ENZYME: 4.2.3.217
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Entry
EC 4.2.3.217 Enzyme
Name
somaliensene B synthase;
stsC (gene name)
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
geranylfarnesyl-diphosphate diphosphate-lyase (cyclizing, (-)-somaliensene B-forming)
Reaction(IUBMB)
geranylfarnesyl diphosphate = (-)-somaliensene B + diphosphate [RN:
R13232
]
Reaction(KEGG)
R13232
Reaction
Substrate
geranylfarnesyl diphosphate [CPD:
C04217
]
Product
(-)-somaliensene B [CPD:
C22842
];
diphosphate [CPD:
C00013
]
Comment
A sesterterpenoid synthase enzyme isolated from the bacterium Streptomyces somaliensis. The enzyme also produces somaliensene A (cf. EC
4.2.3.216
, somaliensene A synthase).
History
EC 4.2.3.217 created 2023
Orthology
K27204
somaliensene A/B synthase
Reference
1 [PMID:
29553734
]
Authors
Yang Y, Zhang Y, Zhang S, Chen Q, Ma K, Bao L, Tao Y, Yin W, Wang G, Liu H.
Title
Identification and Characterization of a Membrane-Bound Sesterterpene Cyclase from Streptomyces somaliensis.
Journal
J Nat Prod 81:1089-1092 (2018)
DOI:
10.1021/acs.jnatprod.7b01033
Sequence
[ag:
WP_010468024
]
Other DBs
ExplorEnz - The Enzyme Database:
4.2.3.217
IUBMB Enzyme Nomenclature:
4.2.3.217
ExPASy - ENZYME nomenclature database:
4.2.3.217
BRENDA, the Enzyme Database:
4.2.3.217
LinkDB
All DBs
DBGET
integrated database retrieval system