KEGG   ENZYME: 1.2.1.83
Entry
EC 1.2.1.83                 Enzyme                                 
Name
3-succinoylsemialdehyde-pyridine dehydrogenase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
Sysname
4-oxo-4-(pyridin-3-yl)butanal:NADP+ oxidoreductase
Reaction(IUBMB)
4-oxo-4-(pyridin-3-yl)butanal + NADP+ + H2O = 4-oxo-4-(pyridin-3-yl)butanoate + NADPH + H+ [RN:R10105]
Reaction(KEGG)
R10105
Substrate
4-oxo-4-(pyridin-3-yl)butanal [CPD:C19567];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
4-oxo-4-(pyridin-3-yl)butanoate [CPD:C19569];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme has been characterized from the soil bacterium Pseudomonas sp. HZN6. It participates in the nicotine degradation pathway.
History
EC 1.2.1.83 created 2012
Pathway
ec00760  Nicotinate and nicotinamide metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K19700  3-succinoylsemialdehyde-pyridine dehydrogenase
Genes
PPTPPS_4079
PMONX969_19985
PMOTX970_19620
PMEDE3Z27_20795
PVKEPZ47_21945
PSJYAA098_04090
ALCAASALC70_03936(ald_1)
GSOPH603_02990
Reference
1  [PMID:22267672]
  Authors
Qiu J, Ma Y, Wen Y, Chen L, Wu L, Liu W
  Title
Functional identification of two novel genes from Pseudomonas sp. strain HZN6 involved in the catabolism of nicotine.
  Journal
Appl Environ Microbiol 78:2154-60 (2012)
DOI:10.1128/AEM.07025-11
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.83
IUBMB Enzyme Nomenclature: 1.2.1.83
ExPASy - ENZYME nomenclature database: 1.2.1.83
BRENDA, the Enzyme Database: 1.2.1.83
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