KEGG ORTHOLOGY: K04981

ORTHOLOGY: K04981

Entry

K04981                      KO

Symbol

TRPM6, CHAK2

Name

transient receptor potential cation channel subfamily M member 6 [EC:2.7.11.1]

Pathway

map04978

Mineral absorption

Disease

H01210

Hypomagnesemia

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09154 Digestive system
   04978 Mineral absorption
    K04981  TRPM6, CHAK2; transient receptor potential cation channel subfamily M member 6
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04981  TRPM6, CHAK2; transient receptor potential cation channel subfamily M member 6
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04981  TRPM6, CHAK2; transient receptor potential cation channel subfamily M member 6
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04981  TRPM6, CHAK2; transient receptor potential cation channel subfamily M member 6
Protein kinases [BR:ko01001]
Serine/threonine kinases: Other
  Alpha family [OT]
   K04981  TRPM6, CHAK2; transient receptor potential cation channel subfamily M member 6
Ion channels [BR:ko04040]
Voltage-gated cation channels
  Transient receptor potential channel (TRP)
   K04981  TRPM6, CHAK2; transient receptor potential cation channel subfamily M member 6

Other DBs

GO:

0005262

TC:

1.A.4.5.8

Genes

HSA:	140803(TRPM6)

PTR:	472957(TRPM6)

PPS:	100993141(TRPM6)

GGO:	101141316(TRPM6)

PON:	100449302(TRPM6)

NLE:	100586509(TRPM6)

HMH:	116475159(TRPM6)

MCC:	706119(TRPM6)

MCF:	102114781(TRPM6)

MTHB:

126937756

MNI:	105498957(TRPM6)

CSAB:

103219595(TRPM6)

CATY:

105584190(TRPM6)

PANU:

101012927(TRPM6)

TGE:	112607973(TRPM6)

MLEU:

105530619(TRPM6)

RRO:	104682191(TRPM6)

RBB:	108542658(TRPM6)

TFN:	117098460(TRPM6)

PTEH:

111543353(TRPM6)

CANG:

105515245(TRPM6)

CJC:	100413008(TRPM6)

SBQ:	101049323(TRPM6)

CIMI:

108314329(TRPM6)

CSYR:

103276918(TRPM6)

MMUR:

105868711(TRPM6)

LCAT:

123646020(TRPM6)

PCOQ:

105810420(TRPM6)

OGA:	100941087(TRPM6)

MMU:	225997(Trpm6)

MCAL:

110285256(Trpm6)

MPAH:

110337260(Trpm6)

RNO:	293874(Trpm6)

MCOC:

116103644(Trpm6)

ANU:	117708674(Trpm6)

MUN:	110558143(Trpm6)

CGE:	100771631(Trpm6)

MAUA:

101833710(Trpm6)

PROB:

127229049(Trpm6)

PLEU:

114696925(Trpm6)

MORG:

121454716(Trpm6)

MFOT:

126512259

AAMP:

119805969(Trpm6)

NGI:	103737704(Trpm6)

HGL:	101707911(Trpm6)

CPOC:

100734915(Trpm6)

CCAN:

109674537 109700788

DORD:

105987196(Trpm6)

DSP:	122124675(Trpm6)

PLOP:

125340611(Trpm6)

NCAR:

124964611

MMMA:

107148207(Trpm6)

OCU:

100345554

OPI:	101531274(TRPM6)

TUP:	102471583(TRPM6) 102491536

GVR:	103595938(TRPM6)

CFA:	484163(TRPM6)

CLUD:

112644707(TRPM6)

VVP:	112922062(TRPM6)

VLG:	121484907(TRPM6)

NPO:	129500609(TRPM6)

AML:	100480512(TRPM6)

UMR:	103663270(TRPM6)

UAH:	113269845(TRPM6)

UAR:	123781501(TRPM6)

ELK:

111153633

LLV:

125083477

MPUF:

101677726(TRPM6)

MNP:	132024807(TRPM6)

MLK:	131812600(TRPM6)

NVS:	122917688(TRPM6)

EJU:

114202330

ZCA:	113934862(TRPM6)

MLX:	118026288(TRPM6)

NSU:	110584290(TRPM6)

LWW:	102740862(TRPM6)

FCA:	101092301(TRPM6)

PYU:	121013620(TRPM6)

PCOO:

112868628(TRPM6)

PBG:	122475270(TRPM6)

PVIV:

125150607(TRPM6)

LRUF:

124524080

PTG:	102950437(TRPM6)

PPAD:

109275383(TRPM6)

PUC:	125916978 125917489 125917491

AJU:

106982974

HHV:	120224899(TRPM6)

BTA:	527597(TRPM6)

BOM:	102283347(TRPM6)

BIU:	109562963(TRPM6)

BBUB:

102408750(TRPM6)

BBIS:

104992144(TRPM6)

CHX:	102185359(TRPM6)

OAS:	101114337(TRPM6)

BTAX:

128052840(TRPM6)

ODA:	120873841(TRPM6)

CCAD:

122453232(TRPM6)

MBEZ:

129556748(TRPM6)

SSC:	100157775(TRPM6)

CFR:	102519057(TRPM6)

CBAI:

105067525(TRPM6)

CDK:	105106142(TRPM6)

VPC:	102538362(TRPM6)

BACU:

103012230(TRPM6)

BMUS:

118897119(TRPM6)

LVE:	103087343(TRPM6)

OOR:	101270724(TRPM6)

DLE:	111174589(TRPM6)

PCAD:

102981038(TRPM6)

PSIU:

116755915(TRPM6)

NASI:

112395657(TRPM6)

ECB:	100054478(TRPM6)

EPZ:	103558420(TRPM6)

EAI:	106836091(TRPM6)

MYB:	102249828(TRPM6)

MYD:	102757488(TRPM6)

MMYO:

118667452(TRPM6)

MLF:	102420952(TRPM6)

PKL:	118716479(TRPM6)

EFUS:

103286655(TRPM6)

MNA:	107544979(TRPM6)

DRO:	112299668(TRPM6)

SHON:

118976043(TRPM6)

AJM:	119045576(TRPM6) 119045581

PDIC:

114490577(TRPM6)

PHAS:

123819833(TRPM6)

MMF:	118629592(TRPM6)

PPAM:

129078497(TRPM6)

HAI:	109387013(TRPM6)

RFQ:	117032302(TRPM6)

PALE:

102891157(TRPM6)

PGIG:

120585965(TRPM6)

PVP:	105304006(TRPM6)

RAY:	107511650(TRPM6)

MJV:	108390801(TRPM6)

TOD:	119230568(TRPM6)

SARA:

101539697(TRPM6)

SETR:

126003505(TRPM6)

LAV:	100660086(TRPM6)

ETF:	101643234(TRPM6)

DNM:	101415867(TRPM6)

MDO:	100020109(TRPM6)

GAS:	123249521(TRPM6)

SHR:	100917919(TRPM6)

AFZ:

127545051

PCW:	110223196(TRPM6)

OAA:	100075204(TRPM6)

GGA:	100859603(TRPM6)

PCOC:

116234685(TRPM6)

MGP:

100543277

CJO:	107306212(TRPM6)

TPAI:

128089429(TRPM6)

LMUT:

125687114(TRPM6)

NMEL:

110390035(TRPM6)

APLA:

110351192(TRPM6)

ACYG:

106044150(TRPM6)

CATA:

118253766(TRPM6)

AFUL:

116500558(TRPM6)

TGU:	100224433(TRPM6)

LSR:	110476496(TRPM6)

SCAN:

103821061(TRPM6)

PMOA:

120507042(TRPM6)

OTC:	121345380(TRPM6)

PRUF:

121365363(TRPM6)

GFR:	102032555(TRPM6)

FAB:	101813319(TRPM6)

OMA:

130265005

PHI:	102105266(TRPM6)

PMAJ:

107216044(TRPM6)

CCAE:

111941667(TRPM6)

CCW:	104685289(TRPM6)

CBRC:

103616447(TRPM6)

ETL:	114058706(TRPM6)

ZAB:	102061897(TRPM6)

ZLE:	135460100(TRPM6)

ACHL:

103797547(TRPM6)

SVG:	106859214(TRPM6)

MMEA:

130577362

HRT:	120765805(TRPM6)

FPG:	101916722(TRPM6)

FCH:	102058568(TRPM6)

CLV:	102098942(TRPM6)

EGZ:	104123829(TRPM6)

NNI:	104011393(TRPM6)

PCRI:

104028760

PLET:

104615249(TRPM6)

EHS:	104509979(TRPM6)

ACUN:

113490057(TRPM6)

TALA:

104359150(TRPM6)

PADL:

103920433(TRPM6)

AFOR:

103903984(TRPM6)

ACHC:

115336688(TRPM6)

HALD:

104320466(TRPM6)

HLE:	104832497(TRPM6)

AGEN:

126036103

GCL:

127027756

CCRI:

104160110(TRPM6)

CSTI:

104550663(TRPM6)

CMAC:

104481120(TRPM6)

MUI:

104546653

BREG:

104635142(TRPM6)

FGA:	104076223(TRPM6)

GSTE:

104265005(TRPM6)

LDI:	104352294(TRPM6)

MNB:	103772635(TRPM6)

OHA:	104333391(TRPM6)

NNT:	104407041(TRPM6)

SHAB:

115600802(TRPM6)

DPUB:

104301699(TRPM6)

PGUU:

104464196(TRPM6)

ACAR:

104520322(TRPM6)

CPEA:

104390623(TRPM6)

AVIT:

104275065(TRPM6)

CVF:	104287684(TRPM6)

RTD:	128902426(TRPM6)

CUCA:

104060434(TRPM6)

TEO:	104369673(TRPM6)

BRHI:

104493695

NPD:	112958202(TRPM6)

DNE:	112983250(TRPM6)

ASN:	102383374(TRPM6)

AMJ:	102570433(TRPM6)

CPOO:

109323607(TRPM6)

GGN:	109297584(TRPM6)

PSS:	102451955(TRPM6)

CMY:	102936673(TRPM6)

CCAY:

125637399(TRPM6)

DCC:	119856034(TRPM6)

CPIC:

101943674(TRPM6)

TST:	117879393(TRPM6)

CABI:

116839379(TRPM6)

MRV:	120408559(TRPM6)

ACS:	100562006(trpm6)

ASAO:

132765398(TRPM6)

PVT:	110075995(TRPM6)

SUND:

121922625(TRPM6)

PBI:	103050645(TRPM6)

PMUR:

107286166(TRPM6)

CTIG:

120316179(TRPM6)

TSR:	106539701(TRPM6)

PGUT:

117661436(TRPM6)

APRI:

131193200(TRPM6)

PTEX:

113438445(TRPM6)

NSS:	113414334(TRPM6)

VKO:	123031345(TRPM6)

PMUA:

114606395(TRPM6)

PRAF:

128423709(TRPM6)

ZVI:	118076710(TRPM6)

HCG:	128346804(TRPM6)

GJA:	107110738(TRPM6)

STOW:

125436852(TRPM6)

EMC:	129334411(TRPM6)

XLA:	108714521(trpm6.L)

XTR:	100487366(trpm6)

NPR:	108795305(TRPM6)

RTEM:

120914279(TRPM6)

BBUF:

120989149(TRPM6)

BGAR:

122933056(TRPM6)

MUO:

115463326

GSH:	117351445(TRPM6)

DRE:	100149353(trpm6)

SRX:	107730720 107744470

SANH:

107672704 107673408

SGH:	107592315 107599919

CCAR:

109081602 109083816

CAUA:

113049878

CGIB:

127957454

PTET:

122345078(trpm6)

LROH:

127165196(trpm6)

OMC:	131540074(trpm6)

PPRM:

120469928(trpm6)

RKG:	130078502(trpm6)

MAMB:

125266661(trpm6)

CIDE:

127512594

MASI:

127426599 127439568

TROS:

130564759(trpm6)

TDW:	130419053(trpm6)

MANU:

129440033(trpm6)

IPU:	108255945(trpm6)

IFU:	128625460(trpm6)

PHYP:

113542245

SMEO:

124380689(trpm6)

TFD:	113639358(trpm6)

TVC:	132854469(trpm6)

TRN:	134335747(trpm6)

AMEX:

103038531

CMAO:

118827442(trpm6)

EEE:

113588635

CHAR:

105902717(trpm6)

TRU:

101071857

TFS:	130525991(trpm6)

TNG:	GSTEN00007906G001

LCO:

104917868

TBEN:

117472969(trpm6)

CGOB:

115013000

PGEO:

117452070(trpm6)

GACU:

117544019(trpm6)

EMAC:

134873547(trpm6)

ELY:	117251932(trpm6)

EFO:	125889811(trpm6)

PLEP:

121944987(trpm6)

SLUC:

116062596(trpm6)

PFLV:

114556308

GAT:	120830738(trpm6)

PPUG:

119195902 119224638(trpm6)

AFB:	129100671(trpm6)

CLUM:

117735902(trpm6)

PSWI:

130196664(trpm6)

MSAM:

119891288(trpm6)

SCHU:

122876623(trpm6)

CUD:	121509334(trpm6)

ALAT:

119019232(trpm6)

MZE:

101470275

ONL:

100711567

OAU:	116324300(trpm6)

OLA:

101159200

OML:	112148677(trpm6)

CSAI:

133451614(trpm6)

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122828835(trpm6)

PPRL:

129372929(trpm6)

CVG:

107092757

CTUL:

119784949(trpm6)

GMU:	124878489(trpm6)

NFU:

107393684

KMR:	108236508(trpm6)

ALIM:

106520105

NWH:	119413628(trpm6)

AOCE:

111582188

MCEP:

125011775(trpm6)

CSEM:

103397405

POV:

109633834

SSEN:

122769306(trpm6)

HHIP:

117767612(trpm6)

HSP:	118115318(trpm6)

PPLT:

128438331(trpm6)

SMAU:

118314097(trpm6)

LCF:	108878239(trpm6)

SDU:

111229137

SLAL:

111644988

XGL:	120804742(trpm6)

HCQ:

109511275

SSCV:

125994661

SBIA:

133499150(trpm6)

PEE:	133399701(trpm6)

PTAO:

133475574(trpm6)

BPEC:

110169882

MALB:

109954800

BSPL:

114863175(trpm6)

SJO:	128365259(trpm6)

SASA:

106580069 106585702

STRU:

115164811 115199574

OTW:	112248183(trpm6) 112264136

OMY:	110525400 110535035

OGO:	124034521 124034896

ONE:	115111367 115140655

OKI:	109876795 116374849

OKE:	118357824 118392972

SALP:

111957921 111975125

SNH:	120050646 120063546

CCLU:

ELS:

SFM:

PKI:

AANG:

118206523(trpm6)

LOC:	102689776(trpm6)

PSPA:

121319002

ARUT:

117421403

PSEX:

120527370(trpm6)

LCM:	102346743(TRPM6)

CMK:	103182374(trpm6)

CPLA:

122560924(trpm6)

HOC:

LERI:

PMAX:

RPHI:

Reference

PMID:12032568

Authors

Schlingmann KP, Weber S, Peters M, Niemann Nejsum L, Vitzthum H, Klingel K, Kratz M, Haddad E, Ristoff E, Dinour D, Syrrou M, Nielsen S, Sassen M, Waldegger S, Seyberth HW, Konrad M

Title

Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family.

Journal

Nat Genet 31:166-70 (2002)
DOI:10.1038/ng889

Sequence

[hsa:140803]

LinkDB

DBGET integrated database retrieval system