| Entry |
|
|---|
| Name |
Paroxetine hydrochloride (USP);
Paxil (TN) |
|---|
| Product |
|
|---|
| Generic |
PAROXETINE (Aphena Pharma Solutions - Tennessee), PAROXETINE (Aphena Pharma Solutions - Tennessee), PAROXETINE (Apotex Corp.), PAROXETINE (Cardinal Health 107), PAROXETINE (DIRECT RX), PAROXETINE (Golden State Medical Supply), PAROXETINE (Major Pharmaceuticals), PAROXETINE (NuCare Pharmaceuticals), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (Westminster Pharmaceuticals), PAROXETINE HYDROCHLORIDE (Lannett Company), PAROXETINE HYDROCHLORIDE (Oxford Pharmaceuticals) |
|---|
| Formula |
C19H20FNO3. HCl
|
|---|
| Exact mass |
365.1194
|
|---|
| Mol weight |
365.8263
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Neuropsychiatric agent
DG01659 Selective serotonin reuptake inhibitor (SSRI)
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
|
|---|
| Remark |
| Product (DG00944): | D02260<JP/US> D05374<US> D05375<US> |
|
|---|
| Efficacy |
Antidepressant, Selective serotonin reuptake inhibitor (SSRI) |
|---|
| Disease |
Major depressive disorder [DS: H01646] Obsessive compulsive disorder [DS: H01450] Panic disorder [DS: H01664] Social anxiety disorder [DS: H01670] Generalized anxiety disorder [DS: H01662] |
|---|
| Comment |
Fluoxetine derivative
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
|
|---|
| Interaction |
CYP inhibition: CYP2D6 [HSA: 1565]
|
|---|
| Structure map |
| map07234 | Neurotransmitter transporter inhibitors |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06A ANTIDEPRESSANTS
N06AB Selective serotonin reuptake inhibitors
N06AB05 Paroxetine
D05374 Paroxetine hydrochloride (USP) <US>
USP drug classification [BR:br08302]
Antidepressants
SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
Paroxetine
D05374 Paroxetine hydrochloride (USP)
Anxiolytics
SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
Paroxetine
D05374 Paroxetine hydrochloride (USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01659 Selective serotonin reuptake inhibitor (SSRI)
DG00944 Paroxetine
D05374 Paroxetine hydrochloride
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00944 Paroxetine
D05374 Paroxetine hydrochloride
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG00944 Paroxetine
D05374 Paroxetine hydrochloride
Drug classes [BR:br08332]
Neuropsychiatric agent
DG01659 Selective serotonin reuptake inhibitor (SSRI)
D05374 Paroxetine hydrochloride
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC6
SLC6A4 (HTT)
D05374 Paroxetine hydrochloride (USP) <US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D05374
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D05374
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01659 Selective serotonin reuptake inhibitor (SSRI)
DG00944 Paroxetine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00944 Paroxetine
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG00944 Paroxetine
|
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| Other DBs |
|
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| LinkDB |
|
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| KCF data |
ATOM 25
1 C1y C 25.2966 -20.5661
2 C1y C 24.0856 -21.2622
3 C8y C 25.3023 -19.1620
4 C1x C 26.5074 -21.2622
5 C1b C 22.8746 -20.5661
6 C1x C 24.0856 -22.6663
7 C8x C 26.5133 -18.4659
8 C8x C 24.0913 -18.4659
9 C1x C 26.5074 -22.6663
10 O2a O 21.6576 -21.2622
11 N1x N 25.2966 -23.3626
12 C8x C 26.5133 -17.0677
13 C8x C 24.0913 -17.0619
14 C8y C 20.4465 -20.5601
15 C8y C 25.3023 -16.3657
16 C8x C 20.4525 -19.1679
17 C8x C 19.2415 -21.2681
18 X F 25.2381 -14.9675
19 C8y C 19.2472 -18.4659
20 C8x C 18.0305 -20.5661
21 C8y C 18.0305 -19.1679
22 O2x O 18.9607 -17.0911
23 O2x O 16.9891 -18.2260
24 C1x C 17.5624 -16.9391
25 X Cl 29.5912 -22.1540
BOND 27
1 1 2 1
2 1 3 1 #Down
3 1 4 1
4 2 5 1 #Up
5 2 6 1
6 3 7 2
7 3 8 1
8 4 9 1
9 5 10 1
10 6 11 1
11 7 12 1
12 8 13 2
13 10 14 1
14 12 15 2
15 14 16 2
16 14 17 1
17 15 18 1
18 16 19 1
19 17 20 2
20 19 21 2
21 19 22 1
22 21 23 1
23 22 24 1
24 9 11 1
25 13 15 1
26 20 21 1
27 23 24 1
|
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