Xiphophorus hellerii (green swordtail): 116713016
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Entry
116713016 CDS
T07363
Symbol
gclc
Name
(RefSeq) glutamate--cysteine ligase catalytic subunit
KO
K11204
glutamate--cysteine ligase catalytic subunit [EC:
6.3.2.2
]
Organism
xhe
Xiphophorus hellerii (green swordtail)
Pathway
xhe00270
Cysteine and methionine metabolism
xhe00480
Glutathione metabolism
xhe01100
Metabolic pathways
xhe01240
Biosynthesis of cofactors
xhe04216
Ferroptosis
Module
xhe_M00118
Glutathione biosynthesis, glutamate => glutathione
Brite
KEGG Orthology (KO) [BR:
xhe00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
116713016 (gclc)
09106 Metabolism of other amino acids
00480 Glutathione metabolism
116713016 (gclc)
09140 Cellular Processes
09143 Cell growth and death
04216 Ferroptosis
116713016 (gclc)
Enzymes [BR:
xhe01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
116713016 (gclc)
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Motif
Pfam:
GCS
GCS2
Motif
Other DBs
NCBI-GeneID:
116713016
NCBI-ProteinID:
XP_032408804
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Position
22:13684845..13697914
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AA seq
630 aa
AA seq
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MGLLSQGSPLNWEETRKYADHIRKHGIIQFLNIYNKVKDRQRDVLKWGDEVEYMLVELDD
NDEKVRLVLNGGDVLETLQEQGENTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV
EGNMRKRRLEASSVLKKNMTLCTITSFPRLGCPGFTKPEYRPTPVEKGVSKSLFFPDEAI
NRHPRFSTLTRNIRHRRGEKVVINVPIYKDKHTPSPFVEQFPEDDGEAARAALPDHIYMD
AMGFGMGNCCLQVTFQACSIDEARYLYDQLATFCPIVMALSAASPFYRGYMSDIDCRWGV
ISASVDDRTQEERGLEPLKNNKYRIFKSRYDSIDSYLSCCGEKYNDIDLTIDEEINKQLL
SAGIDKLLAQHIAHLFIRDPLSVFEEKIHLDDENESDHFENLQSTNWQTMRFKPPPPNSD
IGWRVEFRPMEVQLTDFENAAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRNAV
QEGMFYFRKDMFKGCNPGLDCASSAQNGVEFEGSNEDYTLMSIDTIINGKEGVFQGLIPI
LNSYLENMEVDVDTRCTILNYLKLIKKRASGELMTMAKWMREFVAKHPEYKQDSVITDKI
NYDLLKRCDRIAKGEEQCPELFGNPVNRVK
NT seq
1893 nt
NT seq
+upstream
nt +downstream
nt
atggggttactgtcacaaggatctcccctgaactgggaagaaacaaggaagtatgccgac
cacatccgaaagcatggcatcatccagttcctcaacatctacaataaggtcaaggatcgt
cagagagatgtgttgaagtggggtgacgaggttgagtacatgctggtggagctggatgac
aatgatgagaaggttcgactggtgctgaatggtggagatgttttggaaactctccaagaa
cagggagaaaatacaaacccgaatcatccaacactttggagaccagagtatggcagctac
atgatcgagggaacgcctgggcagccgtacgggggaacgatgtccgagttcaacacggtg
gagggcaacatgaggaagagacgtctggaggcttcgtctgtcctgaagaagaatatgacg
ctctgcaccatcacctcctttccaaggttaggttgtccaggtttcaccaaaccagagtac
cgacccactcccgttgaaaagggagtgtcaaagtctttgtttttcccagatgaagccata
aacagacaccccagattcagcactctgaccagaaatatacgccatcgaagaggagagaaa
gttgtgataaatgtgccaatctacaaagataagcacacaccctctccatttgtggagcag
ttccctgaggatgacggcgaagcagcgagggcagcccttcctgaccacatctatatggac
gccatgggcttcggcatgggcaactgctgcctgcaagtgacattccaagcttgcagcatt
gatgaggcaaggtatctttatgaccaactagcaacattctgccccatcgtgatggcactg
agtgctgcctcacccttctacagagggtacatgtctgatattgattgtcgttggggagtt
atctcagcctcagtggatgacaggacccaagaggaacgaggcctggagcctctgaagaac
aacaagtacaggatctttaagtccaggtatgactcgattgacagctacctgtcttgctgt
ggggagaagtacaatgacatcgatttgactatagatgaagagatcaacaagcagctgctc
agtgcagggattgacaagcttctggctcaacacatagctcacctcttcatacgagacccg
ctctccgtgtttgaggagaaaatacatttggatgatgaaaacgaatcggatcactttgag
aatcttcagtcgaccaactggcagacgatgcggttcaaacctccacctccgaactccgac
atcggctggagagttgagtttcgccccatggaggttcagctaactgactttgaaaatgct
gcatatgtggtttttgttgtcctgcttaccagagtgatcttatcctacaagctggatttc
ctaatccccttatcaaaggtcgatgagaacatgaaggtggcgcagaagagaaacgcagtc
caggagggcatgttttatttccgcaaagacatgtttaaaggctgcaacccaggcttggac
tgtgcttcttctgctcagaacggcgtagagtttgagggcagcaacgaggattacacactg
atgagcatcgacacaatcatcaacgggaaggagggagtatttcaaggccttatcccaatc
cttaactcctatctggaaaacatggaagttgatgttgacaccagatgcactattttgaat
tatctgaagctcatcaagaaacgtgcctcaggagaactgatgaccatggccaagtggatg
agggaatttgttgcaaaacaccctgagtacaagcaggacagtgtcattactgacaagatc
aactacgacctgctcaaaaggtgcgacaggattgctaaaggcgaagagcagtgccccgag
ctttttggtaacccagtcaaccgagtgaagtga
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