Ursus arctos horribilis (North American brown bear): 113243183
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Entry
113243183 CDS
T05909
Symbol
PLCE1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1
KO
K05860
phosphatidylinositol phospholipase C, epsilon [EC:
3.1.4.11
]
Organism
uah
Ursus arctos horribilis (North American brown bear)
Pathway
uah00562
Inositol phosphate metabolism
uah01100
Metabolic pathways
uah04014
Ras signaling pathway
uah04015
Rap1 signaling pathway
uah04020
Calcium signaling pathway
uah04024
cAMP signaling pathway
uah04070
Phosphatidylinositol signaling system
uah04919
Thyroid hormone signaling pathway
uah04933
AGE-RAGE signaling pathway in diabetic complications
uah05205
Proteoglycans in cancer
Module
uah_M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:
uah00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
113243183 (PLCE1)
09130 Environmental Information Processing
09132 Signal transduction
04014 Ras signaling pathway
113243183 (PLCE1)
04015 Rap1 signaling pathway
113243183 (PLCE1)
04020 Calcium signaling pathway
113243183 (PLCE1)
04070 Phosphatidylinositol signaling system
113243183 (PLCE1)
04024 cAMP signaling pathway
113243183 (PLCE1)
09150 Organismal Systems
09152 Endocrine system
04919 Thyroid hormone signaling pathway
113243183 (PLCE1)
09160 Human Diseases
09161 Cancer: overview
05205 Proteoglycans in cancer
113243183 (PLCE1)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
113243183 (PLCE1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
uah04131
]
113243183 (PLCE1)
Enzymes [BR:
uah01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
113243183 (PLCE1)
Membrane trafficking [BR:
uah04131
]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
113243183 (PLCE1)
Endocytosis
Macropinocytosis
Phospholipase C
113243183 (PLCE1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PI-PLC-X
PI-PLC-Y
RasGEF
RA
C2
EF-hand_like
GDPD
Motif
Other DBs
NCBI-GeneID:
113243183
NCBI-ProteinID:
XP_026337473
LinkDB
All DBs
Position
Unknown
AA seq
2301 aa
AA seq
DB search
MTSEEMAASVLTPVTQRRVTSTPSAVDESSEKVLDVIVPKAHSVRQSGQTSTIPQMNKLK
EEPSGSNLPKILSIAREKIVSNENSNEKCWAESTPVSVKNLNISHNNILTNHQCVLPQSQ
CYDTCDSVMEEDPCLETGIPSSLERKAFPGIQLEIDGPPMDISPLGSQLAIVETGPAHPD
GNTAAFCFHYGADRTVSDAFCTLSGNLILDDCGNCVPLPGVGGEQKKNYVAYTCKLMELA
ENCDNKNGQLQCDHCDTLDDKYLCLEGSCQRASVVCSSDSFCREDLTNSPPAKTFLSHFE
DFPDNCEDAEEDFFKSKKERSTLLVRRFCKNDREVKKSVYTGTRAIVRTLPSGHIGLGAY
SYIDQKRSGPLLPCGRVLERLSVVAIRQDGSQCLSEAQWYQIYNAVRRGEEIENTIGSLL
HVFTKLPASETTHERISVGPCLKQCVRDTICEYRATLQRTSISQYITGSLLEATTSLGAR
SGLLSTFGGSTGRMMLKERQPGTSMANSSALPSSSAGISKELIDLQPLIQFPEEVASILM
EQEQNIYRRVLPVDYLCFLTRDLGTPECQTSLPCLKASISASILTSQNGEHNALEDLVMR
FNEVSSWVTWLILTAGSMEEKREVFSYLVHVAKCCWNMGNYNAVMEFLAGLRSRKVLKMW
QFMDQSDLETMRSLKDAMAQHESSCEYRKVITRALHIPGCKVVPFCGVFLKELCEVLDGA
SGLMKLCPRYNSQEETLEFVADYSGQDNFLQRVGHNGLKNSEKESTVNSIFQIIRSCSRS
LEAEDEDSPSEGNSSRKNSLRDKARWQFIIGDLLDSENDLCEQSKEWDSHGSEEPQKAFD
HGTELIPWYVLSIRADVHQFLLQGATVIHYDQDTHLSARCFLQLQPDNSTLTWVKPTTAS
PASAKAKLGVLSNTAEPGKFPLLGNAGLSGLAEGVLDLFSAKAVYMGHPSIDIHTVCVQN
KLGSMFLSETGVTLLYGLQTTDNRLLHFVAPKHTAKMLFSGLLELTRAVRKMRKFPDQRQ
QWLRKQYVSLYQEDGRYEGPTLAHAVELFGGRRWSTRNPSPGTSAKSTEKPSVQRNNTLG
ISTTKKKKKILIRGESGEAADDEMATRKAKMHRESRSRSGSDPQDMNEQEESEANAIMSP
PNTLPSRRAHSLTTAGSPNLSAGTSSPIRPVSSPVLSSSNKSPSSPWSSSSWHGRIKGGM
KGFQSFMVSDSNMSFVEFVELFKSFSVRSRKDLKDLFDIYAVPCNRAGSESAPLYTNLTI
DENTSDLQPDLDLLTRNVSDLGLFIKSKQQLSDNQRQISDAIAAASIVTNGTGVESTSLG
IFGVGILQLNDFLVNCQGEHCTYDEILSIIQKFEPSVSMCHQGLLSFEGFARFLMDKDNF
ASKNDESQENIKDLQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSVELDC
WDGDDGMPIIYHGHTLTTKIPFKEVVEAIDRSAFINSDLPIIISIENHCSLPQQRKMAEI
FKTVFGEKLVAKFLFESDFSDDPMLPSPDQLRRKVLLKNKKLKAHQTPVDILKQKAHQLA
SMQAQAYNGGNANPPPANNEEEEDEEDEYDYDYESLSDDNILEDRPENKSCNDKLQFEYN
EEIPKRIKKADNSACNKGKVYDMELGEEFYLPQNKKESRQIAPELSDLVIYCQAVKFPGL
STLNASGSSRGKERKSRKSIFGNNPGRMSPGETASFNKASGKSSCEGMRQAWEESSSPLN
PTTSLSAIIRTPKCYHISSLNENAAKRLCRRYSQKLIQHTACQLLRTYPAATRIDSSNPN
PLMFWLHGIQLVALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKNCPMYQKFSPLE
RDLDNMEPAVYSLTIVSGQNVCPSSSTGSPCIEVDVLGMPLDSCHFRTKPIHRNTLNPMW
NEQFLFRVHFEDLIFLRFAVVENNSSAVTAQRTIPLKALKRGYRHLQLRNLHNEVLEISS
LFINSRRMEENSSSSAVPASLMFNTEERKCLQTHRVTVHGVPGPEPFTVFSINGGTKAKQ
LLQQILTTEQDTKPIVTDYFLMEEKYFISKEKNECRKQPFQRVIGPEEEIMQILSSWFPE
EGYVGRIVLKTQQENLEERSIVQDDKEVILSSEEESFFVQVHDVSPEQPRTVIKAPRVST
AQDVIQQTLCKAKYSYSILSNPNPSDYVLLEEVVKDATKKSSTPKSSQRVLLDQECVFQA
QSKWKGAGKFILKLKEQVQASREDKRKGISFASEFKKFTKSTKQPRGLTSPSQVLASEGV
QSKEEKPVGSLPSSDTTDYRQ
NT seq
6906 nt
NT seq
+upstream
nt +downstream
nt
atgacgtctgaagaaatggcagcttctgttctcacacctgtgactcagagaagagtgacg
tccactccatcagctgtagatgaaagtagtgaaaaggtgttggacgtcattgttcctaaa
gcacatagtgtcaggcagagcgggcagacttctaccatcccacagatgaacaagcttaaa
gaagaaccttctggaagcaacttgcccaagattctctccatagcaagggagaaaatagtg
agcaatgagaacagcaatgaaaagtgctgggcagaaagtacaccagtttctgtgaaaaac
cttaacattagccacaacaacatactgacaaaccaccagtgtgtccttcctcagagccag
tgttatgacacgtgtgattctgtcatggaggaagacccatgtttggaaactggaatcccg
tcctcactggaaagaaaggcattccctggaattcaactggaaatcgacggacctcccatg
gacattagtcccttaggaagtcagttggccattgtagagactggcccggcacaccctgat
ggcaacacagcagcattttgctttcattatggagctgacagaacagtgtcagatgctttc
tgtaccctgtcaggcaacttgattttggatgattgtggaaactgtgtaccactacctggt
gttggtggggaacaaaagaaaaattatgtggcgtatacttgtaaactcatggaattggcc
gaaaactgtgataataagaatgggcagctgcagtgtgatcattgtgacaccttggatgac
aaatacttgtgcttggaaggttcttgccaaagggccagtgtggtatgttcaagtgacagc
ttttgcagggaggacttgactaacagtccacctgccaagacctttctgagccattttgag
gacttccctgacaattgtgaagatgcagaggaagatttttttaaaagcaaaaaggagagg
tccactttgttagtgaggagattttgcaaaaatgacagggaagtaaagaaatctgtgtat
actgggacaagggcaatcgtgaggactctgccttctggtcacattgggctgggagcttac
agttacatcgatcagaagagaagtggtcccttgttgccctgtggaagagttctggaacgg
ctgtcagtggtggcgattaggcaggatgggagccagtgcctatcagaagcccagtggtat
cagatctacaatgcagtgcgaaggggagaagaaatagaaaatacaattggatctcttctc
catgtcttcacaaagctcccagcctctgagacaacccatgaaaggattagcgttggtcca
tgcttaaagcagtgtgtccgagacaccatatgtgagtaccgtgccaccctgcaaaggaca
tccatatctcagtacatcacgggttctctcctagaagcaaccacgtctttgggagcaaga
agtggcctactcagtacttttggaggctctactggacgaatgatgctaaaagaacgccaa
ccaggcacctccatggccaattccagtgccctcccttcaagttcagctgggatcagcaag
gagctgattgacctgcagcccctcattcagttcccagaggaagtcgccagcattctgatg
gagcaggaacagaacatttaccgaagggtcttgccagttgactacctttgcttcttgacc
cgggacttgggcactccggaatgccagacgtccctgccctgcctcaaagcatccatctca
gcttcaattcttacctcccagaatggagagcacaatgccctggaagatctggtgatgaga
tttaatgaggtgagctcctgggtgacgtggttgatcctcacggcgggctccatggaggag
aagcgagaagtcttctcctatttggtgcacgtggccaaatgctgctggaacatgggcaac
tacaatgctgtcatggagttcttggctggcctcaggtcaagaaaagttttgaaaatgtgg
cagtttatggaccagtctgacctggagaccatgaggagcctgaaggacgccatggctcag
cacgaatcttcctgcgagtacaggaaggtgatcacgcgggccctgcacatacccggctgt
aaggtggtcccgttctgtggggtgtttctgaaggagctctgtgaagtactggacggagcc
tctggcctcatgaagctttgcccgaggtacaattctcaagaagaaactctagagtttgta
gccgactacagtggacaagataatttcttacaacgagtgggacataatggcctgaagaat
tcagagaaggagtccaccgtcaacagcatctttcagatcatcaggagctgcagccgaagt
ctggaggccgaggacgaggacagccccagtgagggcaacagctctaggaaaaattcctta
agggataaagcgcggtggcagtttataattggagatttgctggattccgaaaatgacctc
tgtgagcagtcgaaagaatgggactctcatggatcagaagagccacagaaggcctttgac
cacgggacagagctgatcccgtggtacgtgctgtccatccgagctgatgtgcaccagttc
ctgctgcagggggccactgtcatccactacgaccaggacacgcacctgtcggcccgctgc
ttcctccagctccagcctgacaacagcactttgacctgggtaaagcccaccactgcctcc
ccagccagtgctaaagcaaaacttggtgtgcttagtaacacggctgagcctggcaaattc
ccgttactgggcaatgctggattaagtggcctggcggagggggtcttggatctgttttca
gcaaaggctgtgtacatgggacaccctagcatcgatatacacactgtgtgtgttcagaac
aaactgggtagcatgtttctctcagagactggcgtgacactgctctatgggctgcagacc
acggacaataggttattgcactttgtggcgcccaagcacaccgctaagatgctcttcagt
ggattgctagaactcacgagggccgtgaggaagatgaggaagttccctgaccagagacag
cagtggctgcggaaacagtatgtcagcctctatcaggaggatggacggtacgaaggccca
actttggctcacgccgtggagctgtttggtggccggcgatggagtacacgcaaccccagc
cctgggacatccgcgaagagtactgagaagcccagtgtgcagagaaacaacacgttgggc
ataagcaccaccaagaaaaagaagaaaatccttataaggggtgagagtggagaggcggcc
gacgacgagatggccacgcggaaggccaaaatgcacagggagagtcgcagccggagtggt
tccgaccctcaagacatgaatgagcaagaagaatctgaggcgaatgccatcatgagccct
cctaacactctgccttccagaagagcccactctttgaccacggctgggtcccctaacttg
tctgctgggacatcatctcccatcaggccagtgtcctcccctgtgctgtcttcttcaaac
aagagcccgtccagtccttggagcagcagcagctggcacgggaggatcaaaggaggaatg
aagggttttcagagcttcatggtttcagacagtaacatgagttttgttgaatttgttgag
ctgttcaaatcattcagcgtgaggagccgcaaggacctgaaggatctctttgacatctat
gccgtgccctgcaaccgagccggctcggagtcagcccccctctacaccaacctaaccatt
gacgaaaataccagcgaccttcagcctgacctagatttattgaccagaaatgtctcagac
ttgggattgttcattaagagtaaacagcagctgtcagacaaccagaggcagatatctgat
gccattgctgctgcaagtatcgtgacaaatggcactggggtcgagagcacatctctgggc
atctttggggttggcatactccagctcaatgacttcctcgtcaactgccagggagaacac
tgcacttacgatgaaatcctcagcatcatccagaagttcgagcctagcgttagtatgtgt
catcagggcctactgtcatttgagggatttgcaaggtttctgatggataaagataatttt
gcctccaaaaatgacgagtcacaggagaacattaaagacttgcagctgcccctctcctat
tattacattgaatcttcacacaatacctacctcacagggcaccagctcaaaggagagtcc
tcagtggaactctacagccaggtcctcctgcaaggctgcagaagcgtagagttggactgc
tgggacggagatgatgggatgcccattatctaccacggacacacactgacaaccaagatc
cccttcaaggaggtggttgaagccattgaccgcagtgccttcatcaactctgacctgccc
atcatcatatcaattgagaaccactgctcattgcctcagcaacgaaaaatggcagaaatt
ttcaagactgtgtttggagaaaaactggtggctaaattcctgtttgagagcgatttctca
gatgatccaatgcttccctcacctgaccaacttaggaggaaagtgcttcttaaaaataag
aagctcaaagcccaccagacaccagtggatatcttaaagcaaaaggctcatcagttagca
tccatgcaagctcaggcttataatggggggaatgccaaccccccacctgctaataacgag
gaagaggaggatgaagaagacgaatatgattatgactatgaatccctgtctgatgacaat
attctagaagacagacctgaaaataaatcatgtaatgacaagcttcagttcgagtataat
gaagaaatccccaagaggataaagaaagccgacaactctgcttgcaacaaaggaaaggtt
tatgacatggaactgggagaagaattttatcttcctcagaataaaaaggaaagtagacag
attgcaccagagctttctgaccttgtcatctattgccaagcagtaaaatttccaggcctg
tcaactctaaatgcatctggctctagcagaggaaaagaaaggaaaagcaggaagtccatt
tttggcaacaatccgggcagaatgagccctggggagacagcatcgtttaacaaagcatct
ggaaaaagttcctgtgaaggaatgcgacaggcctgggaggagtcttcttcccccctcaac
ccaaccacatccctcagcgctatcattagaactcccaaatgttaccatatctcatcgctg
aatgaaaatgccgccaaacgtctgtgtcgcaggtattctcagaaactgatccagcacacc
gcctgtcagctgctgaggacttacccggctgccacccgcatcgactcctccaaccccaat
cccctcatgttctggctccatgggatacagcttgtggcgctcaactaccagacagatgat
ctccccttacatttaaatgctgccatgtttgaggccaacggtggctgtggttacgttctg
aaacccccagttctgtgggacaagaactgtcccatgtatcagaagttttcacccttggaa
agagacctggacaacatggagcctgccgtctattccttaactattgtctctggtcaaaac
gtgtgtccgagcagcagcacggggagcccgtgtatcgaagtcgacgtgctgggcatgccc
ttggacagctgccacttccgcacgaagcccatccaccggaacactctgaaccccatgtgg
aatgaacagtttctcttccgggtgcactttgaagacctcatatttcttcgttttgcagtt
gtggaaaacaacagctcagccgtaaccgctcagagaaccatcccgctcaaggctttgaaa
cgaggatatcggcatcttcagctacgaaacctccacaatgaagtcttagaaatctccagt
ttattcataaacagcagaaggatggaagaaaattcctccagcagtgccgtgccggcctct
ttgatgtttaatacagaagaaagaaaatgtttgcagactcacagagttacagtgcatggg
gtcccaggtccagagccatttactgttttctccataaacgggggcaccaaggcaaagcag
cttctccaacaaattctgactactgaacaggacaccaaacctattgtcacagactatttt
ttgatggaagaaaaatattttatatctaaagaaaagaatgaatgcaggaaacaaccattc
cagagagtcatcggtccagaagaagagatcatgcagattttaagcagctggtttccagag
gaaggatatgttggcaggattgtcttaaaaacccagcaggaaaacctagaagagagaagc
attgttcaagatgacaaagaggtgatcttgagctcagaggaggagagtttctttgtccaa
gtgcacgacgtttctccagagcaacctcgaacagtcatcaaagcgccccgtgtcagcacc
gcgcaggacgtcattcagcagaccttatgcaaagccaaatattcctatagcatcctgagc
aaccccaacccgagtgactatgtgcttctggaggaggtggtgaaagacgctaccaagaag
tcttccaccccaaagtcctcccagcgggtccttttggatcaggagtgtgtgtttcaagcc
cagagcaagtggaagggtgcaggaaaattcatccttaagctaaaggagcaggtacaggca
tcccgagaagacaaaagaaaaggcatttcttttgcaagtgaattcaagaagttcactaaa
tcaactaaacagccccgaggactcacgtcaccttctcaggtcttagcctcagaaggtgtc
caaagcaaggaggagaaaccagtgggcagcttgccttccagtgacaccacagactaccga
caataa
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integrated database retrieval system
