Ursus arctos (brown bear): 113243095
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Entry
113243095 CDS
T05909
Symbol
RET
Name
(RefSeq) proto-oncogene tyrosine-protein kinase receptor Ret
KO
K05126
proto-oncogene tyrosine-protein kinase Ret [EC:
2.7.10.1
]
Organism
uah
Ursus arctos horribilis (North American brown bear)
Pathway
uah04010
MAPK signaling pathway
uah04020
Calcium signaling pathway
uah04151
PI3K-Akt signaling pathway
uah05200
Pathways in cancer
uah05216
Thyroid cancer
uah05223
Non-small cell lung cancer
uah05230
Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:
uah00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
113243095 (RET)
04020 Calcium signaling pathway
113243095 (RET)
04151 PI3K-Akt signaling pathway
113243095 (RET)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
113243095 (RET)
05230 Central carbon metabolism in cancer
113243095 (RET)
09162 Cancer: specific types
05216 Thyroid cancer
113243095 (RET)
05223 Non-small cell lung cancer
113243095 (RET)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
uah01001
]
113243095 (RET)
Enzymes [BR:
uah01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
113243095 (RET)
Protein kinases [BR:
uah01001
]
Receptor tyrosine kinases (RTK)
RET family
113243095 (RET)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
RET_CLD1
RET_CLD4
RET_CLD3
Pkinase
Cadherin
RIO1
Pkinase_fungal
Haspin_kinase
Motif
Other DBs
NCBI-GeneID:
113243095
NCBI-ProteinID:
XP_057164758
EnsemblRapid:
ENSUARG00005007693
LinkDB
All DBs
Position
Unknown
AA seq
1117 aa
AA seq
DB search
MAKATATAGAAGLRLLLLLPLLGEAPLGLYFSRDAYWEKLYVDQPAGMPLLYVHALRDVP
EEVPSFRLGQHLYGIAYRARLHENDWIRIEEDTGLLYLNRSLDHSAWEKLSIRNGGFPVL
TIYLQVFLSSASLREGECQWPGCARVYFSFINTSFPACSSLKPRELCFPETGVSFRIREN
RPPGTFHQFRLLPVQFLCPNISVSYRLLEGENLPFRCAPDSLEVSTRWALDRELREKYEL
VAACTVRVGARKEEVVMVPFPVTVYDEDDSAPTFLGGFDTASAVVEFKRKEGTVVATIRV
FDADVVPASGELLRRYTSTLLPGEAWALQTFRVEHSPNETLVQANGSFVRATVHDYRLVL
NRSLPISESRSLQLAVLVNDSDFQGPGEGVLLLHFNVTVLPVSLHLPSAYSFTVSKRARR
FAQIGKVCVDNCQEFSGIHVQYKLQLSSTNCSVLGVVTSAEDTTGTLFVNDTEALQRLDC
SQLQYTVVAADRPTRRQTQAPLVVTVEGTYVAEEPGCPLSCAVSKRRPECEECGGLGSLT
GRCEWRQGDGKGITRNFSTCSPSIKTCPDGHCDAVESRNVNICPQDCLRGGSIIGGHEPG
DRWGIKAGFGICNCFPEEKKCFCEPEDSLDPLCDELCRTVIAAAVLFSFIISMLLSTFCI
HRYHKNAHKPPIASAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKIPEDPKW
EFPRKNLVLGKTLGEGEFGKVVKATAFRLKGKAGYTTVAVKMLKENASPSELRDLLSEFN
LLKQVNHPHVIKLYGACSQDGPLFLIVEYAKYGSLRGFLRESRKAGPGYVGSGGSRSSSY
LDNPEERALTMGDLISFAWQISRGMRYLAEMKLVHRDLAARNVLVAEGRKMKISDFGLSR
DVYEEDSYVKRSKGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPP
ERLFNLLKTGYRMERPDNCSEEMYGLMLQCWKQEPDKRPVFADISKDLEKMMVKNRDYLD
LAASTPSDSLLYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPEESPVPL
TRADGTNTVCPRYANDRVYANWMVSPSAAQLTDAFDS
NT seq
3354 nt
NT seq
+upstream
nt +downstream
nt
atggcgaaggcgacggcgacggccggcgccgcggggctgcggttgctgctgctgctgccg
ctgctcggcgaagctccactgggactctacttctccagggatgcttactgggagaaactg
tacgtggaccagccggctggcatgcccctgctctacgtccatgctctgcgggacgtcccc
gaggaggtgcccagcttccgcctgggccagcatctctacggcatcgcctaccgcgcaagg
ctgcatgagaacgactggatccgcatcgaggaggacacaggccttctctaccttaaccgg
agcctggatcacagcgcctgggagaagctcagcatccgcaatggcggcttccctgtgctc
accatctacctccaggtcttcctgtcgtctgcgtccctgcgtgagggcgagtgccagtgg
ccaggctgtgcccgtgtgtacttctcctttatcaacacctccttcccagcttgcagttct
ctcaaaccccgggagctctgctttcctgagacaggtgtctccttccgcatcagagagaac
aggcctcctggcaccttccaccaattccggctgctgcctgtgcagtttctctgccccaac
atcagtgtgtcctacaggctcctagaaggtgagaatctgcccttccgttgcgccccggac
agcctggaggtgagcacacgctgggccttggaccgcgagctgcgggagaagtatgagctg
gtggccgcgtgcacggtgcgcgtcggcgcgcgcaaggaggaggtggtgatggtgcccttc
cctgtgaccgtgtacgatgaggacgactcggcgcccaccttcctcgggggcttcgacacc
gccagcgctgtggtggagttcaagaggaaggagggcactgtggtggccacaatacgtgtc
ttcgacgcagatgtggtgccagcatctggggagctcctgaggagatacacaagcacacta
ctccctggggaggcctgggccctccagacattccgtgtcgagcactcacccaacgagacc
ttggtccaggccaatggcagctttgtgcgggcaactgtgcacgactacaggctggttctc
aaccggagcctccccatctcggagagccgctccctgcagctggccgtgctggtcaatgac
tcggacttccagggccccggggagggtgtcctcctcctccacttcaacgtgaccgtgctg
cctgtcagcctgcacttacccagcgcctactccttcactgtgagcaagcgggcccgccgc
tttgcccagattgggaaagtctgtgtggacaactgccaggagttcagcggcatccacgtg
cagtacaagctgcagctctccagcaccaactgcagtgtcctgggggtggtcacctcagcc
gaggacaccacggggaccctgttcgtgaatgacacggaagccctgcagcggctcgattgt
tctcaactccagtacacggtggtggctgccgaccggccaacccgcaggcagacccaggcc
ccgctggtcgtcaccgtggaggggacgtatgtggctgaggagccaggctgccctctgtcc
tgtgcagtcagcaagaggcggcctgagtgtgaggagtgcggcggcctgggctctctgacg
ggcaggtgcgagtggagacagggagatggcaaagggatcacgaggaacttctccacctgc
tcccccagcatcaagacctgccccgatggccactgtgatgctgtggagagcagaaatgtc
aacatctgcccccaggactgcctcaggggcggcagcatcattggtgggcacgagccaggg
gaccgctggggaataaaagctggcttcggtatctgcaactgtttccctgaagagaagaag
tgcttctgtgagcctgaagacagcctggacccactgtgtgacgagctctgccgcacagtg
atcgcggcggccgtgctcttctccttcatcatctccatgctgctctccaccttctgcatc
caccgctaccacaagaacgcccacaagccgcccatcgcctccgccgagatgaccttccgc
cggccggcccaggccttcccagtcagttactcctcgtcgggtgcccgccggccctccctg
gactccatggagaaccaggtctctgtggatgccttcaagatcccggaggatccaaagtgg
gaattccctcggaagaacttggttcttggaaaaactctgggagaaggtgaatttggaaaa
gtggttaaggcaaccgccttccggcttaaaggcaaagcagggtacacaaccgtggccgtg
aagatgctgaaagagaacgcctccccaagcgagctgcgggacctgctgtcagagttcaac
ctcctgaagcaggtcaaccacccacatgtcatcaagctgtacggggcctgcagccaggat
gggccactcttcctcattgtggagtacgccaagtacggctccctgcggggattcctccga
gagagccgcaaggccgggccgggctacgtgggcagtggaggcagccgcagctccagctac
ctggacaaccccgaggagcgggccctgaccatgggtgacctcatctccttcgcctggcag
atctctcgggggatgcggtacctggcggagatgaagcttgtccatcgggacttggctgcc
agaaatgtcctggtagccgaggggcggaagatgaagatttcagattttggcctatcccga
gatgtttatgaagaggattcctatgtgaagaggagcaagggtcggattccagtcaaatgg
atggcaattgagtctcttttcgatcatatctacaccacccagagtgatgtgtggtccttc
ggtgtcctgctgtgggagattgtgactctggggggcaacccctacccggggattcctcca
gagcggctcttcaaccttctgaagacaggctaccggatggagaggcctgacaactgcagc
gaggagatgtatggtctaatgctgcaatgttggaagcaggaaccagacaagaggccggtg
tttgctgacatcagcaaagacctggagaagatgatggttaagaacagagactacttggac
ttggccgcgtccaccccatctgactccctgctttacgacgatggcctctcagaggaggag
acgcccctggtggactgtaataatgctcccctccctcgagcccttccctccacgtggatt
gaaaacaaactctatggcatgtcagacccgaactggcctgaagagagtcctgtaccactc
acgagagctgatggcactaacactgtgtgtccacgatatgcaaatgatagggtatatgct
aactggatggtttcaccctcagcggcacaattaacggacgcgtttgatagttaa
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