KEGG ORTHOLOGY: K04423

ORTHOLOGY: K04423

Entry

K04423                      KO

Symbol

MAP3K12, MUK

Name

mitogen-activated protein kinase kinase kinase 12 [EC:2.7.11.25]

Pathway

map04010

MAPK signaling pathway

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04423  MAP3K12, MUK; mitogen-activated protein kinase kinase kinase 12
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04423  MAP3K12, MUK; mitogen-activated protein kinase kinase kinase 12
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     K04423  MAP3K12, MUK; mitogen-activated protein kinase kinase kinase 12
Protein kinases [BR:ko01001]
Serine/threonine kinases: TKL group
  MLK family
   K04423  MAP3K12, MUK; mitogen-activated protein kinase kinase kinase 12

Other DBs

GO:

0004709

Genes

HSA:	7786(MAP3K12)

PTR:	451940(MAP3K12)

PPS:	100983287(MAP3K12)

GGO:	101151387(MAP3K12)

PON:	100172208(MAP3K12)

NLE:	100596886(MAP3K12)

HMH:	116480994(MAP3K12)

MCC:	703059(MAP3K12)

MCF:	101925622(MAP3K12)

MTHB:

126931102

MNI:	105474270(MAP3K12)

CSAB:

103238400(MAP3K12)

CATY:

105580265(MAP3K12)

PANU:

101017764(MAP3K12)

TGE:	112635511(MAP3K12)

MLEU:

105548520(MAP3K12)

RRO:	104670592(MAP3K12)

RBB:	108514626(MAP3K12)

TFN:	117090029(MAP3K12)

PTEH:

111541924(MAP3K12)

CANG:

105503568(MAP3K12)

CJC:	100408788(MAP3K12)

SBQ:	101031938(MAP3K12)

CIMI:

108284878(MAP3K12)

CSYR:

103251679(MAP3K12)

MMUR:

105870789(MAP3K12)

LCAT:

123639759(MAP3K12)

PCOQ:

105817525(MAP3K12)

OGA:	100966986(MAP3K12)

MMU:	26404(Map3k12)

MCAL:

110311026(Map3k12)

MPAH:

110335072(Map3k12)

RNO:	25579(Map3k12)

MCOC:

116080495(Map3k12)

ANU:	117718612(Map3k12)

MUN:	110552314(Map3k12)

CGE:	100765738(Map3k12)

MAUA:

101823355(Map3k12)

PROB:

127226145(Map3k12)

PLEU:

114696615(Map3k12)

MORG:

121444251 121459840(Map3k12)

MFOT:

126491182

AAMP:

119822282(Map3k12)

NGI:	103738660(Map3k12)

HGL:	101702332(Map3k12)

CPOC:

100731317(Map3k12)

CCAN:

109684077(Map3k12)

DORD:

105997926(Map3k12)

DSP:	122124378(Map3k12)

PLOP:

125363880(Map3k12)

NCAR:

124982140

MMMA:

107148813(Map3k12)

OCU:

100358158

OPI:	101531726(MAP3K12)

TUP:	102474694(MAP3K12)

GVR:	103592973(MAP3K12)

CFA:	607170(MAP3K12)

CLUD:

112667177(MAP3K12)

VVP:	112921182(MAP3K12)

VLG:	121480332(MAP3K12)

NPO:	129517260(MAP3K12)

AML:	100469942(MAP3K12)

UMR:	103675534(MAP3K12)

UAH:	113257547(MAP3K12)

UAR:	123794692(MAP3K12)

ELK:

111157894

LLV:

125106027

MPUF:

101678451(MAP3K12)

MNP:	132019733(MAP3K12)

MLK:	131838686(MAP3K12)

NVS:	122892677(MAP3K12)

ORO:	101365423(MAP3K12)

EJU:	114225735(MAP3K12)

ZCA:	113921458(MAP3K12)

MLX:	118008785(MAP3K12)

NSU:	110577397(MAP3K12)

LWW:	102736835(MAP3K12)

FCA:	101087164(MAP3K12)

PYU:	121038481(MAP3K12)

PCOO:

112867283(MAP3K12)

PBG:	122473479(MAP3K12)

PVIV:

125171259(MAP3K12)

LRUF:

124502437

PTG:	102957300(MAP3K12)

PPAD:

109249200(MAP3K12)

PUC:

125919125

AJU:

106983084

HHV:	120247231(MAP3K12)

BTA:	505427(MAP3K12)

BOM:	102281279(MAP3K12)

BIU:	109559030(MAP3K12)

BBUB:

102394831(MAP3K12)

BBIS:

105001583(MAP3K12)

CHX:	102174723(MAP3K12)

OAS:	101102889(MAP3K12)

BTAX:

128047920(MAP3K12)

ODA:	120858298(MAP3K12)

CCAD:

122427765(MAP3K12)

MBEZ:

129536213(MAP3K12)

SSC:	100517714(MAP3K12)

CFR:	102518433(MAP3K12)

CBAI:

105076289(MAP3K12)

CDK:	105094560(MAP3K12)

VPC:	102543112(MAP3K12)

BACU:

103011832(MAP3K12)

BMUS:

118902857(MAP3K12)

OOR:	101282832(MAP3K12)

DLE:	111173936(MAP3K12)

PCAD:

102994311(MAP3K12)

PSIU:

116760116(MAP3K12)

NASI:

112394021(MAP3K12)

ECB:	100064002(MAP3K12)

EPZ:	103555565(MAP3K12)

EAI:	106835292(MAP3K12)

MYB:	102252114(MAP3K12)

MYD:	102773021(MAP3K12)

MMYO:

118649991(MAP3K12)

MLF:	102424732(MAP3K12)

PKL:	118728517(MAP3K12)

EFUS:

103285349(MAP3K12)

MNA:	107528308(MAP3K12)

DRO:	112318252(MAP3K12)

AJM:	119043520(MAP3K12)

PDIC:

114513734(MAP3K12)

PHAS:

123813008(MAP3K12)

MMF:	118624477(MAP3K12)

PPAM:

129084802(MAP3K12)

HAI:	109391825(MAP3K12)

RFQ:	117027960(MAP3K12)

PALE:

102893121(MAP3K12)

PGIG:

120602239(MAP3K12)

PVP:	105302651(MAP3K12)

RAY:	107509857(MAP3K12)

MJV:	108394776(MAP3K12)

TOD:	119247991(MAP3K12)

SARA:

101552421(MAP3K12)

SETR:

126022462(MAP3K12)

LAV:	100672580(MAP3K12)

TMU:

101348162

ETF:	101659398(MAP3K12)

DNM:	101443875(MAP3K12)

GAS:	123249530(MAP3K12)

SHR:	100913706(MAP3K12)

AFZ:

127538038

PCW:	110194151(MAP3K12)

OAA:	100092492(MAP3K12)

GGA:

101750513

PCOC:

116234941(MAP3K12)

CJO:	107306938(MAP3K12)

NMEL:

110390881(MAP3K12)

LSR:	110480535(MAP3K12)

PMOA:

120501824(MAP3K12)

OTC:	121335582(MAP3K12)

PRUF:

121356095(MAP3K12)

FAB:	101807474(MAP3K12)

OMA:	130265885(MAP3K12)

PHI:	102113468(MAP3K12)

PMAJ:

107198728(MAP3K12)

ETL:	114073458(MAP3K12)

ZLE:	135459070(MAP3K12)

SVG:	106863602(MAP3K12)

MMEA:

130587222(MAP3K12)

FPG:	101921723(MAP3K12)

FCH:	102046644(MAP3K12)

NNI:	104017546(MAP3K12)

TALA:

122153812(MAP3K12)

AFOR:

103898175(MAP3K12)

ACHC:

115351326(MAP3K12)

HLE:	104830322(MAP3K12)

AGEN:

126046620

SHAB:

115618622(MAP3K12)

CUCA:

104055650(MAP3K12)

NPD:	112958220(MAP3K12)

SCAM:

104145525(MAP3K12)

ASN:	102376392(MAP3K12)

AMJ:	102561424(MAP3K12)

CPOO:

109323212(MAP3K12)

GGN:	109295333(MAP3K12)

CMY:	102943511(MAP3K12)

CCAY:

125627597(MAP3K12)

DCC:	119846138(MAP3K12)

CPIC:

101948914(MAP3K12)

TST:	117889154(MAP3K12)

CABI:

116828472(MAP3K12)

MRV:	120391078(MAP3K12)

ACS:	100553164(map3k12)

ASAO:

132767665(MAP3K12)

PVT:	110074404(MAP3K12)

SUND:

121923821(MAP3K12)

PBI:	103053351(MAP3K12)

PMUR:

107291245(MAP3K12)

CTIG:

120309979(MAP3K12)

TSR:	106549757(MAP3K12)

PGUT:

117662663(MAP3K12)

APRI:

131189537(MAP3K12)

PTEX:

113445523(MAP3K12)

NSS:	113418477(MAP3K12)

VKO:	123029829(MAP3K12)

PMUA:

114593051(MAP3K12)

PRAF:

128406621(MAP3K12)

ZVI:	118077087(MAP3K12)

HCG:	128345500(MAP3K12)

GJA:	107119674(MAP3K12)

STOW:

125428499(MAP3K12)

EMC:	129346298(MAP3K12)

XLA:	100113430(map3k12.S) 100337576(map3k12.L)

XTR:	100488307(map3k12)

NPR:	108786829(MAP3K12)

RTEM:

120929334(MAP3K12)

BBUF:

120993780(MAP3K12)

BGAR:

122932958(MAP3K12)

MUO:	115464641(MAP3K12)

GSH:	117357651(MAP3K12)

DRE:	404626(map3k12)

SRX:	107711606 107715569

SANH:

107663586 107700967(map3k12)

SGH:	107550328(map3k12) 107569030

CCAR:

109051849 109051855

CAUA:

113053683 113109148

CGIB:

127964390 128019403

PTET:

122340425(map3k12)

LROH:

127171209(map3k12)

OMC:	131547056(map3k12)

PPRM:

120475124(map3k12)

MAMB:

125269670(map3k12)

CIDE:

127518306 127518754

MASI:

127447263 127448156

TROS:

130555970(map3k12)

TDW:	130427910(map3k12)

MANU:

129452040(map3k12)

IPU:

108265230

IFU:	128607679(map3k12)

PHYP:

113533175(map3k12)

SMEO:

124400330(map3k12)

TFD:	113658495(map3k12)

TVC:	132853660(map3k12)

TRN:	134318489(map3k12)

AMEX:

103046562(map3k12)

CMAO:

118813354(map3k12)

EEE:	113577270 113578945

CHAR:

105900012(map3k12)

TRU:	101069629 101078679

TFS:	130524810 130530354(map3k12)

TNG:	GSTEN00023658G001 GSTEN00027624G001

LCO:	104919956(map3k12) 104930685

NCC:	104942570 104967292

TBEN:

117479479(map3k12) 117489662

CGOB:

115008143(map3k12) 115011424

PGEO:

117446350 117450161(map3k12)

GACU:

117534241 117543010(map3k12)

EMAC:

134873525(map3k12) 134882503

ELY:	117257283 117258715(map3k12)

EFO:	125892319(map3k12) 125900135

PLEP:

121947222(map3k12) 121951036

SLUC:

116051353 116062037(map3k12)

ECRA:

117943579 117948021(map3k12)

ESP:	116688446(map3k12) 116692046

PFLV:

114554438 114559157

GAT:	120828914(map3k12) 120835454

PPUG:

119199454 119222295(map3k12) 119229469

AFB:	129099972(map3k12) 129106406

CLUM:

117730577 117734019(map3k12)

PSWI:

130199525(map3k12) 130208810

MSAM:

119885810 119904911(map3k12)

SCHU:

122863269 122882845(map3k12)

CUD:	121517814(map3k12) 121528178

ALAT:

119021789 119023423(map3k12)

MZE:	101478940(map3k12) 101486282

ONL:	100691392(map3k12) 100704313

OAU:	116310922(map3k12) 116320744

OLA:	101160549 101162759

OML:	112145378 112159714(map3k12)

CSAI:

133448310 133456812(map3k12)

XMA:	102221308 102234935

XCO:	114135267 114142698(map3k12)

XHE:	116710092 116727538

PRET:

103464416(map3k12) 103467635

PFOR:

103135949(map3k12) 103144046 103144052

PLAI:

106956721(map3k12) 106964810

PMEI:

106914723 106928535(map3k12)

GAF:	122833536 122839176(map3k12)

PPRL:

129354362 129370405(map3k12)

CVG:	107094819 107103341

CTUL:

119788986 119799173(map3k12)

GMU:	124856295 124865267(map3k12)

NFU:	107385314(map3k12) 107391116

KMR:	108231598 108232129(map3k12)

ALIM:

106514729(map3k12) 106527991

NWH:	119412415 119416812(map3k12)

AOCE:

111567030 111583777

MCEP:

124997944(map3k12) 125006186

CSEM:

103385579 103386381

POV:	109635271 109635388

SSEN:

122767610 122777159(map3k12)

HHIP:

117761905 117764522(map3k12)

HSP:	118105499 118110865(map3k12)

PPLT:

128442749(map3k12) 128458458

SMAU:

118309154 118317146(map3k12)

LCF:	108884837 108900211(map3k12)

SDU:	111217270 111223920(map3k12)

SLAL:

111654997 111670210(map3k12)

XGL:	120783325 120803319(map3k12)

HCQ:	109528236 109529244(map3k12)

SSCV:

125977854 125988090

SBIA:

133495502(map3k12) 133507503

PEE:	133409086 133417098(map3k12)

PTAO:

133483878 133488109(map3k12)

BPEC:

110164496 110171200(map3k12)

MALB:

109955638(map3k12) 109966142

BSPL:

114856403 114858871(map3k12)

SJO:	128355761 128357432(map3k12)

SASA:

106566170(map3k12) 106566706 106571953 106582660

STRU:

115166196 115168347 115207319(map3k12)

OTW:	112222148 112235847 112255227

OMY:	110492360 110493290 110532042(map3k12)

OGO:	124004207 124031741 124045718

ONE:	115102152 115117395 115131928 115144771

OKI:	109869399 109880531(map3k12) 109890133 109906971

OKE:	118359678 118361354(map3k12) 118380936

SALP:

111969658 112080866

SNH:	120020134 120058738(map3k12) 120061623 120065563

CCLU:

121538112 121545451 121574806 121578310

ELS:	105026325 105030567

SFM:	108928397 108930454

PKI:	111835238(map3k12) 111844712

AANG:

118211982(map3k12)

LOC:	102698941(map3k12)

PSPA:

121308942(map3k12)

ARUT:

117400879 117966950

PSEX:

120524948(map3k12)

LCM:	102362205(MAP3K12)

CMK:	103190676(map3k12)

PMRN:

116943840(MAP3K13)

LRJ:

133358320

HHAL:

106682372

MQU:	128994047 128994940

LSM:

PPOI:

DSV:

RMP:

VDE:	111250497 111251891

VJA:	111262739 111265063

DFR:

124494149

UDV:	129227481 129231176

SDM:	118191684 118193108

TSP:

Tsp_09483

BGT:

106074070

OVI:	T265_10093

ATEN:

PDAM:

SPIS:

HMG:

HSY:

CCI:	CC1G_01227

» show all

Reference

PMID:18855897

Authors

Craig EA, Stevens MV, Vaillancourt RR, Camenisch TD

Title

MAP3Ks as central regulators of cell fate during development.

Journal

Dev Dyn 237:3102-14 (2008)
DOI:10.1002/dvdy.21750

LinkDB

DBGET integrated database retrieval system