KEGG   ENZYME: 2.4.2.59
Entry
EC 2.4.2.59                 Enzyme                                 
Name
sulfide-dependent adenosine diphosphate thiazole synthase;
Thi4 (ambiguous)
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
Sysname
NAD+:glycine ADP-D-ribosyltransferase (sulfide-adding)
Reaction(IUBMB)
NAD+ + glycine + sulfide = nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 3 H2O [RN:R12026]
Reaction(KEGG)
R12026
Substrate
NAD+ [CPD:C00003];
glycine [CPD:C00037];
sulfide [CPD:C00283]
Product
nicotinamide [CPD:C00153];
ADP-5-ethyl-4-methylthiazole-2-carboxylate [CPD:C20784];
H2O [CPD:C00001]
Comment
This iron dependent enzyme, found in most archaea, is involved in the biosynthesis of thiamine phosphate. The homologous enzyme from plants and fungi (EC 2.4.2.60, cysteine-dependent adenosine diphosphate thiazole synthase) uses an intrinsic cysteine as sulfur donor and, unlike the archaeal enzyme, is a single turn-over enzyme.
History
EC 2.4.2.59 created 2018
Pathway
ec00730  Thiamine metabolism
ec01100  Metabolic pathways
Orthology
K22699  sulfide-dependent adenosine diphosphate thiazole synthase
Genes
BBAR: RHAL1_03078
CAUL: KCG34_24290
MALU: KU6B_16750
HMR: Hipma_0421
DAV: DESACE_08810
DMA: DMR_31420
DCB: C3Y92_06440
DGG: DGI_1133
DMS: E8L03_06730
DAF: Desaf_0994
DSX: GD604_13095
DSD: GD606_19515
DLM: DPPLL_35930
DOL: Dole_2426
DAL: Dalk_2394
DOV: DSCO28_45120
DLI: dnl_00920(thiG)
DMM: dnm_073520(thiG)
DAO: Desac_0998
DAX: FDQ92_03460
DBR: Deba_1981
DMP: FAK_22910
TID: Thein_1804
TOP: TOPB45_0915
TCM: HL41_01820
THET: F1847_03705
CTHI: THC_0653
TAV: G4V39_01630
TMAI: FVE67_08730
DHR: LGS26_09060
CLJ: CLJU_c30580
CSQ: CSCA_1812
CDRK: B9W14_10240
CFER: D4Z93_11890
CLOS: DMR38_15480
DKU: Desku_1659
DAU: Daud_0859
TJR: TherJR_1442
ADG: Adeg_0421 Adeg_1609
GEK: kuro4_04070
MBX: BCGT_0584
MPHL: MPHLCCUG_05062(ksdD_3)
SLK: SLUN_34370
TNR: Thena_0778
TACI: TDSAC_0747
HBS: IPV69_04150
VAI: BU251_06310 BU251_06360
TAI: Taci_1358
TLI: Tlie_1851
AMO: Anamo_0225
BCEL: BcellWH2_01838
BIS: DXK01_001245
PSOE: CE91St14_02970
PDI: BDI_1609
PARC: CI960_06610
PMER: INE87_00229
PGOL: K6V26_06880
PJO: LK449_05640
PFAI: NXY11_05335
PMZ: HMPREF0659_A5800
PIT: PIN17_A0608
PNI: J5A59_03980
PHER: prwr041_11060
PSCJ: J4856_09105
PBIV: QP022_05995
RBC: BN938_1539
TTZ: FHG85_07515
MBAS: ALGA_3764
PAA: Paes_1007
PROC: Ptc2401_01068
PRS: B9H02_06355
PROS: CHL67_06345
TAM: Theam_0077
DTE: Dester_1473
TTK: TST_0727(thi1)
TMA: TM0787
TMM: Tmari_0788
TMI: THEMA_00715
TMW: THMA_0806
TMQ: THMB_0806
TMX: THMC_0806
TPT: Tpet_0142
TNP: Tnap_0143
TRQ: TRQ2_0140
TNA: CTN_1791
THQ: T2812B_00715
THZ: CELL2_00740
THR: TRQ7_00715
TLE: Tlet_1750
TTA: Theth_1374
TME: Tmel_1590
TAF: THA_1798
THP: BG95_08660
THER: Y592_08765
FNO: Fnod_1422
FPE: Ferpe_0640
FIA: NA23_03490
FRR: IB67_05365
NDE: NIDE1062
NMV: NITMOv2_0947
NIO: NITINOP_1921
NJA: NSJP_2079
NKF: Nkreftii_003088
NIF: W02_33410
NTI: DNFV4_01351
NALL: PP769_00420
NNEO: PQG83_11585
FSH: Q2T83_00155
MJA: MJ_0601
MFE: Mefer_1385
MVU: Metvu_1585
MFS: MFS40622_1580
MIF: Metin_1281
MJH: JH146_0825
MESG: MLAUSG7_1377(thi)
MESA: MLASG1_0803(thi)
MIG: Metig_0735 Metig_1112
MMP: MMP1352
MMQ: MmarC5_0226
MMX: MmarC6_1321
MMZ: MmarC7_0597
MMAK: MMKA1_15750
MMAO: MMOS7_14560
MMAD: MMJJ_14870
MAE: Maeo_0798
MVN: Mevan_0663
MVO: Mvol_0738
MOK: Metok_0500
METF: CFE53_00030
MTH: MTH_1620
MMG: MTBMA_c02060
MWO: MWSIV6_0166(Thi4)
MTEE: MTTB_13720
METC: MTCT_1479
METE: tca_01569
METZ: METMT2_1460
METK: FVF72_03520
MTHM: FZP57_00720
METJ: FZP68_05735
MEB: Abm4_1461
MEL: Metbo_0536 Metbo_1265
MEW: MSWAN_0974 MSWAN_1853
METH: MBMB1_1137 MBMB1_1486
MFC: BRM9_0713 BRM9_1347
MFI: DSM1535_0665 DSM1535_2031
MCUB: MCBB_1020 MCBB_1725
MSUB: BK009_06380
METN: BK008_01970
METT: CIT01_06780
METO: CIT02_02510 CIT02_10600
MEME: HYG87_01485 HYG87_07505
MFEG: GCM10025860_28950
MFV: Mfer_0175
MKA: MK0430
AFU: AF_0702
AFG: AFULGI_00007840
APO: Arcpr_1423
AVE: Arcve_1405
AST: Asulf_00980
FPL: Ferp_0628
GAC: GACE_0145
GAH: GAH_01007
PFU: PF1530
PFI: PFC_06880
PHO: PH1357(PH1357)
PAB: PAB0536(thi1)
PYN: PNA2_1583 PNA2_1941
PYA: PYCH_06240 PYCH_08650
PYS: Py04_1231
PYC: TQ32_10505
TKO: TK0434
TGA: TGAM_1270
THE: GQS_02015
THM: CL1_0036
TLT: OCC_06556
THS: TES1_1982
TNU: BD01_0513
TEU: TEU_09505
TGY: X802_10050
THV: ADU37_CDS17350 ADU37_CDS22280
TCH: CHITON_1554
TPEP: A0127_02260
TPIE: A7C91_09070
TCE: A3L02_01985
TTD: A3L14_05500
TPRF: A3L09_06395
TPAF: A3L08_06895
THY: A3L12_03095
TIC: FH039_06460
TCQ: TIRI35C_0994(thi)
THEM: FPV09_02920
PPAC: PAP_08770
MBA: Mbar_A2100
MBY: MSBRM_2409
MBW: MSBRW_2643
MBAR: MSBR2_2375
MBAK: MSBR3_2431
MAC: MA_2851
MMA: MM_0222
MMAZ: MmTuc01_0227
MMJ: MSMAS_1078
MMAC: MSMAC_2441
MVC: MSVAZ_1117
MEK: MSKOL_1072
MLS: MSLAZ_1169
METM: MSMTP_1119
MEF: MSWH1_1762
MEQ: MSWHS_1554
MSJ: MSSAC_2840
MSZ: MSSIH_2497
MSW: MSSIT_2540
MTHR: MSTHT_0054
MTHE: MSTHC_0676
MHOR: MSHOH_1299
MFZ: AOB57_002245
MBU: Mbur_2109
MMET: MCMEM_0306 MCMEM_0840
MELO: J7W08_02430 J7W08_11625
MMH: Mmah_0298
MHAZ: BHR79_02030
MPOT: BKM01_06375
MEV: Metev_0188
MZH: Mzhil_1372
MZI: HWN40_08730
MMAV: RE476_01435
MSEB: RE474_11125
MTP: Mthe_1121
MCJ: MCON_3229
MHI: Mhar_2378
MHU: Mhun_1935
MRTJ: KHC33_14740
MLA: Mlab_0277
MEM: Memar_2251
MBG: BN140_1460(thi1)
MEMA: MMAB1_1869
MCHK: MchiMG62_25690
MSUM: OH143_05540
MRC: R6Y96_03785
MPI: Mpet_0116
MEND: L6E24_07545
MEFW: F1737_10475
MAQE: RJ40_07140
MFK: E2N92_07295
MOU: OU421_07750
MESB: L1S32_11135
MANQ: L1994_01520
MFO: Metfor_0238
MEZ: Mtc_1604(thi4-1) Mtc_2398(thi4-2)
HAL: VNG_2604G(thi1)
HSL: OE_4651F(thi4)
HANR: LJ422_10530
HHB: Hhub_1122(thi4)
HAGS: JT689_11965
HABO: JRZ79_10305
HNO: LT974_00705
HLU: LT972_12875
HSU: HLASF_0331
HSF: HLASA_0330
SALR: FQU85_03530
HALR: EFA46_011875
HJE: HacjB3_12970
HDO: MUK72_07875
HALX: M0R89_10525
HAXZ: M0R88_11005
HAYC: NGM10_05370
HAXY: NGM07_01030
SALI: L593_09560
SAIM: K0C01_03160
HARA: AArcS_1966(thi4)
HMA: rrnAC1782(thi1)
HHI: HAH_2313(thi1)
HHN: HISP_11780
HAB: SG26_04110
HTA: BVU17_11255
HALJ: G9465_07010
HSIN: KDQ40_01865
NPH: NP_5174A(thi4)
NMO: Nmlp_3882(thi4)
NHO: HWV23_12010
NSAL: HWV07_14560
HUT: Huta_2718
HTI: HTIA_2465
HALA: Hrd1104_02040
HASV: SVXHr_1858(thi4)
HABN: HBNXHr_1846(thi4)
HMU: Hmuk_0002
HALZ: E5139_03335
HALL: LC1Hm_2563(thi4)
HAZP: GBQ70_03335
HALI: BV210_05585
HSN: DV733_09670
HDS: HSR122_2321(thi4)
HRR: HZS55_08655
HPEL: HZS54_09780
HLT: I7X12_05325
HARC: HARCEL1_09615
HAAD: MW046_08650
HWA: HQ_1276A(thi4)
HWC: Hqrw_1306(thi4)
HVO: HVO_0665(thi4)
HME: HFX_0634
HGI: ABY42_03175
HALE: G3A49_03390
HLS: KU306_07905
HLN: SVXHx_0624(thi4)
HBO: Hbor_25460
HAQ: DU484_06390
HAJ: DU500_06660
HAER: DU502_04335
HRA: EI982_09275
HLM: DV707_12630
HLA: Hlac_2980
HALB: EKH57_08560
HEZZ: EO776_03960
HALQ: Hrr1229_002890
HSS: J7656_12905
HSAI: HPS36_03250
HAZZ: KI388_01415
SRUB: C2R22_02145
HAE: halTADL_1093
HALN: B4589_006725
HALG: HUG10_03970
HALU: HUG12_12960
HMP: K6T50_02080
HRE: K6T36_01900
HRM: K6T25_14540
HACB: Hbl1158_08970
HDF: AArcSl_1355(thi4)
HAH: Halar_3704
HTU: Htur_1462
HSAL: JMJ58_01385
HAKZ: J0X25_14155
NMG: Nmag_2419(thi4)
HXA: Halxa_2863
NAT: NJ7G_3680
NPE: Natpe_2830
NVR: FEJ81_13195
NPL: FGF80_13125
NAY: HYG81_16885
HALY: HYG82_19015
HJT: DVR14_04265
HLO: J0X27_03870
NGE: Natgr_0926
HRU: Halru_1150
SAWL: NGM29_17530
HALV: NGM15_08750
NOU: Natoc_0532
HLR: HALLA_10200
HLC: CHINAEXTREME16945
NAJ: B1756_03455
NAG: AArcMg_1121
NAN: AArc1_2501
NARA: QQ977_09420
NBG: DV706_12525
NAS: GCU68_13250
HDA: BB347_01930
MELU: MTLP_07010
MEAM: MU439_01690
MEAE: QEN48_00685
ABI: Aboo_0963
ACF: AciM339_1016
APE: APE_2149.1
ACJ: ACAM_1344
SMR: Smar_0052 Smar_0180
SHC: Shell_0764
IHO: Igni_0560
IIS: EYM_05510
IPC: IPA_05695
DKA: DKAM_0713
DFD: Desfe_0795
IAG: Igag_0295
THG: TCELL_1023
HBU: Hbut_0253
PFM: Pyrfu_0366
PDL: Pyrde_0220 Pyrde_0347
PABI: PABY_00710
STO: STK_03610
SOH: D1869_01525
SSO: SSO0436
SOL: Ssol_1411
SSOA: SULA_1456
SSOL: SULB_1457
SSOF: SULC_1455
SSHI: J5U23_03002
SCAS: SACC_05940
SAI: Saci_0854(thi)
SACN: SacN8_04145
SACR: SacRon12I_04135
SACS: SUSAZ_03885
SIS: LS215_1798
SIA: M1425_1670
SIM: M1627_1786
SID: M164_1717
SIY: YG5714_1786
SIN: YN1551_1140
SII: LD85_1927
SIH: SiH_1645
SIR: SiRe_1566
SIC: SiL_1558
SULA: BFU36_03640
SULE: GFS03_09395
SULO: GFS33_01210
SULL: EWF20_02995
MSE: Msed_2221
MEMJ: MJ1HA_2541
MCN: Mcup_0086
MHK: DFR87_07430
MPRU: DFR88_07115
MTEN: GWK48_04735
MJN: MjAS7_0513
AHO: Ahos_0692
AMAN: B6F84_06895
ABRI: DFR85_08045
ASUL: DFR86_05955
AAMB: D1866_11245
ACIH: HS5_20660
SACD: HS1genome_2409
SAZO: D1868_02625
CSTY: KN1_20130
STEP: IC006_1529
SMET: RQ359_000407
SAHS: HS7_05390
PAI: PAE0175
PIS: Pisl_1998
PCL: Pcal_1555
PAS: Pars_1498
PYR: P186_0936
POG: Pogu_0708
TNE: Tneu_1052
PYW: PYWP30_02101
CMA: Cmaq_1420
TUZ: TUZN_0079
VDI: Vdis_2373
VMO: VMUT_0723
VSO: Vsou_21150
FFO: FFONT_0392
NMR: Nmar_0678
NIR: NSED_03435
NKR: NKOR_03495
NID: NPIRD3C_1584
NIN: NADRNF5_1474
NIW: Nisw_01510
NCL: C5F47_05695
NOX: C5F49_05585
NUE: C5F50_04895
NIP: NsoK4_05025
NZT: NZOSNM25_001293
NCT: NMSP_1025
NIC: DSQ20_03585
NGA: Ngar_c21660
NVN: NVIE_008130
NEV: NTE_02257
TAA: NMY3_02935
NFN: NFRAN_0414(thi)
NCV: NCAV_0396(thi)
CSY: CENSYa_0361
NBV: T478_0555
TAH: SU86_002805
NIU: DSQ19_03795
NDV: NDEV_0758
CCAI: NAS2_0821
KCR: Kcr_0795
BARB: AOA66_0043
FLT: Sv326_1000
 » show all
Reference
1  [PMID:26919468]
  Authors
Zhang X, Eser BE, Chanani PK, Begley TP, Ealick SE
  Title
Structural Basis for Iron-Mediated Sulfur Transfer in Archael and Yeast Thiazole  Synthases.
  Journal
Biochemistry 55:1826-38 (2016)
DOI:10.1021/acs.biochem.6b00030
  Sequence
[mja:MJ_0601] [mig:Metig_0735]
Reference
2  [PMID:26928142]
  Authors
Eser BE, Zhang X, Chanani PK, Begley TP, Ealick SE
  Title
From Suicide Enzyme to Catalyst: The Iron-Dependent Sulfide Transfer in Methanococcus jannaschii Thiamin Thiazole Biosynthesis.
  Journal
J Am Chem Soc 138:3639-42 (2016)
DOI:10.1021/jacs.6b00445
  Sequence
[mja:MJ_0601]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.2.59
IUBMB Enzyme Nomenclature: 2.4.2.59
ExPASy - ENZYME nomenclature database: 2.4.2.59
BRENDA, the Enzyme Database: 2.4.2.59
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