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ENTRY	nt06539
Name	Cytoskeleton in muscle cells
Category	Pathway view; Cellular process
Pathway	hsa04820 Cytoskeleton in muscle cells
Disease	H00294 Dilated cardiomyopathy H00292 Hypertrophic cardiomyopathy H01219 Restrictive cardiomyopathy H00293 Arrhythmogenic right ventricular cardiomyopathy H01810 Congenital myopathy H00562 Dystrophinopathies H00593 Limb-girdle muscular dystrophy
Display	drug-target relation   disease type

N01814    (COL1/3/5/9/11A+DC.. = (COL6A+THBS) = (COL4A+FBLN1/2+HSP.. = Costamere     OI1/2/3/4/OST/ICH/EDSARTH1/OIEDS1 COL1A1*     OI2/3/4/OST/EDSCV/EDSARTH2/OIEDS2 COL1A2*     PMGEDSV/EDSVASC COL3A1*     EDSCL1/FMDMF COL5A1*     EDSCL2 COL5A2*     EDM6/STL4 COL9A1*     EDM2/STL5 COL9A2*     EDM3/STL6/IDD COL9A3*     DFNA37/STL2/FBCG1/MRSHS/IDD COL11A1*     DFNA13/DFNB53/STL3/OSMED/FBCG2 COL11A2*     CSCD DCN*     WGVRP VCAN*     SVAS/ADCL1 ELN*     UCMD1A/BTHLM1A     COL6A1*     UCMD1B/BTHLM1B     COL6A2*     UCMD1/BTHLM1/DYT27     COL6A3*     IDD     THBS2*     EDM1/PSACH/CTS2     COMP*     HANAC/BSVD1         COL4A1*     PADMAL         COL4A1* ↗     BSVD2         COL4A2*     ATS3/BFH2         COL4A3*     ATS2/BFH1         COL4A4*     ATS1         COL4A5*     DFNX6         COL4A6*     SPD2         FBLN1*     DDSH/SJS1         HSPG2*     GFND/SMDCF         FN1*     CMS8         AGRN*     SEMDX/MRLS         BGN*     MFS/WMS2/SSS/GPHYSD2/ACMICD         FBN1*     DA9         FBN2* N01758    (DSC2,DSG2) = (PKP2,JUP+DSP) = (DES,VIM) = Z-disc     ARVD11 DSC2*     ARVD10/CMD1BB DSG2*     ARVD9     PKP2*     ARVD12/NXD     JUP*     ARVD8/PPKS2/EBLA/DCWHK     DSP*     CMD1I/MFM1/SCPNK         DES* N01815    ECM = LAMA = (ITGA+ITGB) = TLN = VCL = ACTN = ACTB/G = Z-disc     JEB7         ITGA3*     JEB5         ITGB4*     JEB6         ITGA6*     CMD         ITGA7*     CMH15/CMD1W                 VCL*     CMH23/CMD1AA/MPD6/CMYP8                     ACTN2*     BNS                         ACTB*     VSCM1/MMIHS5                         ACTG2*     BRWS1/DDS1                         ACTB* ↗     BRWS2/DFNA20/26                         ACTG1* ↗ N01816    ECM = LAMA = (DAG1+SGC+SSPN) = (DMD+SNTA/B+DTNA+F.. = DES = Z-disc     LGMDR23/MDC1A     LAMA2*     LGMDR16/MDDG         DAG1*     LGMDR3         SGCA*     LGMDR4         SGCB*     LGMDR6/CMD1L         SGCD*     DYT11         SGCE*     LGMDR5         SGCG*     DMD/BMD/CMD3B             DMD*     LVNC1             DTNA*     CMH26/MPD4/MFM5/RCM5             FLNC*       D1  |             N01817    Actin_thin_filamen.. = (MYH+MYL+MYBP) = TTN = (MYOM,TCAP) = M-band,Z-disc     CMYP6     MYH2*     DA2A/B3/CPSFS     MYH3*     CMH14/CMD1EE/ASD3/SSS3     MYH6*     CMH1/CMD1S/MPD1/CMYP7     MYH7*     DA7     MYH8*     AAT4/MMIHS2/VSCM2     MYH11*     CMYP14     MYL1*     CMH10/MFM12     MYL2*     CMH8     MYL3*     ATFB18     MYL4*     MMIHS4     MYL9*     DA1C     MYL11*     DA1B/LCCS4/CMYP16     MYBPC1*     CMH4/CMD1MM     MYBPC3*     CMD1G/LGMDR10/MFM9/CMYP5         TTN*     CMH9         TTN* ↗     LGMDR7             TCAP*     CMH25             TCAP* ↗                   D1  |     N01818    Ca2+ → (TNNC+TNNI+TNNT) ⊣ TPM ⊣ ACTA/C = MYH = Myosin_thick_filam..     CMD1Z     TNNC1*     CMYP15     TNNC2*     CMD1FF/CMD2A/RCM1     TNNI3*     NEM5     TNNT1*     CMD1D/RCM3     TNNT2*     CMH13     TNNC1* ↗     DA2B1     TNNI2* ↗     CMH7     TNNI3* ↗     RCM3/CMH2     TNNT2* ↗     DA2B2     TNNT3* ↗     CMD1Y         TPM1*     CMYP4         TPM3*     CMH3         TPM1* ↗     CMYP4A         TPM3* ↗     CMYP2/SHPM             ACTA1*     CMD1R/ASD5             ACTC1*     CMH11             ACTC1* ↗ N01819    (TMOD,LMOD) = (ACTA/C+TPM+(NEB,N.. = CAPZ = Z-disc     MMIHS3 LMOD1*     CMD2G LMOD2*     NEM2/AMC6     NEB* N01820    Actin_thin_filamen.. = ACTA/C = (MYOT+ACTN2/3) = (MLP,MYOZ,MYPN,MAR..     MFM3         MYOT*     CMD1M/CMH12             CSRP3*     CMH16             MYOZ2*     CMH22/CMYP24/CMD1KK/RCM4             MYPN*     CMH28             FHOD3* N01821    Myosin_thick_filam.. = MYOM = (OBSCN,ENO,MURF,CA..     SPG76         CAPN1*     LGMDD4/R1         CAPN3*     NEM7         CFL2* N01822    DES = PLEC = (SYNE3,SYNE1,SYNE2.. = (SUN,TMEM43,EMD,LB.. = (LMNA+LMNB)     EBS5/LGMDR17     PLEC*     EDMD5         SYNE2*     ARVD5/EDMD7/AUNA3             TMEM43*     EDMD1             EMD*     PHA/REYNOLDS/SKPHA             LBR*     EDMD2/3/CMD1A/FPLD2/CMT2B1/CMD/HGPS/RSDM2/MADA/HHS-S                 LMNA*     MCPH27/APLD/EPM9                 LMNB2*     MCPH26                 LMNB1*     ADLD                 LMNB1* ↗

		Disease name	Disease category
OI1/2/3/4/OST/ICH/EDSARTH1/OIEDS1	H00506	Osteogenesis imperfecta	Congenital malformation
	H01593	Osteoporosis	Musculoskeletal disease
	H00613	Infantile cortical hyperostosis	Musculoskeletal disease
	H02243	Ehlers-Danlos syndrome arthrochalasia type	Congenital malformation
	H02724	Combined osteogenesis imperfecta and Ehlers-Danlos syndrome	Congenital malformation
OI2/3/4/OST/EDSCV/EDSARTH2/OIEDS2	H00506	Osteogenesis imperfecta	Congenital malformation
	H01593	Osteoporosis	Musculoskeletal disease
	H02241	Ehlers-Danlos syndrome cardiac valvular type	Congenital malformation
	H02243	Ehlers-Danlos syndrome arthrochalasia type	Congenital malformation
	H02724	Combined osteogenesis imperfecta and Ehlers-Danlos syndrome	Congenital malformation
PMGEDSV/EDSVASC	H00271	Polymicrogyria	Congenital malformation
	H02242	Ehlers-Danlos syndrome vascular type	Congenital malformation
EDSCL1/FMDMF	H00802	Ehlers-Danlos syndrome	Congenital malformation
	H02719	Multifocal fibromuscular dysplasia	Cardiovascular disease
EDSCL2	H00802	Ehlers-Danlos syndrome	Congenital malformation
EDM6/STL4	H00476	Multiple epiphyseal dysplasia	Congenital malformation
	H02072	Stickler syndrome	Congenital malformation
EDM2/STL5	H00476	Multiple epiphyseal dysplasia	Congenital malformation
	H02072	Stickler syndrome	Congenital malformation
EDM3/STL6/IDD	H00476	Multiple epiphyseal dysplasia	Congenital malformation
	H02072	Stickler syndrome	Congenital malformation
	H02539	Intervertebral disc disease	Musculoskeletal disease
DFNA37/STL2/FBCG1/MRSHS/IDD	H00604	Deafness, autosomal dominant	Nervous system disease
	H00805	Vitreoretinal degeneration	Nervous system disease
	H02080	Fibrochondrogenesis	Congenital malformation
	H02081	Marshall syndrome	Congenital malformation
	H02539	Intervertebral disc disease	Musculoskeletal disease
DFNA13/DFNB53/STL3/OSMED/FBCG2	H00604	Deafness, autosomal dominant	Nervous system disease
	H00605	Deafness, autosomal recessive	Nervous system disease
	H02072	Stickler syndrome	Congenital malformation
	H02079	Oto-spondylo-megaepiphyseal dysplasia	Congenital malformation
	H02080	Fibrochondrogenesis	Congenital malformation
CSCD	H00958	Congenital stromal corneal dystrophy	Nervous system disease
WGVRP	H00805	Vitreoretinal degeneration	Nervous system disease
SVAS/ADCL1	H00553	Congenital supravalvular aortic stenosis	Congenital malformation
	H00557	Cutis laxa	Congenital malformation
UCMD1A/BTHLM1A	H01341	Collagen VI myopathy	Nervous system disease
UCMD1B/BTHLM1B	H01341	Collagen VI myopathy	Nervous system disease
UCMD1/BTHLM1/DYT27	H01341	Collagen VI myopathy	Nervous system disease
	H00831	Primary dystonia	Nervous system disease
IDD	H02539	Intervertebral disc disease	Musculoskeletal disease
EDM1/PSACH/CTS2	H00476	Multiple epiphyseal dysplasia	Congenital malformation
	H00477	Pseudoachondroplasia	Congenital malformation
	H00798	Familial carpal tunnel syndrome	Nervous system disease
HANAC/BSVD1	H00579	Hereditary angiopathy with nephropathy, aneurysms, and muscle cramps (HANAC)	Congenital malformation
	H00877	Brain small vessel disease	Cardiovascular disease
PADMAL	H02718	Autosomal dominant pontine microangiopathy and leukoencephalopathy	Congenital malformation
BSVD2	H00877	Brain small vessel disease	Cardiovascular disease
ATS3/BFH2	H00581	Alport syndrome	Congenital malformation
	H00582	Benign familial hematuria	Urinary system disease
ATS2/BFH1	H00581	Alport syndrome	Congenital malformation
	H00582	Benign familial hematuria	Urinary system disease
ATS1	H00581	Alport syndrome	Congenital malformation
DFNX6	H01209	Deafness, X-linked	Nervous system disease
SPD2	H00459	Synpolydactyly	Congenital malformation
DDSH/SJS1	H00493	Heparan sulfate proteoglycan gene defects	Congenital malformation
GFND/SMDCF	H01260	Glomerulopathy with fibronectin deposits	Urinary system disease
	H02185	Spondylometaphyseal dysplasia	Congenital malformation
CMS8	H00770	Congenital myasthenic syndrome	Nervous system disease
SEMDX/MRLS	H02187	Spondyloepimetaphyseal dysplasia	Congenital malformation
	H02720	Meester-Loeys syndrome	Cardiovascular disease
MFS/WMS2/SSS/GPHYSD2/ACMICD	H00653	Marfan syndrome	Congenital malformation
	H00673	Weill-Marchesani syndrome	Congenital malformation
	H01173	Stiff skin syndrome	Skin disease
	H00900	Geleophysic dysplasia	Congenital malformation
	H02228	Acromicric dysplasia	Congenital malformation
DA9	H00811	Distal arthrogryposis	Congenital malformation
ARVD11	H00293	Arrhythmogenic right ventricular cardiomyopathy	Cardiovascular disease
ARVD10/CMD1BB	H00293	Arrhythmogenic right ventricular cardiomyopathy	Cardiovascular disease
	H00294	Dilated cardiomyopathy	Cardiovascular disease
ARVD9	H00293	Arrhythmogenic right ventricular cardiomyopathy	Cardiovascular disease
ARVD12/NXD	H00293	Arrhythmogenic right ventricular cardiomyopathy	Cardiovascular disease
	H00669	Naxos disease	Congenital malformation
ARVD8/PPKS2/EBLA/DCWHK	H00293	Arrhythmogenic right ventricular cardiomyopathy	Cardiovascular disease
	H00717	Striate palmoplantar keratoderma	Congenital malformation
	H01737	Epidermolysis bullosa	Congenital malformation
	H02094	Carvajal syndrome	Congenital malformation
CMD1I/MFM1/SCPNK	H00294	Dilated cardiomyopathy	Cardiovascular disease
	H00595	Myofibrillar myopathies	Nervous system disease
	H00656	Scapuloperoneal myopathy	Nervous system disease
JEB7	H00586	Epidermolysis bullosa, junctional	Congenital malformation
JEB5	H00586	Epidermolysis bullosa, junctional	Congenital malformation
JEB6	H00586	Epidermolysis bullosa, junctional	Congenital malformation
CMD	H00590	Congenital muscular dystrophies (CMD/MDC)	Nervous system disease
CMH15/CMD1W	H00292	Hypertrophic cardiomyopathy	Cardiovascular disease
	H00294	Dilated cardiomyopathy	Cardiovascular disease
CMH23/CMD1AA/MPD6/CMYP8	H00292	Hypertrophic cardiomyopathy	Cardiovascular disease
	H00294	Dilated cardiomyopathy	Cardiovascular disease
	H00594	Distal myopathy	Nervous system disease
	H01810	Congenital myopathy	Nervous system disease
BNS	H02716	Becker nevus syndrome	Congenital malformation
VSCM1/MMIHS5	H02553	Visceral myopathy	Congenital malformation
	H01869	Megacystis microcolon intestinal hypoperistalsis syndrome	Congenital malformation
BRWS1/DDS1	H02023	Baraitser-Winter syndrome	Congenital malformation
	H01255	Juvenile-onset dystonia	Congenital malformation
BRWS2/DFNA20/26	H02023	Baraitser-Winter syndrome	Congenital malformation
	H00604	Deafness, autosomal dominant	Nervous system disease
LGMDR23/MDC1A	H00593	Limb-girdle muscular dystrophy	Nervous system disease
	H01958	Merosin-deficient congenital muscular dystrophy	Nervous system disease
LGMDR16/MDDG	H00593	Limb-girdle muscular dystrophy	Nervous system disease
	H02307	Muscular dystrophy-dystroglycanopathy	Inherited metabolic disorder
LGMDR3	H00593	Limb-girdle muscular dystrophy	Nervous system disease
LGMDR4	H00593	Limb-girdle muscular dystrophy	Nervous system disease
LGMDR6/CMD1L	H00593	Limb-girdle muscular dystrophy	Nervous system disease
	H00294	Dilated cardiomyopathy	Cardiovascular disease
DYT11	H00831	Primary dystonia	Nervous system disease
LGMDR5	H00593	Limb-girdle muscular dystrophy	Nervous system disease
DMD/BMD/CMD3B	H00562	Dystrophinopathies	Nervous system disease
LVNC1	H01216	Left ventricular noncompaction	Cardiovascular disease
CMH26/MPD4/MFM5/RCM5	H00292	Hypertrophic cardiomyopathy	Cardiovascular disease
	H00594	Distal myopathy	Nervous system disease
	H00595	Myofibrillar myopathies	Nervous system disease
	H01219	Restrictive cardiomyopathy	Cardiovascular disease
CMYP6	H01810	Congenital myopathy	Nervous system disease
DA2A/B3/CPSFS	H00811	Distal arthrogryposis	Congenital malformation
	H02717	Contractures, pterygia, and spondylocarpotarsal fusion syndrome	Congenital malformation
CMH14/CMD1EE/ASD3/SSS3	H00292	Hypertrophic cardiomyopathy	Cardiovascular disease
	H00294	Dilated cardiomyopathy	Cardiovascular disease
	H00546	Atrial septal defect	Congenital malformation
	H00729	Sick sinus syndrome	Cardiovascular disease
CMH1/CMD1S/MPD1/CMYP7	H00292	Hypertrophic cardiomyopathy	Cardiovascular disease
	H00294	Dilated cardiomyopathy	Cardiovascular disease
	H00594	Distal myopathy	Nervous system disease
	H01810	Congenital myopathy	Nervous system disease
DA7	H00811	Distal arthrogryposis	Congenital malformation
AAT4/MMIHS2/VSCM2	H00801	Familial thoracic aortic aneurysm and dissection	Cardiovascular disease
	H01869	Megacystis microcolon intestinal hypoperistalsis syndrome	Congenital malformation
	H02553	Visceral myopathy	Congenital malformation
CMYP14	H01810	Congenital myopathy	Nervous system disease
CMH10/MFM12	H00292	Hypertrophic cardiomyopathy	Cardiovascular disease
	H00595	Myofibrillar myopathies	Nervous system disease
CMH8	H00292	Hypertrophic cardiomyopathy	Cardiovascular disease
ATFB18	H00731	Atrial fibrillation	Cardiovascular disease
MMIHS4	H01869	Megacystis microcolon intestinal hypoperistalsis syndrome	Congenital malformation
DA1C	H00811	Distal arthrogryposis	Congenital malformation
DA1B/LCCS4/CMYP16	H00811	Distal arthrogryposis	Congenital malformation
	H00865	Lethal congenital contractural syndrome	Congenital malformation
	H01810	Congenital myopathy	Nervous system disease
CMH4/CMD1MM	H00292	Hypertrophic cardiomyopathy	Cardiovascular disease
	H00294	Dilated cardiomyopathy	Cardiovascular disease
CMD1G/LGMDR10/MFM9/CMYP5	H00294	Dilated cardiomyopathy	Cardiovascular disease
	H00593	Limb-girdle muscular dystrophy	Nervous system disease
	H00595	Myofibrillar myopathies	Nervous system disease
	H01810	Congenital myopathy	Nervous system disease
CMH9	H00292	Hypertrophic cardiomyopathy	Cardiovascular disease
LGMDR7	H00593	Limb-girdle muscular dystrophy	Nervous system disease
CMH25	H00292	Hypertrophic cardiomyopathy	Cardiovascular disease
CMD1Z	H00294	Dilated cardiomyopathy	Cardiovascular disease
CMYP15	H01810	Congenital myopathy	Nervous system disease
CMD1FF/CMD2A/RCM1	H00294	Dilated cardiomyopathy	Cardiovascular disease
	H01219	Restrictive cardiomyopathy	Cardiovascular disease
NEM5	H00698	Nemaline myopathy	Nervous system disease
CMD1D/RCM3	H00294	Dilated cardiomyopathy	Cardiovascular disease
	H01219	Restrictive cardiomyopathy	Cardiovascular disease
CMH13	H00292	Hypertrophic cardiomyopathy	Cardiovascular disease
DA2B1	H00811	Distal arthrogryposis	Congenital malformation
CMH7	H00292	Hypertrophic cardiomyopathy	Cardiovascular disease
RCM3/CMH2	H01219	Restrictive cardiomyopathy	Cardiovascular disease
	H00292	Hypertrophic cardiomyopathy	Cardiovascular disease
DA2B2	H00811	Distal arthrogryposis	Congenital malformation
CMD1Y	H00294	Dilated cardiomyopathy	Cardiovascular disease
CMYP4	H01810	Congenital myopathy	Nervous system disease
CMH3	H00292	Hypertrophic cardiomyopathy	Cardiovascular disease
CMYP4A	H01810	Congenital myopathy	Nervous system disease
CMYP2/SHPM	H01810	Congenital myopathy	Nervous system disease
	H02721	Scapulohumeroperoneal myopathy	Nervous system disease
CMD1R/ASD5	H00294	Dilated cardiomyopathy	Cardiovascular disease
	H00546	Atrial septal defect	Congenital malformation
CMH11	H00292	Hypertrophic cardiomyopathy	Cardiovascular disease
MMIHS3	H01869	Megacystis microcolon intestinal hypoperistalsis syndrome	Congenital malformation
CMD2G	H00294	Dilated cardiomyopathy	Cardiovascular disease
NEM2/AMC6	H00698	Nemaline myopathy	Nervous system disease
	H02299	Arthrogryposis multiplex congenita	Congenital malformation
MFM3	H00595	Myofibrillar myopathies	Nervous system disease
CMD1M/CMH12	H00294	Dilated cardiomyopathy	Cardiovascular disease
	H00292	Hypertrophic cardiomyopathy	Cardiovascular disease
CMH16	H00292	Hypertrophic cardiomyopathy	Cardiovascular disease
CMH22/CMYP24/CMD1KK/RCM4	H00292	Hypertrophic cardiomyopathy	Cardiovascular disease
	H01810	Congenital myopathy	Nervous system disease
	H00294	Dilated cardiomyopathy	Cardiovascular disease
	H01219	Restrictive cardiomyopathy	Cardiovascular disease
CMH28	H00292	Hypertrophic cardiomyopathy	Cardiovascular disease
SPG76	H00266	Hereditary spastic paraplegia	Nervous system disease
LGMDD4/R1	H00593	Limb-girdle muscular dystrophy	Nervous system disease
NEM7	H00698	Nemaline myopathy	Nervous system disease
EBS5/LGMDR17	H00584	Epidermolysis bullosa simplex	Congenital malformation
	H00593	Limb-girdle muscular dystrophy	Nervous system disease
EDMD5	H00563	Emery-Dreifuss muscular dystrophy	Nervous system disease
ARVD5/EDMD7/AUNA3	H00293	Arrhythmogenic right ventricular cardiomyopathy	Cardiovascular disease
	H00563	Emery-Dreifuss muscular dystrophy	Nervous system disease
	H02339	Auditory neuropathy	Nervous system disease
EDMD1	H00563	Emery-Dreifuss muscular dystrophy	Nervous system disease
PHA/REYNOLDS/SKPHA	H00234	Pelger-Huet anomaly	Hematologic disease
	H01133	Reynolds syndrome	Immune system disease
	H02732	Rhizomelic skeletal dysplasia with or without Pelger-Huet anomaly	Congenital malformation
EDMD2/3/CMD1A/FPLD2/CMT2B1/CMD/HGPS/RSDM2/MADA/HHS-S	H00563	Emery-Dreifuss muscular dystrophy	Nervous system disease
	H00294	Dilated cardiomyopathy	Cardiovascular disease
	H00420	Familial partial lipodystrophy	Inherited metabolic disorder
	H00264	Charcot-Marie-Tooth disease	Neurodegenerative disease
	H00590	Congenital muscular dystrophies (CMD/MDC)	Nervous system disease
	H00601	Hutchinson-Gilford progeria syndrome	Inherited metabolic disorder
	H00663	Restrictive dermopathy	Congenital malformation
	H00665	Mandibuloacral dysplasia	Congenital malformation
	H02725	Heart-hand syndrome	Congenital malformation
MCPH27/APLD/EPM9	H00269	Primary microcephaly	Congenital malformation
	H00420	Familial partial lipodystrophy	Inherited metabolic disorder
	H00810	Progressive myoclonic epilepsy	Nervous system disease
MCPH26	H00269	Primary microcephaly	Congenital malformation
ADLD	H01230	Adult-onset autosomal dominant leukodystrophy	Nervous system disease

		Drug name
D1	D12902	Sevasemten (USAN/INN)