KEGG   Ursus maritimus (polar bear): 103662093
Entry
103662093         CDS       T03271                                 
Symbol
PLCG2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1
  KO
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
umr  Ursus maritimus (polar bear)
Pathway
umr00562  Inositol phosphate metabolism
umr01100  Metabolic pathways
umr01521  EGFR tyrosine kinase inhibitor resistance
umr04012  ErbB signaling pathway
umr04014  Ras signaling pathway
umr04020  Calcium signaling pathway
umr04062  Chemokine signaling pathway
umr04064  NF-kappa B signaling pathway
umr04066  HIF-1 signaling pathway
umr04070  Phosphatidylinositol signaling system
umr04072  Phospholipase D signaling pathway
umr04360  Axon guidance
umr04370  VEGF signaling pathway
umr04380  Osteoclast differentiation
umr04611  Platelet activation
umr04613  Neutrophil extracellular trap formation
umr04625  C-type lectin receptor signaling pathway
umr04650  Natural killer cell mediated cytotoxicity
umr04662  B cell receptor signaling pathway
umr04664  Fc epsilon RI signaling pathway
umr04666  Fc gamma R-mediated phagocytosis
umr04670  Leukocyte transendothelial migration
umr04722  Neurotrophin signaling pathway
umr04750  Inflammatory mediator regulation of TRP channels
umr04919  Thyroid hormone signaling pathway
umr04933  AGE-RAGE signaling pathway in diabetic complications
umr04935  Growth hormone synthesis, secretion and action
umr05167  Kaposi sarcoma-associated herpesvirus infection
umr05169  Epstein-Barr virus infection
umr05170  Human immunodeficiency virus 1 infection
umr05171  Coronavirus disease - COVID-19
umr05200  Pathways in cancer
umr05205  Proteoglycans in cancer
umr05206  MicroRNAs in cancer
umr05214  Glioma
umr05223  Non-small cell lung cancer
umr05225  Hepatocellular carcinoma
Module
umr_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:umr00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    103662093 (PLCG2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    103662093 (PLCG2)
   04014 Ras signaling pathway
    103662093 (PLCG2)
   04370 VEGF signaling pathway
    103662093 (PLCG2)
   04064 NF-kappa B signaling pathway
    103662093 (PLCG2)
   04066 HIF-1 signaling pathway
    103662093 (PLCG2)
   04020 Calcium signaling pathway
    103662093 (PLCG2)
   04070 Phosphatidylinositol signaling system
    103662093 (PLCG2)
   04072 Phospholipase D signaling pathway
    103662093 (PLCG2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    103662093 (PLCG2)
   04613 Neutrophil extracellular trap formation
    103662093 (PLCG2)
   04625 C-type lectin receptor signaling pathway
    103662093 (PLCG2)
   04650 Natural killer cell mediated cytotoxicity
    103662093 (PLCG2)
   04662 B cell receptor signaling pathway
    103662093 (PLCG2)
   04664 Fc epsilon RI signaling pathway
    103662093 (PLCG2)
   04666 Fc gamma R-mediated phagocytosis
    103662093 (PLCG2)
   04670 Leukocyte transendothelial migration
    103662093 (PLCG2)
   04062 Chemokine signaling pathway
    103662093 (PLCG2)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    103662093 (PLCG2)
   04919 Thyroid hormone signaling pathway
    103662093 (PLCG2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    103662093 (PLCG2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    103662093 (PLCG2)
  09158 Development and regeneration
   04360 Axon guidance
    103662093 (PLCG2)
   04380 Osteoclast differentiation
    103662093 (PLCG2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103662093 (PLCG2)
   05206 MicroRNAs in cancer
    103662093 (PLCG2)
   05205 Proteoglycans in cancer
    103662093 (PLCG2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    103662093 (PLCG2)
   05214 Glioma
    103662093 (PLCG2)
   05223 Non-small cell lung cancer
    103662093 (PLCG2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    103662093 (PLCG2)
   05171 Coronavirus disease - COVID-19
    103662093 (PLCG2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    103662093 (PLCG2)
   05169 Epstein-Barr virus infection
    103662093 (PLCG2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    103662093 (PLCG2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103662093 (PLCG2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:umr04131]
    103662093 (PLCG2)
Enzymes [BR:umr01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     103662093 (PLCG2)
Membrane trafficking [BR:umr04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    103662093 (PLCG2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    103662093 (PLCG2)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y C2 SH3_1 PH SH3_9 PH_12 PH_14 SH3_2
Other DBs
NCBI-GeneID: 103662093
NCBI-ProteinID: XP_040489584
UniProt: A0A8M1GC35
LinkDB
Position
Unknown
AA seq 1216 aa
MTALVNVDTLPEYEKSQIKRALELGTVMTVFSFRKYTPERRTVQVIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTVLYGTQFVLSTLSLAADSKEDAT
KWLSGLKILHQEAMSASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLVNFKVNSA
KFLKDKFLEIGAHKDELSFEQFHLFYKNLMFEQQKSILDEFKKDSSVFILGNTDRPDASA
VYLHDFQRFLLHEQQELWAQDLTKVRERMTKFIHDTVRETAEPFLFVDEFLTYLFSRENS
IWDEKYDVVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYVRCLRMGCRCIELDC
WDGPDGKPIIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCCVEQQRHMARV
FKEVFGDQLLMKPTEASADQLPSPSQLRERIIIKHKKLGPRGDVDVNMEDKKDEHKQQGE
LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTAEEELPQDIPPTELHFGEEWFHKKVEKR
ASAEKLLQEYCAETGGKDGTFLVRESKTFPNDYTLSFWRSGRVQHCRIRSTMEGGTMKYF
LTDNLTFTSIYALIQHYRETHLRCTEFELRLTDPVPNPNPHESKPWYYDGLSRGEAEDML
MRVPRDGAFLIRRREGTDSYAITFRARGKVKHCRIHRDGRHFVLGTSAYFESLVELVSYY
EKHALYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
KAKRSDELSFCRGALIHNVSKEPWGWWKGDYGTRIQQYFPSNYVEDISTFDGEEMEKQII
EDNPLGSLCRGILDLNTYNVVKAPQGKNQKQFVFILEPKKQGDPPVEFATDKVEELFEWF
QSIREITWKMDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE
TKADSVVRQKPIDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTPDKY
MQMNHALFSLNGRTGYVLQPESMRSEKYDPMPPESQRKILMTLSVKVLGARHLPKLGRSI
ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPVWAATQEKVTFEIYDPNLAFLRFVVYEED
MFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMQPVLVSEETPVGVP
SAVCAGGVERAMGTVG
NT seq 3651 nt   +upstreamnt  +downstreamnt
atgaccgccctggtcaacgtggacacccttcctgagtacgagaagagtcagatcaagaga
gcgctggagctgggcacagtgatgacggtgttcagtttccgcaagtacaccccagagcgg
aggaccgtccaggtgatcatggagacgcgccaggtggcctggagcaagacagccgacaag
atcgagggcttcttggatatcatggaaatcaaggaaatccgcccagggaagaactccaag
gactttgagcgtgccaaagctgtccgccagaaggaagactgctgctttaccgtcctgtac
ggcacccagtttgttctcagcacgctcagcttggcagccgactccaaagaagatgcgact
aagtggctgtctggcttgaaaatcttacaccaggaagcaatgagcgcctccacacccacc
attattgagagttggctgagaaagcagatttattcagtggatcaaaccagaagaaacagc
atcagcctccgagagctgaagaccatcttacccctggtcaacttcaaagtgaacagtgcc
aagttcctcaaagataagtttctggaaatcggcgcgcacaaagatgaactcagcttcgag
cagttccacctgttctacaaaaaccttatgtttgagcaacaaaagtcgattcttgacgaa
ttcaaaaaagattcttctgtgttcatcttgggcaacaccgacaggccggacgcctccgcc
gtttacctgcacgacttccagcgctttctcttacacgagcagcaggagctttgggctcag
gatctgaccaaagtccgtgagcggatgactaagtttatccacgacaccgtgagggaaact
gctgagcccttcttgtttgtcgatgagttcctcacgtacctgttctcgcgggagaacagc
atctgggatgagaagtacgacgtggtggacatgcaggacatgaacaaccccttgtcgcat
tactggatctcctcttcgcataacacgtacctcaccggtgaccaactgcggagcgagtca
tccacggaagcgtacgtccgctgcctgcggatgggctgtcgctgcattgagctggactgc
tgggatgggcccgacgggaagcccatcatctaccacggctggacacggaccaccaagatc
aagtttgatgacgtcgtgcaggccatcaaagaccatgcctttgtcacttcaagcttccca
gtgatcctgtccatcgaggagcactgttgcgttgaacagcagcgccacatggccagggtg
ttcaaggaggtgtttggcgaccagctgctgatgaagcccacggaggccagtgctgaccag
ctgccctcgcccagccagctgcgggagaggataatcatcaagcataagaagctgggcccg
cgaggtgacgtggatgtcaacatggaggataagaaagatgagcacaaacaacagggtgaa
ctgtacatgtgggattccatcgaccagaagtggactcggcactactgtgccatcgctgat
gccaagctgtcgttcagcgacgacattgaacagactgcagaagaggaactgccccaggac
ataccccctacggagctgcactttggggaggagtggttccacaagaaggtggagaagagg
gcgagtgccgagaagctgctgcaggaatactgtgcggagacagggggcaaggatgggacc
ttcctggtgcgggagagcaagaccttccccaacgactacacgctgtccttctggcggtcc
ggccgggtccagcactgccggatccgttccaccatggagggcgggaccatgaagtacttc
ctgactgacaacctcacgttcaccagcatctatgccctcatccagcactaccgcgagacg
cacctgcgttgcacagagtttgagctccggctcaccgaccctgtgcccaaccccaacccc
cacgagtcaaagccgtggtactatgatgggctgagccgcggggaagcagaggacatgctc
atgagggttcctcgggatggcgccttcctgatccggaggcgggagggcaccgactcctac
gccatcaccttcagggccaggggcaaggtaaagcactgtcgcattcaccgggacggccgg
cactttgtgctggggacctcggcctactttgagagcctcgtggagctcgtcagctactac
gagaagcacgcgctctaccggaagatgcggctgcgctaccccgtgacgccggagctcctg
gagcgctacaatatggaaagagacataaactccctctatgacgtcagcagaatgtatgtg
gatcccagcgaaatcaatccttccatgcctcagagaaccgtgaaagctctgtatgactac
aaagccaagcgaagcgatgagctgagcttctgccgtggggccctcattcacaacgtctcc
aaggaaccctggggctggtggaaaggagactatgggaccagaatccagcagtacttccca
tccaattacgtcgaggacatttcaacattcgacggggaggagatggagaagcagattatt
gaagacaatcccttagggtctctttgtaggggaatattggatctcaacacctataacgtc
gtgaaagccccccaggggaaaaaccagaaacagttcgtgtttatcctggagcccaagaag
caaggcgaccccccagtcgagtttgccacggacaaggtggaggagctcttcgagtggttc
cagagcatccgggagatcacctggaagatggacaccaaggagaacaacatgaagtactgg
gagaagaaccagtccatcgccatcgagctctcggacctggtagtttactgcaagccgacc
agcaagaccaaggataatctagaaaaccccgacttccgagaaatccgctcctttgtggag
acgaaggcggacagtgtcgtcaggcagaaacccatcgacctcctgaagtacaatcagaag
ggcctgacccgtgtttacccaaagggacagagggtggactcctccaactacgaccccttt
cgcctctggctgtgcggctcccagatggtggcactcaacttccagacgccagacaagtac
atgcagatgaatcacgccttgttctcactcaacgggcggacgggctacgtcctccagcct
gagagcatgaggtccgagaagtatgaccccatgccaccggagtcccagaggaagatcctg
atgactctgtcagtcaaggttctcggggctcgccatctccccaagcttggacgaagtatt
gcgtgtccctttgtggaggtggaaatctgcggagccgaatatgacaacaacaagtttaag
acaacagttgtgaatgacaatggcctaagtcctgtttgggctgcaacacaggagaaagtg
acctttgaaatttacgaccccaacctggcatttctgcgctttgtggtctacgaggaagat
atgttcagtgatcccaatttcctcgcccacgccacttaccccatcaaaggaatcaaatca
ggattcagatctgttcctctgaagaacgggtacagcgaagacattgagctggcttccctc
ctggttttctgtgagatgcagccagtcctggtgagtgaagaaacgcccgttggggttccc
tcagctgtgtgtgctggtggggttgaaagggctatgggtaccgttggctga

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