KEGG    Network variation - Lysine degradation
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ENTRYnt06036
NameLysine degradation
CategoryPathway view; Amino acid metabolism
Pathwayhsa00310 Lysine degradation
hsa00760 Nicotinate and nicotinamide metabolism
hsa00380 Tryptophan metabolism
Modulehsa_M00032 Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
hsa_M00912 NAD biosynthesis, tryptophan => quinolinate => NAD
Display drug-target relation   disease type
N01685    Lys+NADPH−AASS⇉ALDH7A1⇉AADAT→2-OA
    Hyperlysinemia/Saccharopinuria Lys↗ AASS*
    PDE     ALDH7A1*
N01724    NAD+−(NADK2,NADK)⇉NADP+
    DECR   NADK2*
N01686    2-OA+Lipoyl-E2−DHTKD1⇉DLST→Glutaryl-CoA+Dihyd..
    AAKAD   DHTKD1*
N01687    Glutaryl-CoA−GCDH→Crotonoyl-CoA
    GA1 Glutaryl-CoA↗ GCDH*
N01723    Trp−(TDO2,IDO1/2)⇉AFMID→Kyn−KMO⇉KYNU⇉HAAO⇉QPRT⇉NMNAT⇉NADSYN1→NAD+
    Hydroxykynureninuria/VCRL2           KYNU*
    VCRL1             HAAO*
    VCRL3                   NADSYN1*

Disease nameDisease category
Hyperlysinemia/SaccharopinuriaH00188HyperlysinemiaInherited metabolic disorder
H01242SaccharopinuriaInherited metabolic disorder
PDEH01247Pyridoxine-dependent epilepsyNervous system disease
DECRH019292,4-Dienoyl-CoA reductase deficiencyInherited metabolic disorder, Mitochondrial disease
AAKADH02644Alpha-aminoadipic and alpha-ketoadipic aciduriaInherited metabolic disorder
GA1H00178Glutaric acidemiaInherited metabolic disorder
Hydroxykynureninuria/VCRL2H01583HydroxykynureninuriaInherited metabolic disorder
H02087Vertebral, cardiac, renal, and limb defects syndromeInherited metabolic disorder
VCRL1H02087Vertebral, cardiac, renal, and limb defects syndromeInherited metabolic disorder
VCRL3H02087Vertebral, cardiac, renal, and limb defects syndromeInherited metabolic disorder