Xenopus laevis (African clawed frog): 100049719
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Entry
100049719 CDS
T01010
Symbol
gclc.L
Name
(RefSeq) glutamate-cysteine ligase, catalytic subunit L homeolog
KO
K11204
glutamate--cysteine ligase catalytic subunit [EC:
6.3.2.2
]
Organism
xla
Xenopus laevis (African clawed frog)
Pathway
xla00270
Cysteine and methionine metabolism
xla00480
Glutathione metabolism
xla01100
Metabolic pathways
xla01240
Biosynthesis of cofactors
xla04216
Ferroptosis
Module
xla_M00118
Glutathione biosynthesis, glutamate => glutathione
Brite
KEGG Orthology (KO) [BR:
xla00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
100049719 (gclc.L)
09106 Metabolism of other amino acids
00480 Glutathione metabolism
100049719 (gclc.L)
09140 Cellular Processes
09143 Cell growth and death
04216 Ferroptosis
100049719 (gclc.L)
Enzymes [BR:
xla01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
100049719 (gclc.L)
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Motif
Pfam:
GCS
Motif
Other DBs
NCBI-GeneID:
100049719
NCBI-ProteinID:
NP_001092146
Xenbase:
XB-GENE-17336814
UniProt:
A0JMW1
A0A974CXI2
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Position
5L:101258586..101287523
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AA seq
637 aa
AA seq
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MGLLSHGSPLSWEETKKYADHVRQHGIIQFLHIYHKLKERQKDVLKWGDEVEYMLVSFDH
SNKKARLLLKGGEILDTLQNRGEKINPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV
EDNMRKRRQEATSLLLENNSLCSITTFPRLGCPGFTMPEFPPTPVEQGASKSLFFPDQAI
NKHPRFSTLTRNIRHRRGEKVAINVPIFKDQNTPSPFIERFPNVSDSEAVAAKPDHIYMD
AMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIMMALSAAAPFYRGYVSDIDCRWGV
ISASVDDRTKEERGLEPLKNNKYRISKSRYDSIDSYLSKCGEKYNDIELTIDKEIYTQLI
TEGIDHLLAQHIAHLFIRDPLTLFEENIHLDDANESDHFENIQSTNWQTMRFKPPPPNSD
IGWRVEFRPVEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKMAQKRDAV
RQGMFYFRKDISKAGIAVVDGCCSTQNGMESDPEECTLMSIDTIINGKEGVFPGLIPILN
SYLENMEVDVDTRCTILNYLKLIKKRASGELMTCARWMREFVTSHPEYKKDSVITDKINY
DLLVKCNQIANDQTACPELLGVTVNKSKPIGSQSVLV
NT seq
1914 nt
NT seq
+upstream
nt +downstream
nt
atgggtctgctgtcacatgggtctcctcttagctgggaagagaccaagaaatacgccgac
catgtccggcaacacggcatcatccagttcctgcacatctaccacaagttgaaagagcgg
caaaaggacgtgctgaaatggggagacgaggtggagtacatgctggtatctttcgaccat
tctaataaaaaagctcgtttgcttcttaaaggaggagagatactcgacactcttcaaaac
agaggtgaaaaaataaatccaaatcatccaaccctttggaggcctgaatatgggagttac
atgattgaagggactcctggacaaccttatggcggaaccatgtctgagtttaacaccgtg
gaagacaatatgagaaaacggcgccaagaagcaacatctttgctgttagaaaataattct
ctttgcagcattaccaccttcccacgattgggatgtccagggttcactatgcctgagttt
ccaccaacacccgtggaacagggtgcctccaaatctctattctttccagatcaggctatc
aataaacatcccaggtttagtacattgactagaaatattcgacacagacggggtgaaaaa
gttgccattaatgtaccaatttttaaagaccaaaacacaccatctccatttattgaaagg
tttccaaatgtcagtgacagtgaagcagtagctgctaaaccagaccacatctacatggat
gctatgggatttggcatggggaactgctgccttcaggtaacattccaggcctgcagcatt
tctgaagccaggtatctttatgaccagctagctacaatatgtcctattatgatggctctg
agtgcagcagctccattttacagaggatatgtgtctgatatagactgccgctggggagtg
atctctgcatcagtagatgatcgtaccaaagaagaaagagggttggaacctttaaaaaat
aacaaatacagaatcagtaaatctcgatatgattccatagacagttatttgtctaaatgt
ggagagaaatacaatgacattgagttgaccatcgataaagaaatctacactcagttaata
acagaagggattgatcacctgttagcgcagcacattgcacatctctttattagagatcct
ttaacattgtttgaggaaaatatacatctagatgatgccaatgaatctgaccattttgag
aacattcaatcaacaaactggcagactatgaggtttaaacctcccccaccaaattctgac
attggatggagggtagagtttcgtccagtggaggtccaattgacagactttgaaaactct
gcatatgttgtatttgtggtgctgcttaccagagtaattctgtcctacaaactggatttt
ctcattcctttgtcaaaggttgatgagaacatgaagatggcgcagaaacgagatgcggtg
cgacaaggaatgttttacttcaggaaagatatctcaaaagctggaattgcagttgttgat
ggctgttgttctacacaaaacggaatggaaagtgacccagaagaatgcacattgatgagc
attgatacaataatcaatggaaaggaaggtgtttttccaggcttaattccaatacttaat
tcataccttgaaaatatggaggtggatgttgatacgcgctgcaccatcttgaattatctt
aaactcattaaaaaaagagcttcaggtgagttaatgacttgcgcaagatggatgagagag
tttgttacaagccacccagagtacaagaaggacagtgtcattactgacaaaatcaattat
gatctactggtgaaatgtaaccaaattgcaaatgaccagactgcctgcccagagcttctt
ggggttacagtgaataaatccaagccaattggcagtcagtctgttcttgtatga
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