcctcagcataaca
aagccaaaccctccgctcgcttatatgaaacaaagtaacacagccgcctgtcatgctatg
cataaacctgataccagaggtgattatgctaaagaacacacaaatcttacaggccttcaa
ttatcgtgcacggttaggaaagtgcgttccgaaagtgtaacaagggtctatataggcatc
ggtgcaaatgtaggtaattgcctggataatgtccagcgcgcgatcaaggatattgcagat
catccaatgattgaacttgtctcactcggcaggcttttccgaaccaccgccgttgttggc
gagagtcttgatgaatctctaccggtatttttgaatactgcaatcgcaatcgatactgct
ttatccatgcaggatttgcttgccttaatgctttgtatagagaaaaagcttggaagaact
cgtcacagtagaactcgtcacagtttatcttccgctcaagacgcccaccaggctgattca
actagcgataatcctaaccagttacattatccttgtgccggacgccaaggcatccaacag
cctttacattcgtcaactttggcgcacactcaggatgggtttgttaatcggcatattgac
cttgatatcctgctcgcggagggggttcaaattactgaacacgggttatgtattccacat
ccaaggctcagtaagagagcctttgcgcttttgccacttgagagtatagatcctgatctg
catatccccggacatggcccaattactgacttgatacatggtcttcctgaggatcaaata
agctctgttgctacccttcgagattccgggtatgaattattcaggcactctattaccaga
ctaaacaattgttcagcgcataataaagcgtatgttactccgtcagcgggccagaattat
gattctgaacaggattttgatgctggattgtcacacacagaatcacgcggaaaaacagag
ccacacggaaaatatgaataa
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