Ursus americanus (American black bear): 123799951 Help Entry 123799951         CDS       T07931                                  Symbol ADCY3 Name (RefSeq) adenylate cyclase type 3   KO K08043   adenylate cyclase 3 [EC:4.6.1.1] Organism uar  Ursus americanus (American black bear) Pathway uar00230   Purine metabolism uar01100   Metabolic pathways uar01522   Endocrine resistance uar04015   Rap1 signaling pathway uar04020   Calcium signaling pathway uar04022   cGMP-PKG signaling pathway uar04024   cAMP signaling pathway uar04062   Chemokine signaling pathway uar04072   Phospholipase D signaling pathway uar04114   Oocyte meiosis uar04211   Longevity regulating pathway uar04213   Longevity regulating pathway - multiple species uar04261   Adrenergic signaling in cardiomyocytes uar04270   Vascular smooth muscle contraction uar04371   Apelin signaling pathway uar04540   Gap junction uar04611   Platelet activation uar04713   Circadian entrainment uar04714   Thermogenesis uar04723   Retrograde endocannabinoid signaling uar04724   Glutamatergic synapse uar04725   Cholinergic synapse uar04727   GABAergic synapse uar04740   Olfactory transduction uar04750   Inflammatory mediator regulation of TRP channels uar04911   Insulin secretion uar04912   GnRH signaling pathway uar04913   Ovarian steroidogenesis uar04914   Progesterone-mediated oocyte maturation uar04915   Estrogen signaling pathway uar04916   Melanogenesis uar04918   Thyroid hormone synthesis uar04921   Oxytocin signaling pathway uar04923   Regulation of lipolysis in adipocytes uar04925   Aldosterone synthesis and secretion uar04926   Relaxin signaling pathway uar04927   Cortisol synthesis and secretion uar04928   Parathyroid hormone synthesis, secretion and action uar04934   Cushing syndrome uar04935   Growth hormone synthesis, secretion and action uar04962   Vasopressin-regulated water reabsorption uar04970   Salivary secretion uar04971   Gastric acid secretion uar04972   Pancreatic secretion uar04976   Bile secretion uar05032   Morphine addiction uar05163   Human cytomegalovirus infection uar05166   Human T-cell leukemia virus 1 infection uar05200   Pathways in cancer uar05207   Chemical carcinogenesis - receptor activation uar05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:uar00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     123799951 (ADCY3)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     123799951 (ADCY3)    04371 Apelin signaling pathway     123799951 (ADCY3)    04020 Calcium signaling pathway     123799951 (ADCY3)    04072 Phospholipase D signaling pathway     123799951 (ADCY3)    04024 cAMP signaling pathway     123799951 (ADCY3)    04022 cGMP-PKG signaling pathway     123799951 (ADCY3)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     123799951 (ADCY3)   09144 Cellular community - eukaryotes    04540 Gap junction     123799951 (ADCY3)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     123799951 (ADCY3)    04062 Chemokine signaling pathway     123799951 (ADCY3)   09152 Endocrine system    04911 Insulin secretion     123799951 (ADCY3)    04923 Regulation of lipolysis in adipocytes     123799951 (ADCY3)    04912 GnRH signaling pathway     123799951 (ADCY3)    04913 Ovarian steroidogenesis     123799951 (ADCY3)    04915 Estrogen signaling pathway     123799951 (ADCY3)    04914 Progesterone-mediated oocyte maturation     123799951 (ADCY3)    04921 Oxytocin signaling pathway     123799951 (ADCY3)    04926 Relaxin signaling pathway     123799951 (ADCY3)    04935 Growth hormone synthesis, secretion and action     123799951 (ADCY3)    04918 Thyroid hormone synthesis     123799951 (ADCY3)    04928 Parathyroid hormone synthesis, secretion and action     123799951 (ADCY3)    04916 Melanogenesis     123799951 (ADCY3)    04925 Aldosterone synthesis and secretion     123799951 (ADCY3)    04927 Cortisol synthesis and secretion     123799951 (ADCY3)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     123799951 (ADCY3)    04270 Vascular smooth muscle contraction     123799951 (ADCY3)   09154 Digestive system    04970 Salivary secretion     123799951 (ADCY3)    04971 Gastric acid secretion     123799951 (ADCY3)    04972 Pancreatic secretion     123799951 (ADCY3)    04976 Bile secretion     123799951 (ADCY3)   09155 Excretory system    04962 Vasopressin-regulated water reabsorption     123799951 (ADCY3)   09156 Nervous system    04724 Glutamatergic synapse     123799951 (ADCY3)    04727 GABAergic synapse     123799951 (ADCY3)    04725 Cholinergic synapse     123799951 (ADCY3)    04723 Retrograde endocannabinoid signaling     123799951 (ADCY3)   09157 Sensory system    04740 Olfactory transduction     123799951 (ADCY3)    04750 Inflammatory mediator regulation of TRP channels     123799951 (ADCY3)   09149 Aging    04211 Longevity regulating pathway     123799951 (ADCY3)    04213 Longevity regulating pathway - multiple species     123799951 (ADCY3)   09159 Environmental adaptation    04713 Circadian entrainment     123799951 (ADCY3)    04714 Thermogenesis     123799951 (ADCY3)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     123799951 (ADCY3)    05207 Chemical carcinogenesis - receptor activation     123799951 (ADCY3)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     123799951 (ADCY3)    05163 Human cytomegalovirus infection     123799951 (ADCY3)   09165 Substance dependence    05032 Morphine addiction     123799951 (ADCY3)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     123799951 (ADCY3)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     123799951 (ADCY3)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     123799951 (ADCY3) Enzymes [BR:uar01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      123799951 (ADCY3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc AC_N HNOBA DUF3810 Motif Other DBs NCBI-GeneID:  123799951 NCBI-ProteinID:  XP_045665250 LinkDB All DBs Position Unknown AA seq 1145 aa AA seqDB search MPRNQGFSEPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPE SLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCTVVFSSDKLAPLLVAGMGLLLDIL LFVLCKKGLLPDRVTRKVVPYLLWLLITAQIFSYLGLNFARAHSASDTVGWQAFFVFSFF ITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQDGLKGMHLLREILANVSLYLCAVTVG VMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDES QKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQ LRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTV LGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTLDCLKGEFDVEPGDGGSRCE YLDEKGIETYLIIASKPEVKKTAAQHGLGGPALLNGAPASSKPSSPALIETKEPNGSIHT GGSTSEEPEEQETQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESA QVVKKRNTFLLSMRFMDPDMETRYSVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTN YMTFVVGEVLLLILTICSLAAIFPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMAN VVDMLSCLQYYTGPTNSTAGLEVEDGCVENPKYYNYVAVLSLIATIMLVQVSHMVKLTLM LLVTGAVAVINIYAWRPIFDEYDRKRFQEHDFPAVALEKMQGFSTPGLNGTGRLPLVPSK YSMTAMILVMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEH VARHFLGSKKRDEELYSQSYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDF DSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFASSNKEEKSDKERWQHLADLADF ALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGV MGNIQVVEETQAILREYGFRFVRRGTIFVKGKGELLTFFLKGRDKPAAFPNGSSVTLPHQ VVDNS NT seq 3438 nt NT seq  +upstreamnt  +downstreamnt atgccgaggaaccagggcttctccgagcctgagtactcggccgagtactccgccgagtac tcggtcagcctgccctctgaccctgaccgcggggtgggccggacccatgaaatctcggtc cggaactcgggatcctgcctctgcctgcctcggttcatgcggctgaccttcgtgcccgag tccttggagaacctgtaccagacctacttcaaacggcagcgccatgagaccctgctggtg ctggtggtgttcgcggcgctcttcgactgctatgtggtggtcatgtgcacggtggtcttc tccagcgacaagctggctcccctcctcgtggctgggatgggactgctgttggacatcctc ctcttcgtactctgcaaaaaggggctgctcccggaccgggtcacccggaaagtggtgccc tacctgctgtggctactgataactgcccagattttctcttacctgggcctgaactttgcc cgagcccactcggccagtgacacggtgggctggcaggccttctttgtcttctccttcttc atcacgctgccgctcagcctcagccccatcgtcatcatctctgtggtctcctgcgtcgtg cacacactcgtcttgggggtcaccgtggcccagcagcagcaggacgggctgaagggcatg cacttgctgagggagatcctggcgaacgtctccctctacctgtgcgccgtcaccgtgggc gtcatgtcctactacatggcggaccgcaagcaccgcaaggccttcctggaggcccgccag tcgctggaggtgaagatgaacctggaggagcagagccagcagcaggagaaccttatgctc tccatcctgcccaagcacgtggctgacgagatgctgaaggacatgaagaaggacgagagc cagaaggaccagcagcagttcaacaccatgtacatgtaccggcacgagaacgtcagcatc ctctttgcggacattgtgggcttcacccagctgtcttctgcctgcagtgcccaggagctc gtgaagctgctcaacgagctctttgcccgcttcgacaagctggcagccaaataccaccag ctgcggattaagatcctaggcgactgttactactgcatctgcggcctgcccgactaccgg gaggaccacgccgtctgctccatcctcatggggctcgccatggtggaggccatctcgtac gtgcgggagaagacgaagactggggtggacatgcgcgtgggggtgcacacgggcaccgtg ctggggggcgtcctgggccagaaacgctggcagtacgacgtgtggtctaccgacgtcact gtggccaacaagatggaggcgggaggcatccccgggcgtgtgcacatctcccagagcacc ctggactgcctgaagggcgagttcgatgtggagccgggcgacgggggcagccgctgtgag tacctggacgagaagggcatcgagacctacctcatcatcgcgtccaagccagaggtgaag aagacagccgcccagcacggcctcggtggcccggccctgctgaacggagccccggcttcc tccaagcccagctcgcccgccctcatcgagaccaaggagcccaacgggagcatccacacc ggcggctccacgtcggaggagcccgaggagcaggagacccaggccgacaacccctcgttc cccaacccgcgccggaggctgcgccttcaggacctggctgaccgagtggtggacgcctcc gaggacgagcacgagctcaaccagctactcaacgaggccctgctggagcgagagtccgcc caggtggtgaagaagagaaacaccttcctcctttccatgcggttcatggaccccgacatg gaaacccgctactcagtggagaaggaaaagcagagcggggctgccttcagctgctcctgc gtcgtcctgctctgtacggccctggtcgagatactcatcgacccctggctaatgacaaac tacatgacctttgtggttggggaggttctgcttctgatcctgacaatctgctcgctggcc gccatctttccccgggcctttcctaagaagctcgtggccttctccacttggatcgaccgg acccgctgggccaggaacacctgggccatgttagccatctttattctggttatggcaaat gtcgtggacatgctcagctgtctccagtactacacaggcccaaccaacagcactgcaggg ctggaggtggaagacggctgcgtcgagaaccccaagtattacaactatgtcgccgtgctg tccctcatcgccaccatcatgctggtgcaggtcagccacatggtgaagctcacactcatg ctgctcgtcaccggggctgtggccgtcatcaacatctatgcctggcgccccatctttgat gaatacgaccgcaaacgttttcaggaacatgacttccctgcagtcgccttagagaagatg cagggattttccacccctgggctcaatggcaccggcaggctgcccctggtaccttctaag tactccatgaccgcgatgatcctcgtcatgatgctgagcttctactacttctcacgccac gtggaaaaattggcaaggacactgttcttgtggaagattgaggtccacgaccagaaggaa cgggtctacgagatgcggcgctggaatgaggccttggtcaccaacatgttgcctgagcac gtggcacgccatttcctggggtccaagaagagagatgaggagctgtacagccagtcttac gatgagatcggagtcatgtttgcctccctgcccaacttcgccgacttctacacggaggag agcatcaacaacggcggcattgagtgtctgcgcttcctcaacgagatcatctccgacttt gattctctcctggacaatcccaagttccgggtcatcaccaagatcaaaaccattggcagc acctacatggccgcttccggagtcaccccggatgtcaacaccaacggctttgccagctcc aacaaggaggagaagtcagacaaggagcgctggcagcacctggctgatctggccgacttc gctctggccatgaaggatacgctcacaaacatcaacaaccagtccttcaacaacttcatg ctgcgcatcggcatgaacaaaggaggggtcctggctggggtcattggagcccggaaacca cactatgacatctggggcaacacagtcaatgtggccagcaggatggagtccacaggggtc atgggcaacattcaggtggtggaagaaacacaagccatccttcgagagtacggcttccgc tttgtgaggcgagggacaatctttgtgaaagggaaaggggagctgctaacctttttcttg aaggggcgtgataagccagctgccttcccaaatggctcctcggtcaccctgccccaccag gtggtagacaactcctga

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