| Entry |
|
|---|
| Name |
Paroxetine mesylate (USAN);
Brisdelle (TN);
Pexeva (TN) |
|---|
| Product |
|
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| Generic |
|
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| Formula |
C19H20FNO3. CH4SO3
|
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| Exact mass |
425.1308
|
|---|
| Mol weight |
425.4711
|
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| Structure |
|
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| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01659 Selective serotonin reuptake inhibitor (SSRI)
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
|
|---|
| Remark |
| Product (DG00944): | D02260<JP/US> D05374<US> D05375<US> |
|
|---|
| Efficacy |
Antidepressant, Selective serotonin reuptake inhibitor (SSRI) |
|---|
| Disease |
Major depressive disorder [DS: H01646] Obsessive compulsive disorder [DS: H01450] Panic disorder [DS: H01664] Generalized anxiety disorder [DS: H01662] |
|---|
| Comment |
Fluoxetine derivative
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
|
|---|
| Interaction |
CYP inhibition: CYP2D6 [HSA: 1565]
|
|---|
| Structure map |
| map07234 | Neurotransmitter transporter inhibitors |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06A ANTIDEPRESSANTS
N06AB Selective serotonin reuptake inhibitors
N06AB05 Paroxetine
D05375 Paroxetine mesylate (USAN) <US>
USP drug classification [BR:br08302]
Antidepressants
SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
Paroxetine
D05375 Paroxetine mesylate (USAN)
Anxiolytics
SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
Paroxetine
D05375 Paroxetine mesylate (USAN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01659 Selective serotonin reuptake inhibitor (SSRI)
DG00944 Paroxetine
D05375 Paroxetine mesylate
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00944 Paroxetine
D05375 Paroxetine mesylate
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG00944 Paroxetine
D05375 Paroxetine mesylate
Drug classes [BR:br08332]
Neuropsychiatric agent
DG01659 Selective serotonin reuptake inhibitor (SSRI)
D05375 Paroxetine mesylate
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC6
SLC6A4 (HTT)
D05375 Paroxetine mesylate (USAN) <US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D05375
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D05375
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01659 Selective serotonin reuptake inhibitor (SSRI)
DG00944 Paroxetine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00944 Paroxetine
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG00944 Paroxetine
|
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| Other DBs |
|
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| LinkDB |
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| KCF data |
ATOM 29
1 C1y C 10.4825 -8.1745
2 C1y C 9.2690 -8.8721
3 C8y C 10.4883 -6.8611
4 C1x C 11.6958 -8.8721
5 C1b C 8.0556 -8.1745
6 C1x C 9.2690 -10.2791
7 C8x C 11.7018 -6.1634
8 C8x C 9.2748 -6.1634
9 C1x C 11.6958 -10.2791
10 O2a O 6.8361 -8.8721
11 N1x N 10.4825 -10.9766
12 C8x C 11.7018 -4.7624
13 C8x C 9.2748 -4.7566
14 C8y C 5.6226 -8.1686
15 C8y C 10.4883 -4.0589
16 C8x C 5.6286 -6.7733
17 C8x C 4.4151 -8.8781
18 X F 10.4942 -2.7982
19 C8y C 4.4208 -6.0699
20 C8x C 3.2016 -8.1745
21 C8y C 3.2016 -6.7733
22 O2x O 4.1337 -4.6456
23 O2x O 2.2048 -5.7829
24 C1x C 2.6857 -4.3996
25 O1d O 15.9383 -6.5271
26 S4a S 15.9383 -7.9217
27 C1a C 14.5438 -7.9217
28 O1d O 17.3329 -7.9217
29 O1d O 15.9383 -9.3162
BOND 31
1 1 2 1
2 1 3 1 #Down
3 1 4 1
4 2 5 1 #Up
5 2 6 1
6 3 7 2
7 3 8 1
8 4 9 1
9 5 10 1
10 6 11 1
11 7 12 1
12 8 13 2
13 10 14 1
14 12 15 2
15 14 16 2
16 14 17 1
17 15 18 1
18 16 19 1
19 17 20 2
20 19 21 2
21 19 22 1
22 21 23 1
23 22 24 1
24 9 11 1
25 13 15 1
26 20 21 1
27 23 24 1
28 25 26 2
29 26 27 1
30 26 28 1
31 26 29 2
|
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