KEGG ORTHOLOGY: K07416

KEGG

ORTHOLOGY: K07416

Entry

K07416                      KO

Symbol

CYP2F

Name

cytochrome P450 family 2 subfamily F [EC:1.14.14.1]

Pathway

Metabolism of xenobiotics by cytochrome P450

Chemical carcinogenesis - reactive oxygen species

Reaction

naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K07416  CYP2F; cytochrome P450 family 2 subfamily F
09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    K07416  CYP2F; cytochrome P450 family 2 subfamily F
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07416  CYP2F; cytochrome P450 family 2 subfamily F
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07416  CYP2F; cytochrome P450 family 2 subfamily F
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP2 family
   K07416  CYP2F; cytochrome P450 family 2 subfamily F

Genes

HSA:	1572(CYP2F1)

PTR:

PPS:	100974522(CYP2F1)

GGO:	101147001 101152395

PON:

NLE:

HMH:

MCC:	100424795 678696(CYP2F1)

MCF:	102125382(CYP2F1) 107128707

MTHB:

126942014 126942068

MNI:

CSAB:

CATY:

105598004 105598007 105598010 105598074

TGE:

MLEU:

RRO:

RBB:

TFN:

PTEH:

CJC:

SBQ:

CIMI:

108285767(CYP2F1)

CSYR:

MMUR:

LCAT:

PCOQ:

OGA:

MMU:	13107(Cyp2f2)

MCAL:

MPAH:

RNO:	54246(Cyp2f4)

MCOC:

ANU:

MUN:

CGE:

MAUA:

PROB:

PLEU:

MORG:

MFOT:

AAMP:

NGI:

HGL:

CPOC:

CCAN:

DORD:

105998029 106000879

DSP:	122097366 122097388

PLOP:

125338948 125339006

NCAR:

MMMA:

OCU:

OPI:

TUP:

GVR:

CFA:	612477(CYP2F1)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:

MLX:

NSU:

LWW:

FCA:	101087438(CYP2F1)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

PTG:

PPAD:

PUC:

AJU:

HHV:

BTA:	615697(CYP2F1)

BOM:

BIU:

BBUB:

BBIS:

CHX:	102191547(CYP2F3)

OAS:

BTAX:

ODA:	120859351 120872401

CCAD:

MBEZ:

SSC:

CFR:

CBAI:

CDK:

VPC:

BMUS:

OOR:

DLE:

PCAD:

NASI:

ECB:	100068315(CYP2F1) 100068334

EPZ:	103540570 103565413

EAI:	106843254 106843307

SHON:

AJM:

PDIC:

HAI:

RFQ:

PALE:

PGIG:

PVP:

RAY:

MJV:

TOD:

SARA:

SETR:

LAV:

TMU:

ETF:

MDO:	100018790(CYPIIF2)

GAS:

SHR:

AFZ:

PCW:

ASN:

AMJ:

CCAY:

DCC:

CPIC:

101941929 112058658

TST:	117888581 117888968

CABI:

MRV:

ACS:

ASAO:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

APRI:

PTEX:

VKO:

PMUA:

114603153 114603158

PRAF:

128420210 128420233

ZVI:

GJA:	107109903 107122449 107122689

STOW:

EMC:	129343135 129343137 129343138 129343139

XLA:	108698626(cyp2a6.13.L)

XTR:

NPR:	108794927 108802358 108802359

RTEM:

120913316 120913317 120913321

BBUF:

120977518 120977519 120977520 120977815 121009127 121009624

BGAR:

122919467 122924139 122924140 122946238 122946428 122946704

MUO:	115480019 115480205 115480206 115480696 115481126 115481127 115481128

GSH:	117364878 117365326 117365422 117365633 117366083 117366084

LERI:

SCLV:

HAZT:

ABRU:

UDV:	129221090 129221094 129224344

SDM:

PMEO:

RPHI:

Reference

PMID:1974816 (CYP2F1)

Authors

Nhamburo PT, Kimura S, McBride OW, Kozak CA, Gelboin HV, Gonzalez FJ

Title

The human CYP2F gene subfamily: identification of a cDNA encoding a new cytochrome P450, cDNA-directed expression, and chromosome mapping.

Journal

Biochemistry 29:5491-9 (1990)
DOI:10.1021/bi00475a012

Sequence

[hsa:1572]

Reference

PMID:1742282 (CYP2F2)

Authors

Ritter JK, Owens IS, Negishi M, Nagata K, Sheen YY, Gillette JR, Sasame HA

Title

Mouse pulmonary cytochrome P-450 naphthalene hydroxylase: cDNA cloning, sequence, and expression in Saccharomyces cerevisiae.

Journal

Biochemistry 30:11430-7 (1991)
DOI:10.1021/bi00112a009

Sequence

[mmu:13107]

Reference

PMID:9448722 (CYP2F3)

Authors

Wang H, Lanza DL, Yost GS

Title

Cloning and expression of CYP2F3, a cytochrome P450 that bioactivates the selective pneumotoxins 3-methylindole and naphthalene.

Journal

Arch Biochem Biophys 349:329-40 (1998)
DOI:10.1006/abbi.1997.0479

Sequence

[chx:102191547]

Reference

PMID:15509722 (CYP2F4)

Authors

Baldwin RM, Shultz MA, Buckpitt AR.

Title

Bioactivation of the pulmonary toxicants naphthalene and 1-nitronaphthalene by rat CYP2F4.

Journal

J Pharmacol Exp Ther 312:857-65 (2005)
DOI:10.1124/jpet.104.075440

Sequence

[rno:54246]

LinkDB

DBGET integrated database retrieval system