Ursus maritimus (polar bear): 103678826 Help Entry 103678826         CDS       T03271                                  Symbol ADCY5 Name (RefSeq) adenylate cyclase type 5   KO K08045   adenylate cyclase 5 [EC:4.6.1.1] Organism umr  Ursus maritimus (polar bear) Pathway umr00230   Purine metabolism umr01100   Metabolic pathways umr01522   Endocrine resistance umr04015   Rap1 signaling pathway umr04022   cGMP-PKG signaling pathway umr04024   cAMP signaling pathway umr04062   Chemokine signaling pathway umr04072   Phospholipase D signaling pathway umr04114   Oocyte meiosis umr04211   Longevity regulating pathway umr04213   Longevity regulating pathway - multiple species umr04261   Adrenergic signaling in cardiomyocytes umr04270   Vascular smooth muscle contraction umr04371   Apelin signaling pathway umr04540   Gap junction umr04611   Platelet activation umr04713   Circadian entrainment umr04714   Thermogenesis umr04723   Retrograde endocannabinoid signaling umr04724   Glutamatergic synapse umr04725   Cholinergic synapse umr04726   Serotonergic synapse umr04727   GABAergic synapse umr04728   Dopaminergic synapse umr04750   Inflammatory mediator regulation of TRP channels umr04911   Insulin secretion umr04912   GnRH signaling pathway umr04913   Ovarian steroidogenesis umr04914   Progesterone-mediated oocyte maturation umr04915   Estrogen signaling pathway umr04916   Melanogenesis umr04918   Thyroid hormone synthesis umr04921   Oxytocin signaling pathway umr04923   Regulation of lipolysis in adipocytes umr04924   Renin secretion umr04925   Aldosterone synthesis and secretion umr04926   Relaxin signaling pathway umr04927   Cortisol synthesis and secretion umr04928   Parathyroid hormone synthesis, secretion and action umr04934   Cushing syndrome umr04935   Growth hormone synthesis, secretion and action umr04970   Salivary secretion umr04971   Gastric acid secretion umr04972   Pancreatic secretion umr04976   Bile secretion umr05012   Parkinson disease umr05030   Cocaine addiction umr05031   Amphetamine addiction umr05032   Morphine addiction umr05034   Alcoholism umr05163   Human cytomegalovirus infection umr05166   Human T-cell leukemia virus 1 infection umr05200   Pathways in cancer umr05207   Chemical carcinogenesis - receptor activation umr05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:umr00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     103678826 (ADCY5)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     103678826 (ADCY5)    04371 Apelin signaling pathway     103678826 (ADCY5)    04072 Phospholipase D signaling pathway     103678826 (ADCY5)    04024 cAMP signaling pathway     103678826 (ADCY5)    04022 cGMP-PKG signaling pathway     103678826 (ADCY5)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     103678826 (ADCY5)   09144 Cellular community - eukaryotes    04540 Gap junction     103678826 (ADCY5)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     103678826 (ADCY5)    04062 Chemokine signaling pathway     103678826 (ADCY5)   09152 Endocrine system    04911 Insulin secretion     103678826 (ADCY5)    04923 Regulation of lipolysis in adipocytes     103678826 (ADCY5)    04912 GnRH signaling pathway     103678826 (ADCY5)    04913 Ovarian steroidogenesis     103678826 (ADCY5)    04915 Estrogen signaling pathway     103678826 (ADCY5)    04914 Progesterone-mediated oocyte maturation     103678826 (ADCY5)    04921 Oxytocin signaling pathway     103678826 (ADCY5)    04926 Relaxin signaling pathway     103678826 (ADCY5)    04935 Growth hormone synthesis, secretion and action     103678826 (ADCY5)    04918 Thyroid hormone synthesis     103678826 (ADCY5)    04928 Parathyroid hormone synthesis, secretion and action     103678826 (ADCY5)    04916 Melanogenesis     103678826 (ADCY5)    04924 Renin secretion     103678826 (ADCY5)    04925 Aldosterone synthesis and secretion     103678826 (ADCY5)    04927 Cortisol synthesis and secretion     103678826 (ADCY5)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     103678826 (ADCY5)    04270 Vascular smooth muscle contraction     103678826 (ADCY5)   09154 Digestive system    04970 Salivary secretion     103678826 (ADCY5)    04971 Gastric acid secretion     103678826 (ADCY5)    04972 Pancreatic secretion     103678826 (ADCY5)    04976 Bile secretion     103678826 (ADCY5)   09156 Nervous system    04724 Glutamatergic synapse     103678826 (ADCY5)    04727 GABAergic synapse     103678826 (ADCY5)    04725 Cholinergic synapse     103678826 (ADCY5)    04728 Dopaminergic synapse     103678826 (ADCY5)    04726 Serotonergic synapse     103678826 (ADCY5)    04723 Retrograde endocannabinoid signaling     103678826 (ADCY5)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     103678826 (ADCY5)   09149 Aging    04211 Longevity regulating pathway     103678826 (ADCY5)    04213 Longevity regulating pathway - multiple species     103678826 (ADCY5)   09159 Environmental adaptation    04713 Circadian entrainment     103678826 (ADCY5)    04714 Thermogenesis     103678826 (ADCY5)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103678826 (ADCY5)    05207 Chemical carcinogenesis - receptor activation     103678826 (ADCY5)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     103678826 (ADCY5)    05163 Human cytomegalovirus infection     103678826 (ADCY5)   09164 Neurodegenerative disease    05012 Parkinson disease     103678826 (ADCY5)   09165 Substance dependence    05030 Cocaine addiction     103678826 (ADCY5)    05031 Amphetamine addiction     103678826 (ADCY5)    05032 Morphine addiction     103678826 (ADCY5)    05034 Alcoholism     103678826 (ADCY5)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     103678826 (ADCY5)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     103678826 (ADCY5)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     103678826 (ADCY5) Enzymes [BR:umr01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      103678826 (ADCY5) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  AC_N Guanylate_cyc Adcy_cons_dom TBK1_ULD GBR2_CC Motif Other DBs NCBI-GeneID:  103678826 NCBI-ProteinID:  XP_008706469 UniProt:  A0A384DI42 LinkDB All DBs Position Unknown AA seq 1117 aa AA seqDB search AAAAGGTEVRPRSVELGLEERRGKGRAVDELEAGAVDGDEGSGDGGSSAESGAGPGAVLS LGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAFHAARP PLQLPYLAVLAAAVGVILVMAVLCNRAAFHQDHMGLACYALIAVVLAVQVVGLLLPQPRS ASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSALHLAIALRTNARDQFLLKQLVSNVL IFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEM KADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKL AAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVG IHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGC GGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHL GGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTF REPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSVFMLSFYLTCFLLLTLVV FVSVIYSCVKLFPGPLQTLSRKIVRSKMNSTLVGVFTITLVFLSAFVNMFTCNSNDLFGC LADEHNISTSQVNACHVVESAANYSLGDERGFCSSPWPNCNFPEYFTYSVLLSLLACSVF LQISCIGKLVLMLAIELTYVLIVEVPRVTLFDNADLLVTANAIDFNNNGTSQCPEHATKV ALKVMTPIVISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNIL PKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEII ADFDEIISEDRFKQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQMKY INEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDM YQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS NT seq 3354 nt NT seq  +upstreamnt  +downstreamnt gcggccgcggccggcgggacggaggtgcgccctcggtcggtggagctgggcctggaggag cggcggggcaagggccgcgcggtggacgagctggaggccggcgccgtcgacggcgacgaa gggtccggggatggcggcagctcggcagaatcaggcgcggggcccggcgcagtgctgtcg ctgggtgcctgctgcctggcgctgctgcagatattccgttccaagaagttcccgtcggac aagctggagcggctgtaccagcgctacttcttccgtctgaaccagagcagcctcactatg ctcatggccgtgctggtgctcgtgtgcctcgtcatgttggccttccacgcggcgcggccc ccgctccagctgccctacctggcagtgctggcggctgcggtaggtgtcatcctcgtcatg gctgtgctctgcaaccgcgccgccttccaccaggaccacatgggcctggcctgctacgcg ctcatcgccgtggtgctggccgtccaggtggtgggcctgctgctgccccagccgcgcagc gcctccgagggcatctggtggaccgtgttcttcatctacaccatctacacgttgctgcct gtgcgcatgcgggccgcggtactcagtggagtgctcctttctgcactccacctggccatc gccctgcgcaccaacgcccgggaccagttcctgctcaagcagcttgtctccaatgtcctc attttctcctgcaccaacattgtgggtgtttgcacccactacccggctgaagtctcccag agacaggccttccaggagacccgggagtgcatccaggcacggctccactcacaacgggag aaccagcaacaggagcggctcctgctgtctgtcctgccccgtcatgttgccatggagatg aaagcagacatcaatgccaagcaggaggatatgatgttccataagatttacatccagaaa cacgacaacgtgagcatcctgtttgctgacatcgagggcttcaccagcctggcatcccag tgcactgcccaggagctggtcatgaccctcaacgagctcttcgcccgcttcgacaagctg gctgcggagaatcactgtttacgtattaagatcctgggggattgttattactgtgtctct gggctgcctgaagcgagggctgaccacgcccactgctgcgtggagatgggcatggacatg attgaggccatctcgttggtccgggaggtgacaggggtgaacgtgaacatgcgcgtggga attcacagcgggcgagtacactgcggtgtccttggtctcaggaagtggcaattcgacgtc tggtctaatgacgtcacgctggccaaccacatggaagctggaggcaaggcagggcgcatc cacatcaccaaggccacactcaactacctgaacggggactacgaggtggagccgggctgt gggggcgagcgtaacgcctacctcaaggaacacagtatcgagaccttcctcatcctgcgc tgcacccagaagcggaaagaagaaaaggccatgatcgccaagatgaatcgccagagaacc aactccattgggcacaacccgccccactggggggccgagcgtcccttctacaaccacctg gggggcaaccaggtgtccaaggagatgaagcggatgggcttcgaagaccccaaggacaag aacgcccaagaaagcgcaaaccctgaggacgaagtggacgaatttctgggccgtgccatt gacgccaggagcatcgacaggctgcggtctgagcatgtccgcaagttcctcttgaccttc agggagcctgacttagagaagaagtactccaagcaggtggatgaccgattcggtgcctac gtggcatgtgcctcgcttgtcttcctcttcatctgctttgtccagatcaccatcgtgccc cactccgtgttcatgttgagtttctacctaacctgtttcctgctgctgacgttagtggta tttgtgtccgtgatctattcctgcgtgaagctgttccccggcccactgcagaccctctcc aggaagattgtgcggtccaagatgaacagcactctggttggcgtgttcaccatcaccctc gtgttcctctcggcttttgtcaacatgttcacgtgtaactccaacgacctgttcggctgc ctggcggatgagcacaacatcagcaccagccaggtcaacgcgtgccacgtggtggagtcg gccgccaactacagcctgggggacgagcggggcttctgcagcagcccgtggcccaactgc aacttccctgagtacttcacctacagcgtgctgctcagcctgctggcctgctccgtgttc ctgcagatcagctgcattgggaagctggtgctcatgctggccattgagctcacatacgtg ctcatcgtcgaggtgccccgagtcacgctctttgacaatgccgacctgctggttaccgcc aatgccatagacttcaacaacaacgggacctcccagtgccctgagcatgcgaccaaggtg gcgctgaaggtgatgacgcccatcgtcatctccgtctttgtgctggccctgtacctgcac gcccagcaagtggagtccaccgcccgcctggacttcctctggaaactgcaggccacggag gagaaggaggagatggaggagctgcaggcctacaaccggcggctgctgcacaacatcctg cccaaggacgtggctgcccacttcctggcccgcgagcggcgcaacgacgagctctactac cagtcgtgcgagtgcgtggccgtcatgtttgcctccatcgccaacttctccgagttctat gtggagctggaggccaacaatgagggcgtcgagtgcctgcggctgctcaatgagatcatc gccgactttgacgagatcatcagtgaggatcggttcaagcagctggagaagatcaagacc attggcagcacctacatggccgcctcaggcctcaacgactctacgtatgacaaggtgggc aagacccacatcaaagccctggccgacttcgccatgaagctcatggaccaaatgaagtac atcaatgaacactccttcaacaacttccagatgaagatcgggctcaacatcggccctgtg gtggccggggtgatcggggctcgcaagccgcagtacgacatctggggcaatacggtgaac gtggccagccgcatggacagcaccggtgtgcccgaccgcatccaggtcaccacggacatg taccaggtgctggctgccaacacataccagctggagtgcaggggtgtggtcaaggtcaag ggcaaaggcgagatgatgacctacttcctcaacgggggccccccgctcagttag

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