Entry
Name
lactate dehydrogenase (NAD+,ferredoxin);
electron bifurcating LDH/Etf complex
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
lactate:NAD+,ferredoxin oxidoreductase
Reaction(IUBMB)
lactate + 2 NAD+ + 2 reduced ferredoxin [iron-sulfur] cluster = pyruvate + 2 NADH + 2 oxidized ferredoxin [iron-sulfur] cluster [RN:
R11676 ]
Reaction(KEGG)
Substrate
lactate [CPD:
C01432 ];
NAD+ [CPD:
C00003 ];
reduced ferredoxin [iron-sulfur] cluster [CPD:
C00138 ]
Product
pyruvate [CPD:
C00022 ];
NADH [CPD:
C00004 ];
oxidized ferredoxin [iron-sulfur] cluster [CPD:
C00139 ]
Comment
The enzyme, isolated from the bacterium Acetobacterium woodii, uses flavin-based electron confurcation to drive endergonic lactate oxidation with NAD+ as oxidant at the expense of simultaneous exergonic electron flow from reduced ferredoxin to NAD+.
History
EC 1.1.1.436 created 2015 as EC 1.3.1.110, transferred 2022 to EC 1.1.1.436
Pathway
Orthology
K26113 lactate dehydrogenase (NAD+,ferredoxin) subunit LctD
Genes
CBEI : LF65_00348 LF65_02571
CSR : Cspa_c03510(glcD1) Cspa_c19410(glcD2) Cspa_c41430
CPAS : Clopa_3349 Clopa_3664
CPAT : CLPA_c14970(glcD1) CLPA_c29580(glcD2)
CPAE : CPAST_c14970(glcD1) CPAST_c29580(glcD2)
CSB : CLSA_c03500(glcD1) CLSA_c19070(glcD2)
CACE : CACET_c37490(glcD2)
CCK : Ccar_02285 Ccar_11415
CBUT : ATN24_03035 ATN24_08895 ATN24_11095
CTYK : CTK_C13670 CTK_C15710 CTK_C26210
CEU : A7L45_05755 A7L45_05810
CDRK : B9W14_07280 B9W14_15575
CDY : F3K33_01575 F3K33_14625
CCAA : KQH81_05590 KQH81_16525
CRW : CROST_032090 CROST_034820
CFB : CLFE_013700 CLFE_032010
CAUN : CLAUR_041110 CLAUR_044190
CGEL : psyc5s11_17870 psyc5s11_17920 psyc5s11_17980(glcD_1) psyc5s11_21450(glcD_2)
CINT : HZF06_09775 HZF06_19080
CAPR : EQM14_05780 EQM14_11115
LXA : OW255_00695 OW255_07590 OW255_07625 OW255_10930
BPRL : CL2_13250 CL2_23160 CL2_23560
ARF : AR1Y2_0863 AR1Y2_1968 AR1Y2_1979
ACAC : EYQ97_07920 EYQ97_07955 EYQ97_12845
ACHT : bsdcttw_20890(glcD)
» show all
Taxonomy
Reference
Authors
Weghoff MC, Bertsch J, Muller V
Title
A novel mode of lactate metabolism in strictly anaerobic bacteria.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 1.1.1.436
LinkDB
All DBs