 | | DRUG: Paroxetine hydrochloride hemihydrate | |
| Entry |
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| Name |
Paroxetine hydrochloride hemihydrate (USP);
Paroxetine hydrochloride hydrate (JP18);
Paxil (TN) |
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| Product |
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| Generic |
PAROXETINE (A-S Medication Solutions), PAROXETINE (A-S Medication Solutions), PAROXETINE (ANI Pharmaceuticals), PAROXETINE (Advanced Rx Pharmacy of Tennessee), PAROXETINE (American Health Packaging), PAROXETINE (Aphena Pharma Solutions - Tennessee), PAROXETINE (Aphena Pharma Solutions - Tennessee), PAROXETINE (Aphena Pharma Solutions - Tennessee), PAROXETINE (Aphena Pharma Solutions - Tennessee), PAROXETINE (Aphena Pharma Solutions - Tennessee), PAROXETINE (Aphena Pharma Solutions - Tennessee), PAROXETINE (Aphena Pharma Solutions - Tennessee), PAROXETINE (Aurobindo Pharma Limited), PAROXETINE (Aurolife Pharma LLC), PAROXETINE (AvPAK), PAROXETINE (Bryant Ranch Prepack), PAROXETINE (Bryant Ranch Prepack), PAROXETINE (Bryant Ranch Prepack), PAROXETINE (Bryant Ranch Prepack), PAROXETINE (Bryant Ranch Prepack), PAROXETINE (Bryant Ranch Prepack), PAROXETINE (Bryant Ranch Prepack), PAROXETINE (Cadila Pharmaceuticals Limited), PAROXETINE (Chartwell RX), PAROXETINE (Chartwell RX), PAROXETINE (Direct_Rx), PAROXETINE (Lake Erie Medical DBA Quality Care Products LLC), PAROXETINE (Lupin Pharmaceuticals), PAROXETINE (McKesson Corporation dba SKY Packaging), PAROXETINE (Modavar Pharmaceuticals LLC), PAROXETINE (Mylan Pharmaceuticals), PAROXETINE (NCS HealthCare of KY), PAROXETINE (NCS HealthCare of KY), PAROXETINE (NorthStar Rx LLC), PAROXETINE (NuCare Pharmaceuticals), PAROXETINE (PD-Rx Pharmaceuticals), PAROXETINE (PD-Rx Pharmaceuticals), PAROXETINE (PD-Rx Pharmaceuticals), PAROXETINE (PD-Rx Pharmaceuticals), PAROXETINE (Preferred Pharmaceuticals), PAROXETINE (Preferred Pharmaceuticals), PAROXETINE (Preferred Pharmaceuticals), PAROXETINE (Proficient Rx LP), PAROXETINE (Proficient Rx LP), PAROXETINE (Proficient Rx LP), PAROXETINE (Proficient Rx LP), PAROXETINE (Proficient Rx LP), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (Rhodes Pharmaceuticals L.P.), PAROXETINE (Solco Healthcare US), PAROXETINE (St. Mary's Medical Park Pharmacy), PAROXETINE (St. Mary's Medical Park Pharmacy), PAROXETINE (Yiling Pharmaceutical), PAROXETINE (Zydus Lifesciences Limited), PAROXETINE (Zydus Pharmaceuticals USA), PAROXETINE HYDROCHLORIDE (Bryant Ranch Prepack), PAROXETINE HYDROCHLORIDE (Bryant Ranch Prepack), PAROXETINE HYDROCHLORIDE (Sinotherapeutics) |
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| Formula |
(C19H20FNO3. HCl)2. H2O
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| Exact mass |
748.2494
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| Mol weight |
749.668
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| Structure |
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| Class |
Neuropsychiatric agent
DG01659 Selective serotonin reuptake inhibitor (SSRI)
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
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| Remark |
| Therapeutic category: | 1179 |
| Product (DG00944): | D02260<JP/US> D05374<US> D05375<US> |
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| Efficacy |
Antidepressant, Selective serotonin reuptake inhibitor (SSRI) |
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| Disease |
Major depressive disorder [DS: H01646] Panic disorder [DS: H01664] Social anxiety disorder [DS: H01670] |
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| Comment |
Fluoxetine derivative
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| Target |
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| Pathway |
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| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
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| Interaction |
CYP inhibition: CYP2D6 [HSA: 1565]
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| Structure map |
| map07234 | Neurotransmitter transporter inhibitors |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06A ANTIDEPRESSANTS
N06AB Selective serotonin reuptake inhibitors
N06AB05 Paroxetine
D02260 Paroxetine hydrochloride hemihydrate (USP) <JP/US>
USP drug classification [BR:br08302]
Antidepressants
SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
Paroxetine
D02260 Paroxetine hydrochloride hemihydrate (USP)
Anxiolytics
SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
Paroxetine
D02260 Paroxetine hydrochloride hemihydrate (USP)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1179 Others
D02260 Paroxetine hydrochloride hemihydrate (USP); Paroxetine hydrochloride hydrate (JP18)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01659 Selective serotonin reuptake inhibitor (SSRI)
DG00944 Paroxetine
D02260 Paroxetine hydrochloride hemihydrate
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00944 Paroxetine
D02260 Paroxetine hydrochloride hemihydrate
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG00944 Paroxetine
D02260 Paroxetine hydrochloride hemihydrate
Drug classes [BR:br08332]
Neuropsychiatric agent
DG01659 Selective serotonin reuptake inhibitor (SSRI)
D02260 Paroxetine hydrochloride hemihydrate
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC6
SLC6A4 (HTT)
D02260 Paroxetine hydrochloride hemihydrate (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D02260 Paroxetine hydrochloride hydrate
D02260 Paroxetine hydrochloride tablets
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D02260
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D02260
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D02260
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01659 Selective serotonin reuptake inhibitor (SSRI)
DG00944 Paroxetine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00944 Paroxetine
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG00944 Paroxetine
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 51
1 O0 O 41.1566 -17.6442
2 C1y C 33.8100 -18.5500
3 C1y C 32.5500 -19.2500
4 C8y C 33.8100 -17.1500
5 C1x C 35.0000 -19.2500
6 C1b C 31.3600 -18.5500
7 C1x C 32.5500 -20.6500
8 C8x C 35.0000 -16.4500
9 C8x C 32.5500 -16.4500
10 C1x C 35.0000 -20.6500
11 O2a O 30.1700 -19.2500
12 N1x N 33.8100 -21.3500
13 C8x C 35.0000 -15.0500
14 C8x C 32.5500 -15.0500
15 C8y C 28.9100 -18.5500
16 C8y C 33.8100 -14.3500
17 C8x C 28.9100 -17.1500
18 C8x C 27.7200 -19.2500
19 X F 33.8100 -12.9500
20 C8y C 27.7200 -16.4500
21 C8x C 26.5300 -18.5500
22 C8y C 26.5300 -17.1500
23 O2x O 27.4400 -15.1200
24 O2x O 25.4800 -16.2400
25 C1x C 26.0400 -14.9100
26 X Cl 37.7300 -17.5700
27 C1y C 33.8100 -18.5500
28 C1y C 32.5500 -19.2500
29 C1b C 31.3600 -18.5500
30 O2a O 30.1700 -19.2500
31 C8y C 28.9100 -18.5500
32 C8x C 28.9100 -17.1500
33 C8y C 27.7200 -16.4500
34 C8y C 26.5300 -17.1500
35 C8x C 26.5300 -18.5500
36 C8x C 27.7200 -19.2500
37 O2x O 25.4800 -16.2400
38 C1x C 26.0400 -14.9100
39 O2x O 27.4400 -15.1200
40 C1x C 32.5500 -20.6500
41 N1x N 33.8100 -21.3500
42 C1x C 35.0000 -20.6500
43 C1x C 35.0000 -19.2500
44 C8y C 33.8100 -17.1500
45 C8x C 35.0000 -16.4500
46 C8x C 35.0000 -15.0500
47 C8y C 33.8100 -14.3500
48 C8x C 32.5500 -15.0500
49 C8x C 32.5500 -16.4500
50 X F 33.8100 -12.9500
51 X Cl 37.7300 -17.5700
BOND 54
1 14 16 1
2 21 22 1
3 24 25 1
4 2 3 1
5 2 4 1 #Down
6 2 5 1
7 3 6 1 #Up
8 3 7 1
9 4 8 2
10 4 9 1
11 5 10 1
12 6 11 1
13 7 12 1
14 8 13 1
15 9 14 2
16 11 15 1
17 13 16 2
18 15 17 2
19 15 18 1
20 16 19 1
21 17 20 1
22 18 21 2
23 20 22 2
24 20 23 1
25 22 24 1
26 23 25 1
27 10 12 1
28 48 47 1
29 35 34 1
30 37 38 1
31 27 28 1
32 27 44 1 #Down
33 27 43 1
34 28 29 1 #Up
35 28 40 1
36 44 45 2
37 44 49 1
38 43 42 1
39 29 30 1
40 40 41 1
41 45 46 1
42 49 48 2
43 30 31 1
44 46 47 2
45 31 32 2
46 31 36 1
47 47 50 1
48 32 33 1
49 36 35 2
50 33 34 2
51 33 39 1
52 34 37 1
53 39 38 1
54 42 41 1
BRACKET 1 25.0600 -22.8200 25.0600 -12.2500
1 38.5000 -12.2500 38.5000 -22.8200
1 2
ORIGINAL 1 2 3 6 11 15 17 20 22 21 18 24 25 23 7 12 10
1 5 4 8 13 16 14 9 19 26
REPEAT 1 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42
1 43 44 45 46 47 48 49 50 51
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