KEGG ORTHOLOGY: K04432

ORTHOLOGY: K04432

Entry

K04432                      KO

Symbol

MAP2K3, MKK3

Name

mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]

Pathway

map04010

MAPK signaling pathway

map04013

MAPK signaling pathway - fly

map04015

Rap1 signaling pathway

map04218

Cellular senescence

map04620

Toll-like receptor signaling pathway

map04624

Toll and Imd signaling pathway

map04664

Fc epsilon RI signaling pathway

map04668

TNF signaling pathway

map04714

Thermogenesis

map04750

Inflammatory mediator regulation of TRP channels

map04912

GnRH signaling pathway

map04935

Growth hormone synthesis, secretion and action

map04936

Alcoholic liver disease

map05014

Amyotrophic lateral sclerosis

map05022

Pathways of neurodegeneration - multiple diseases

map05132

Salmonella infection

map05135

Yersinia infection

map05145

Toxoplasmosis

map05161

Hepatitis B

map05169

Epstein-Barr virus infection

map05170

Human immunodeficiency virus 1 infection

map05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

map05417

Lipid and atherosclerosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   04013 MAPK signaling pathway - fly
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   04015 Rap1 signaling pathway
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   04668 TNF signaling pathway
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   04624 Toll and Imd signaling pathway
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   04664 Fc epsilon RI signaling pathway
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
  09152 Endocrine system
   04912 GnRH signaling pathway
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   04935 Growth hormone synthesis, secretion and action
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
  09159 Environmental adaptation
   04714 Thermogenesis
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   05161 Hepatitis B
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   05169 Epstein-Barr virus infection
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   05135 Yersinia infection
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   05022 Pathways of neurodegeneration - multiple diseases
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
Protein kinases [BR:ko01001]
Serine/threonine kinases: STE group
  STE7 family
   K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3

Other DBs

GO:

0004708

Genes

HSA:	5606(MAP2K3)

PTR:	107972404 112206088

PPS:	100975020 117978302

GGO:	101145420(MAP2K3)

PON:	100457536(MAP2K3)

NLE:	100588703(MAP2K3)

HMH:	116483006(MAP2K3)

MCC:	705195(MAP2K3)

MCF:	102116823(MAP2K3)

MTHB:

126939044

MNI:	105493311(MAP2K3)

CSAB:

103242535(MAP2K3)

CATY:

105593750(MAP2K3)

PANU:

101012583(MAP2K3)

TGE:	112608997(MAP2K3)

MLEU:

105554627(MAP2K3)

RRO:	104678467(MAP2K3)

RBB:	108521513(MAP2K3)

TFN:	117089741(MAP2K3)

PTEH:

111528301(MAP2K3)

CANG:

105526517(MAP2K3)

CJC:	100398593(MAP2K3)

SBQ:	101034633(MAP2K3)

CIMI:

108290685(MAP2K3)

CSYR:

103264569(MAP2K3)

MMUR:

105856318(MAP2K3)

LCAT:

123650554(MAP2K3)

PCOQ:

105816099(MAP2K3)

OGA:	100955929(MAP2K3)

MMU:	26397(Map2k3)

MCAL:

110304977(Map2k3)

MPAH:

110331197(Map2k3)

RNO:	303200(Map2k3)

MCOC:

116077938(Map2k3)

ANU:	117710465(Map2k3)

MUN:	110561677(Map2k3)

CGE:	100756793(Map2k3)

MAUA:

101838194(Map2k3)

PROB:

127219179(Map2k3)

PLEU:

114683276(Map2k3)

MORG:

121456403(Map2k3)

MFOT:

126514653

AAMP:

119813155(Map2k3)

NGI:	103724822(Map2k3)

HGL:	101718318(Map2k3)

CPOC:

100726100(Map2k3)

CCAN:

109692052(Map2k3)

DORD:

105985703(Map2k3)

DSP:	122103259(Map2k3)

PLOP:

125366093(Map2k3)

NCAR:

124980599

MMMA:

107157178

OCU:

100339953

OPI:	101517788(MAP2K3)

TUP:	102499419(MAP2K3)

GVR:	103599172(MAP2K3)

CFA:	489547(MAP2K3)

CLUD:

112647216(MAP2K3)

VVP:	112924977(MAP2K3)

VLG:	121499935(MAP2K3)

NPO:	129497110(MAP2K3)

AML:	100476678(MAP2K3)

UMR:	103658475(MAP2K3)

UAH:	113271318(MAP2K3)

UAR:	123779716(MAP2K3)

ELK:

111139240

LLV:

125087473

MPUF:

101679855(MAP2K3)

MNP:	132004567(MAP2K3)

MLK:	131816095(MAP2K3)

NVS:	122906843(MAP2K3)

ORO:	101378651(MAP2K3)

EJU:	114198178(MAP2K3)

ZCA:	113939775(MAP2K3)

MLX:	118000167(MAP2K3)

NSU:	110584435(MAP2K3)

LWW:	102725552(MAP2K3)

FCA:	101082274(MAP2K3)

PYU:	121015779(MAP2K3)

PCOO:

112857077(MAP2K3)

PBG:	122485071(MAP2K3)

PVIV:

125151879(MAP2K3)

LRUF:

124519494

PTG:	102949954(MAP2K3)

PPAD:

109245742(MAP2K3)

PUC:

125926929

AJU:

106981449

HHV:	120228759(MAP2K3)

BTA:	516039(MAP2K3)

BOM:	102267773(MAP2K3)

BIU:	109574182(MAP2K3)

BBUB:

102391709(MAP2K3)

BBIS:

104990647(MAP2K3)

CHX:	102173967(MAP2K3)

OAS:	101122959(MAP2K3)

BTAX:

128064641(MAP2K3)

ODA:	120867361(MAP2K3)

CCAD:

122443696(MAP2K3)

MBEZ:

129544242(MAP2K3)

SSC:	110256149(MAP2K3)

CFR:	102523780(MAP2K3)

CBAI:

105084150(MAP2K3)

CDK:	105100607(MAP2K3)

VPC:	102530139(MAP2K3)

BACU:

103019100(MAP2K3)

BMUS:

118886770(MAP2K3)

LVE:	103091611(MAP2K3)

OOR:	101275666(MAP2K3)

DLE:	111167700(MAP2K3)

PCAD:

102978047(MAP2K3)

PSIU:

116745655(MAP2K3)

NASI:

112404892(MAP2K3)

ECB:	100053481(MAP2K3)

EPZ:	103563092(MAP2K3)

EAI:	106825518(MAP2K3)

MYB:	102259712(MAP2K3)

MYD:	102765923(MAP2K3)

MMYO:

118662418

PKL:	118721075(MAP2K3)

EFUS:

103303990(MAP2K3)

MNA:	107542219(MAP2K3)

DRO:	112308621(MAP2K3)

SHON:

119002731(MAP2K3)

AJM:	119062274(MAP2K3)

PDIC:

114515272(MAP2K3)

PHAS:

123809430(MAP2K3)

MMF:	118641294(MAP2K3)

PPAM:

129068738(MAP2K3)

HAI:	109390353(MAP2K3)

RFQ:	117013305(MAP2K3) 117018399

PALE:

102886389(MAP2K3)

PGIG:

120589895(MAP2K3)

PVP:	105304165(MAP2K3)

RAY:	107506757(MAP2K3)

MJV:	108392844(MAP2K3)

TOD:	119230399(MAP2K3)

SARA:

101555912(MAP2K3)

SETR:

126013729(MAP2K3)

LAV:	100675607(MAP2K3)

TMU:

101355711

ETF:	101639675(MAP2K3)

MDO:	100016872(MAP2K3)

GAS:	123233796(MAP2K3)

SHR:	100925586(MAP2K3)

AFZ:

127563289

PCW:	110223168(MAP2K3)

OAA:	100080734(MAP2K3)

GGA:	416496(MAP2K3)

PCOC:

116237354(MAP2K3)

MGP:	100542290(MAP2K3)

CJO:	107320760(MAP2K3)

TPAI:

128079133(MAP2K3)

LMUT:

125700804(MAP2K3)

NMEL:

110405901(MAP2K3)

APLA:

101803371(MAP2K3)

ACYG:

106032094(MAP2K3)

CATA:

118256504(MAP2K3)

AFUL:

116495505(MAP2K3)

TGU:	100229860(MAP2K3)

LSR:	110481212(MAP2K3)

SCAN:

103817610(MAP2K3)

PMOA:

120513145(MAP2K3)

OTC:	121334535(MAP2K3)

PRUF:

121350851(MAP2K3)

GFR:	102039295(MAP2K3)

FAB:	101809415(MAP2K3)

OMA:	130259290(MAP2K3)

PHI:	102109535(MAP2K3)

PMAJ:

107211348(MAP2K3)

CCAE:

111936127(MAP2K3)

CCW:	104684789(MAP2K3)

CBRC:

103615404(MAP2K3)

ETL:	114060189(MAP2K3)

ZAB:	102069824(MAP2K3)

ZLE:	135454237(MAP2K3)

ACHL:

103807200(MAP2K3)

SVG:	106849913(MAP2K3)

MMEA:

130575698(MAP2K3)

HRT:	120759791(MAP2K3)

FPG:	101919170(MAP2K3)

FCH:	102052703(MAP2K3)

CLV:	102085143(MAP2K3)

EGZ:	104132608(MAP2K3)

NNI:	104015109(MAP2K3)

PCRI:

104033009

PLET:

104626208(MAP2K3)

EHS:

104511600

PCAO:

104043088

ACUN:

113485588(MAP2K3)

TALA:

104357596(MAP2K3)

PADL:

103918788(MAP2K3)

AFOR:

103904894(MAP2K3)

ACHC:

115335899(MAP2K3)

HALD:

104323060(MAP2K3)

HLE:	104833592(MAP2K3)

AGEN:

126034069

GCL:

127022624

CCRI:

104169564

CSTI:

104557393(MAP2K3)

CMAC:

104482374(MAP2K3)

MUI:	104544376(MAP2K3)

BREG:

104636685(MAP2K3)

FGA:	104081195(MAP2K3)

GSTE:

104262007(MAP2K3)

LDI:	104342452(MAP2K3)

MNB:

103769299

OHA:	104335669(MAP2K3)

NNT:	104408256(MAP2K3)

SHAB:

115607143

DPUB:

104296953(MAP2K3)

PGUU:

104469010(MAP2K3)

ACAR:

104522657(MAP2K3)

CPEA:

104385265(MAP2K3)

AVIT:

104270947(MAP2K3)

CVF:	104290138(MAP2K3)

RTD:	128913932(MAP2K3)

CUCA:

104062506(MAP2K3)

TEO:	104378316(MAP2K3)

BRHI:

104496252(MAP2K3)

AAM:

106486833

AROW:

112974370

NPD:	112960040(MAP2K3)

TGT:

104573266

DNE:	112980388(MAP2K3)

SCAM:

104150824(MAP2K3)

ASN:	102383945(MAP2K3)

AMJ:	102566638(MAP2K3)

CPOO:

109314684(MAP2K3)

GGN:	109294332(MAP2K3)

PSS:	102454019(MAP2K3)

CMY:	102939584(MAP2K3)

CCAY:

125643689(MAP2K3)

DCC:	119862777(MAP2K3)

CPIC:

101936976(MAP2K3)

TST:	117883675(MAP2K3)

CABI:

116826312(MAP2K3)

MRV:	120373319(MAP2K3)

ACS:	100561588(map2k3)

ASAO:

132780018

PVT:	110087206(MAP2K3)

SUND:

121914162(MAP2K3)

PBI:	103065723(MAP2K3)

CTIG:

120315718(MAP2K3)

PGUT:

117676778(MAP2K3)

APRI:

131185369(MAP2K3)

PTEX:

113438784(MAP2K3)

NSS:	113423604(MAP2K3)

VKO:	123024965(MAP2K3)

PMUA:

114584096(MAP2K3)

PRAF:

128401910(MAP2K3)

ZVI:	118092693(MAP2K3)

HCG:	128336632(MAP2K3)

GJA:

107120519

STOW:

125431737(MAP2K3)

EMC:	129338683(MAP2K3)

MUO:	115475373(MAP2K3)

GSH:	117345887(MAP2K3)

SFM:	108923933(map2k3) 108941534

PKI:	111836901 111847733(map2k3)

AANG:

118217046 118221019

LOC:	102691753(map2k3)

PSPA:

121300746 121330854

ARUT:

117418403 117431675

PSEX:

120543271(map2k6)

LCM:	102351267(MAP2K3)

CMK:	103185143(map2k6)

RTP:	109922694(map2k6)

CPLA:

122560779

HOC:

132825484

LERI:

129706817

DME:	Dmel_CG12244(lic)

DER:

6551001

DSE:

6618621

DSI:	Dsimw501_GD24803(Dsim_lic)

DYA:	Dyak_GE17041

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI16291

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:	108356723 108366167 108371601

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:	119631314 119643226

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ003157

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_200347

BANY:

112049528

MJU:	123871716 123871816

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:	110377974 135118475

HZE:

TNL:

SLIU:

OFU:

ATRA:

PXY:

PGW:

LGLY:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM372730

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_215363

DMK:

DPZ:

PVM:

PJA:

PCHN:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

VDE:

VJA:	111268332 111270513

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

TSP:

HRO:	HELRODRAFT_89696

LGI:	LOTGIDRAFT_199455

PVUL:

PCAN:

BGT:

HRF:

HRJ:

CVN:

OED:

DPOL:

OBI:

OSN:

LJP:	135462194 135467706

LAK:	106155871 106162688

SMM:	Smp_073490

SHX:	MS3_00003185(MAP2K6_1)

EGL:

EGR_04099

TAD:	TRIADDRAFT_21026

» show all

Reference

PMID:8900184

Authors

Moriguchi T, Toyoshima F, Gotoh Y, Iwamatsu A, Irie K, Mori E, Kuroyanagi N, Hagiwara M, Matsumoto K, Nishida E

Title

Purification and identification of a major activator for p38 from osmotically shocked cells. Activation of mitogen-activated protein kinase kinase 6 by osmotic shock, tumor necrosis factor-alpha, and H2O2.

Journal

J Biol Chem 271:26981-8 (1996)
DOI:10.1074/jbc.271.43.26981

Sequence

[hsa:5606] [mmu:26397]

Reference

PMID:8622669

Authors

Raingeaud J, Whitmarsh AJ, Barrett T, Derijard B, Davis RJ

Title

MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway.

Journal

Mol Cell Biol 16:1247-55 (1996)
DOI:10.1128/MCB.16.3.1247

Sequence

[hsa:5606]

LinkDB

DBGET integrated database retrieval system