Ursus maritimus (polar bear): 103674675 Help Entry 103674675         CDS       T03271                                  Symbol ADCY1 Name (RefSeq) adenylate cyclase type 1   KO K08041   adenylate cyclase 1 [EC:4.6.1.1] Organism umr  Ursus maritimus (polar bear) Pathway umr00230   Purine metabolism umr01100   Metabolic pathways umr01522   Endocrine resistance umr04015   Rap1 signaling pathway umr04020   Calcium signaling pathway umr04022   cGMP-PKG signaling pathway umr04024   cAMP signaling pathway umr04062   Chemokine signaling pathway umr04072   Phospholipase D signaling pathway umr04114   Oocyte meiosis umr04211   Longevity regulating pathway umr04213   Longevity regulating pathway - multiple species umr04261   Adrenergic signaling in cardiomyocytes umr04270   Vascular smooth muscle contraction umr04371   Apelin signaling pathway umr04540   Gap junction umr04611   Platelet activation umr04713   Circadian entrainment umr04714   Thermogenesis umr04720   Long-term potentiation umr04723   Retrograde endocannabinoid signaling umr04724   Glutamatergic synapse umr04725   Cholinergic synapse umr04727   GABAergic synapse umr04750   Inflammatory mediator regulation of TRP channels umr04911   Insulin secretion umr04912   GnRH signaling pathway umr04913   Ovarian steroidogenesis umr04914   Progesterone-mediated oocyte maturation umr04915   Estrogen signaling pathway umr04916   Melanogenesis umr04918   Thyroid hormone synthesis umr04921   Oxytocin signaling pathway umr04923   Regulation of lipolysis in adipocytes umr04925   Aldosterone synthesis and secretion umr04926   Relaxin signaling pathway umr04927   Cortisol synthesis and secretion umr04928   Parathyroid hormone synthesis, secretion and action umr04934   Cushing syndrome umr04935   Growth hormone synthesis, secretion and action umr04970   Salivary secretion umr04971   Gastric acid secretion umr04972   Pancreatic secretion umr04976   Bile secretion umr05032   Morphine addiction umr05142   Chagas disease umr05146   Amoebiasis umr05163   Human cytomegalovirus infection umr05166   Human T-cell leukemia virus 1 infection umr05200   Pathways in cancer umr05207   Chemical carcinogenesis - receptor activation umr05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:umr00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     103674675 (ADCY1)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     103674675 (ADCY1)    04371 Apelin signaling pathway     103674675 (ADCY1)    04020 Calcium signaling pathway     103674675 (ADCY1)    04072 Phospholipase D signaling pathway     103674675 (ADCY1)    04024 cAMP signaling pathway     103674675 (ADCY1)    04022 cGMP-PKG signaling pathway     103674675 (ADCY1)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     103674675 (ADCY1)   09144 Cellular community - eukaryotes    04540 Gap junction     103674675 (ADCY1)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     103674675 (ADCY1)    04062 Chemokine signaling pathway     103674675 (ADCY1)   09152 Endocrine system    04911 Insulin secretion     103674675 (ADCY1)    04923 Regulation of lipolysis in adipocytes     103674675 (ADCY1)    04912 GnRH signaling pathway     103674675 (ADCY1)    04913 Ovarian steroidogenesis     103674675 (ADCY1)    04915 Estrogen signaling pathway     103674675 (ADCY1)    04914 Progesterone-mediated oocyte maturation     103674675 (ADCY1)    04921 Oxytocin signaling pathway     103674675 (ADCY1)    04926 Relaxin signaling pathway     103674675 (ADCY1)    04935 Growth hormone synthesis, secretion and action     103674675 (ADCY1)    04918 Thyroid hormone synthesis     103674675 (ADCY1)    04928 Parathyroid hormone synthesis, secretion and action     103674675 (ADCY1)    04916 Melanogenesis     103674675 (ADCY1)    04925 Aldosterone synthesis and secretion     103674675 (ADCY1)    04927 Cortisol synthesis and secretion     103674675 (ADCY1)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     103674675 (ADCY1)    04270 Vascular smooth muscle contraction     103674675 (ADCY1)   09154 Digestive system    04970 Salivary secretion     103674675 (ADCY1)    04971 Gastric acid secretion     103674675 (ADCY1)    04972 Pancreatic secretion     103674675 (ADCY1)    04976 Bile secretion     103674675 (ADCY1)   09156 Nervous system    04724 Glutamatergic synapse     103674675 (ADCY1)    04727 GABAergic synapse     103674675 (ADCY1)    04725 Cholinergic synapse     103674675 (ADCY1)    04720 Long-term potentiation     103674675 (ADCY1)    04723 Retrograde endocannabinoid signaling     103674675 (ADCY1)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     103674675 (ADCY1)   09149 Aging    04211 Longevity regulating pathway     103674675 (ADCY1)    04213 Longevity regulating pathway - multiple species     103674675 (ADCY1)   09159 Environmental adaptation    04713 Circadian entrainment     103674675 (ADCY1)    04714 Thermogenesis     103674675 (ADCY1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103674675 (ADCY1)    05207 Chemical carcinogenesis - receptor activation     103674675 (ADCY1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     103674675 (ADCY1)    05163 Human cytomegalovirus infection     103674675 (ADCY1)   09174 Infectious disease: parasitic    05146 Amoebiasis     103674675 (ADCY1)    05142 Chagas disease     103674675 (ADCY1)   09165 Substance dependence    05032 Morphine addiction     103674675 (ADCY1)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     103674675 (ADCY1)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     103674675 (ADCY1)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     103674675 (ADCY1) Enzymes [BR:umr01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      103674675 (ADCY1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc AC_N Adcy_cons_dom DUF6688 HNOBA Motif Other DBs NCBI-GeneID:  103674675 NCBI-ProteinID:  XP_040500424 UniProt:  A0A8M1H4N6 LinkDB All DBs Position Unknown AA seq 908 aa AA seqDB search MYGVFVRVLAERSQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLK PPERIFHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCR RIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVL CGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGHGHERNSF LKAHNIETFFIVPSHRRKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFS NVMTCEDDDKRRALRTASEKLRNRSSFSANVVYTTPGTRVNRYIGRLLEARQMELEMADL DFFTLKYKQAERERKYHQLQDEYFTSAVVLALVLAALFGLVYLLIIPQSVVVLLLLVFCI CFLVACVLYLHITRVQCFPGCLTIQIRTVLCIFIVVLIYSVAQGCVVGCLPWAWSSSPNR SLVTVLTPGGRNAVLPAAPCESAPHALLCGLVGTLPLAIFLRVSSLPKMILLFVLTASYI LVLELSGYTRASGGGAVSGRSFEPIVAILLFSCTLALHARQVDIKLRLDYLWAAQAEEER DDMERVKLDNKRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFDDFYIE LDGNNMGVECLRLLNEIIADFDELMDKDFYKDLEKIKTIGSTYMAAVGLAPTTGTKAKKC ISSHLSTLADFAIEMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTV NVASRMDSTGVQGRIQVTEDVHRLLRRGTYRFVCRGKVSVKGKGEMLTYFLEGRTDANGS QARSLNAERKMCAYGRAGLQTRLATGPPPVGPMIGHPVRAGLGSLQGSGLPPGPHGQHPP PGAAGKEA NT seq 2727 nt NT seq  +upstreamnt  +downstreamnt atgtacggggtgtttgtgagggtcctggccgaacgctcccaaaggaaagccttcttgcag gcccggaactgcatcgaagatcggctgaggctggaggacgagaacgagaagcaggagcgg ctgcttatgagccttctgccccggaatgttgccatggagatgaaggaggacttcctgaag ccccctgagaggattttccacaagatttacatccagcggcatgacaacgtgagcatcctc tttgcggacatcgtgggcttcacgggcctggcgtcacagtgcacggcgcaggagctggtg aagctgctcaacgagctcttcggcaagtttgatgaactggccacggagaaccactgtcgc cggatcaagatccttggggactgctattactgcgtgtctggcctcacccagcccaagacc gaccacgcccactgctgcgtggagatgggtctggacatgatcgacaccatcacgtcggtg gcagaggccacggaggtggatctgaacatgcgtgtggggctgcacaccggccgggtcctc tgcggggtcctcggcctgcgcaagtggcagtatgacgtgtggtccaatgacgtgaccctg gccaatgtaatggaggccgctggcctgcccgggaaggtccacatcacgaagacgaccctg gcgtgcttgaacggtgactatgaggtggagccggggcacgggcacgagaggaacagcttt ctgaaagctcacaacatcgagaccttcttcatcgtgccgtcacatcggcggaagatcttt ccagggctgatcctttcggacataaagcccgccaagaggatgaagttcaagaccgtgtgc tacctgctggtgcagctcatgcactgtcggaagatgttcaaggcggagatccccttctcc aacgtcatgacgtgcgaggatgacgacaagcggagggcgttgagaactgcgtcagaaaaa ctcagaaaccgctcgtccttctctgcgaatgttgtctacaccaccccgggcacgcgcgtc aacaggtacatcggccgcctcctagaagcacgccagatggagctggagatggcggacctg gacttcttcaccctgaagtataagcaggctgagcgcgagcgcaagtaccaccagctccag gacgagtatttcaccagtgccgtcgtgcttgcgctcgtcctggctgccttgtttggcctc gtctaccttctcatcatcccgcagagcgtggtcgtcctcctgctgctggtgttctgcatc tgcttcctggtggcctgtgtcctgtacctgcacatcacccgggtccagtgttttccagga tgcctgacgatccagatccgcaccgtcttgtgtattttcatagtggtcctcatctactcg gtggcccaaggatgtgtggtgggctgcctgccctgggcctggagctccagccccaacagg tccctggtgaccgtcctgacccctggtggccggaacgccgtgctgcctgctgcaccctgc gagtctgcaccccacgccctgctctgtggcctcgtgggcaccctgccactggccatcttc ctgcgggtgtcctccctgcccaaaatgatcctgctcttcgtgctcacggcgtcctacatc ctggtcctggagctcagcgggtacaccagggcctcagggggcggtgcggtgtccgggcgc agcttcgagccgatcgtggccatcctgctgttctcgtgcacgctggccctgcacgcccgg caggtggacatcaagctgcggctggactatctctgggcagcacaggcagaggaggagagg gacgacatggagagggtgaagctggacaacaagaggattctcttcaacctcctgccagcc cacgtcgcccagcacttcctcatgtccaacccccggaacatggacctgtactaccagtcc tactcgcaggtgggcgtcatgttcgcctccatccccaactttgatgacttctacatcgag ctggatggcaacaacatgggggtggagtgtctgcgccttctgaatgagatcatcgctgac tttgacgagctcatggacaaagacttctacaaggacctggagaagatcaagaccatcggg agcacctatatggctgcggtgggactagcacccacgaccgggaccaaggcaaagaagtgc atctcctcgcacctcagcacgctggcggactttgccatcgagatgttcgacgtcctggat gaaatcaactaccagtcttacaacgactttgtgctccgtgtcggcatcaacgttggcccc gtggtggccggggtgatcggggctcgaaggccgcagtacgacatctggggaaacacggtc aatgtggccagtaggatggacagcacgggtgtccagggcagaatccaggtgaccgaggac gttcaccggctgctgcgaaggggcacttaccgcttcgtgtgccgcgggaaggtcagcgtc aagggcaagggtgagatgctgacgtacttcctggaaggccggaccgatgcaaacggctcc caggccaggtccctgaatgcagagcggaaaatgtgcgcttacgggcgagccggcctccag accagactggccacaggcccgcccccggtgggccccatgatcggccacccggtcagagcc gggctggggtctctgcagggctcggggctccccccaggcccccacggccagcacccgccc cccggagcagctggaaaggaggcttag

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