KEGG ENZYME: 4.2.3.216

ENZYME: 4.2.3.216

Entry

EC 4.2.3.216                Enzyme

Name

somaliensene A synthase;
stsC (gene name)

Class

Lyases;
Carbon-oxygen lyases;
Acting on phosphates

Sysname

geranylfarnesyl-diphosphate diphosphate-lyase (cyclizing, somaliensene A-forming)

Reaction(IUBMB)

geranylfarnesyl diphosphate = somaliensene A + diphosphate [RN:R13231]

Reaction(KEGG)

R13231

Substrate

geranylfarnesyl diphosphate [CPD:C04217]

Product

somaliensene A [CPD:C22841];
diphosphate [CPD:C00013]

Comment

A sesterterpenoid synthase enzyme isolated from the bacterium Streptomyces somaliensis. The enzyme also produces somalensene B (cf. EC 4.2.3.217, somaliensene B synthase).

History

EC 4.2.3.216 created 2023

Orthology

K27204

somaliensene A/B synthase

Reference

1 [PMID:29553734]

Authors

Yang Y, Zhang Y, Zhang S, Chen Q, Ma K, Bao L, Tao Y, Yin W, Wang G, Liu H.

Title

Identification and Characterization of a Membrane-Bound Sesterterpene Cyclase from Streptomyces somaliensis.

Journal

J Nat Prod 81:1089-1092 (2018)
DOI:10.1021/acs.jnatprod.7b01033

Sequence

[ag:WP_010468024]

Other DBs

ExplorEnz - The Enzyme Database:

4.2.3.216

IUBMB Enzyme Nomenclature:

4.2.3.216

ExPASy - ENZYME nomenclature database:

4.2.3.216

BRENDA, the Enzyme Database:

4.2.3.216

LinkDB

DBGET integrated database retrieval system