KEGG ORTHOLOGY: K09479

ORTHOLOGY: K09479

Entry

K09479                      KO

Symbol

ACADVL

Name

very long chain acyl-CoA dehydrogenase [EC:1.3.8.9]

Pathway

map00071

Fatty acid degradation

map01100

Metabolic pathways

map01212

Fatty acid metabolism

map04936

Alcoholic liver disease

Module

M00087

beta-Oxidation

Reaction

R01279

palmitoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

R03990

tetradecanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Disease

H00392

VLCAD deficiency

H00525

Disorders of mitochondrial fatty-acid oxidation

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00071 Fatty acid degradation
    K09479  ACADVL; very long chain acyl-CoA dehydrogenase
09160 Human Diseases
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K09479  ACADVL; very long chain acyl-CoA dehydrogenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.8  With a flavin as acceptor
    1.3.8.9  very-long-chain acyl-CoA dehydrogenase
     K09479  ACADVL; very long chain acyl-CoA dehydrogenase

Other DBs

GO:

0017099

Genes

HSA:	37(ACADVL)

PTR:	455237(ACADVL)

PPS:	100986379(ACADVL)

GGO:	101143346(ACADVL)

PON:	100454381(ACADVL)

NLE:	100585921(ACADVL)

HMH:	116459317(ACADVL)

MCC:	714326(ACADVL)

MCF:	101925858(ACADVL)

MTHB:

126939682

MNI:	105473163(ACADVL)

CSAB:

103242278(ACADVL)

CATY:

105582769(ACADVL)

PANU:

101018882(ACADVL)

TGE:	112608977(ACADVL)

MLEU:

105549907(ACADVL)

RRO:	104673335(ACADVL)

RBB:	108514298(ACADVL)

TFN:	117067801(ACADVL)

PTEH:

111521283(ACADVL)

CANG:

105523588(ACADVL)

CJC:	100399197(ACADVL)

SBQ:	101028298(ACADVL)

CIMI:

108306602(ACADVL)

CSYR:

103263239(ACADVL)

MMUR:

105877978(ACADVL)

LCAT:

123650853(ACADVL)

PCOQ:

105819433(ACADVL)

OGA:	100947350(ACADVL)

MMU:	11370(Acadvl)

MCAL:

110304163(Acadvl)

MPAH:

110332221(Acadvl)

RNO:	25363(Acadvl)

MCOC:

116079063(Acadvl)

ANU:	117711753(Acadvl)

MUN:	110555097(Acadvl)

CGE:	100767527(Acadvl)

MAUA:

101824933(Acadvl)

PROB:

127219014(Acadvl)

PLEU:

114693210(Acadvl)

MORG:

121456541(Acadvl)

MFOT:

126513897

AAMP:

119811176(Acadvl)

NGI:	103752159(Acadvl)

HGL:	101707761(Acadvl)

CPOC:

100713909(Acadvl)

CCAN:

109674520(Acadvl)

DORD:

105983460(Acadvl)

DSP:	122100421(Acadvl)

PLOP:

125365206(Acadvl)

NCAR:

124981031

MMMA:

107157970(Acadvl)

OCU:

100346654

OPI:	101517023(ACADVL)

TUP:	102486032(ACADVL)

GVR:	103591441(ACADVL)

CFA:	489463(ACADVL)

CLUD:

112647487(ACADVL)

VVP:	112924990(ACADVL)

VLG:	121499762(ACADVL)

NPO:	129496982(ACADVL)

AML:	100472785(ACADVL)

UMR:	103660348(ACADVL)

UAH:	113271108(ACADVL)

UAR:	123792174(ACADVL)

ELK:

111161073

LLV:

125087809

MPUF:

101679496(ACADVL)

MNP:	132003338(ACADVL)

MLK:	131815752(ACADVL)

NVS:	122906685(ACADVL)

ORO:	101376612(ACADVL)

EJU:	114225362(ACADVL)

ZCA:	113939372(ACADVL)

MLX:	117999991(ACADVL)

NSU:	110584452(ACADVL)

LWW:	102738302(ACADVL)

FCA:	101094144(ACADVL)

PYU:	121016030(ACADVL)

PCOO:

112856982

PBG:	122484852(ACADVL)

PVIV:

125151822(ACADVL)

LRUF:

124519482

PTG:	102968012(ACADVL)

PPAD:

109245981(ACADVL)

PUC:

125927068

AJU:

106972414

HHV:	120231442(ACADVL)

BTA:	282130(ACADVL)

BOM:

102273950

BIU:	109573934(ACADVL)

BBUB:

102405745(ACADVL)

BBIS:

104993930(ACADVL)

CHX:	102181987(ACADVL)

OAS:	101117173(ACADVL)

BTAX:

128064846(ACADVL)

ODA:	120866080(ACADVL)

CCAD:

122446217(ACADVL)

MBEZ:

129542624(ACADVL)

SSC:	100520636(ACADVL)

CFR:	102516576(ACADVL)

CBAI:

105077481(ACADVL)

CDK:	105103048(ACADVL)

VPC:	102539565(ACADVL)

BACU:

103000307(ACADVL)

BMUS:

118886462(ACADVL)

LVE:	103077095(ACADVL)

OOR:	101275668(ACADVL)

DLE:	111185665(ACADVL)

PCAD:

102973774(ACADVL)

PSIU:

116745056(ACADVL)

NASI:

112390407(ACADVL)

ECB:	100061583(ACADVL)

EPZ:	103557744(ACADVL)

EAI:	106844174(ACADVL)

MYB:	102257348(ACADVL)

MYD:	102774563(ACADVL)

MMYO:

118672042(ACADVL)

MLF:	102423177(ACADVL)

PKL:	118726931(ACADVL)

EFUS:

103296934(ACADVL)

MNA:	107544584(ACADVL)

DRO:	112308631(ACADVL)

SHON:

118974685(ACADVL)

AJM:	119037137(ACADVL)

PDIC:

114514993(ACADVL)

PHAS:

123809242(ACADVL)

MMF:	118633802(ACADVL)

PPAM:

129072309(ACADVL)

HAI:	109394616(ACADVL)

RFQ:	117012846(ACADVL)

PALE:

102879612(ACADVL)

PGIG:

120589632(ACADVL)

PVP:	105291734(ACADVL)

RAY:	107509515(ACADVL)

MJV:	108401220(ACADVL)

TOD:	119232659(ACADVL)

SARA:

101545206(ACADVL)

SETR:

125998010(ACADVL)

LAV:	100657276(ACADVL)

TMU:

101361348

ETF:	101645138(ACADVL)

DNM:	101438130(ACADVL)

MDO:	100016619(ACADVL) 100032148

GAS:	123242000 123244462(ACADVL)

SHR:	100925698 100931501(ACADVL)

AFZ:	127558293 127560911

PCW:	110193114 110194404(ACADVL)

OAA:	100089853(ACADVL)

LSR:	110482134(ACADVL)

CCAE:

111922435(ACADVL)

SVG:	106864280(ACADVL)

ACHC:

115338360(ACADVL)

AGEN:

126034670

AAM:	106485823(ACADVL)

AROW:

112962139(ACADVL) 112963323

NPD:	112947461(ACADVL)

TGT:	104573439(ACADVL)

DNE:	112981697(ACADVL)

SCAM:

104153221(ACADVL)

ASN:	102371669 102384902(ACADVL)

AMJ:	102568802(ACADVL) 102576922

CPOO:

109308570(ACADVL)

GGN:	109288127(ACADVL)

PSS:	102443861(ACADVL) 102456803

CMY:	102938508(ACADVL)

CCAY:

125628616(ACADVL) 125642751

DCC:	119849363 119861618 122457698

CPIC:

101946768 101948805(ACADVL)

TST:	117883233(ACADVL)

CABI:

116828964 116839188(ACADVL)

MRV:	120372442 120381766(ACADVL)

ASAO:

132777544(ACADVL)

PVT:	110082312(ACADVL)

SUND:

121933466(ACADVL)

PBI:	103051941 103059781(ACADVL)

PMUR:

107291707 107295343(ACADVL)

CTIG:

120305692(ACADVL) 120307167

TSR:	106542417(ACADVL) 106551584

PGUT:

117656436 117659250 117669843

APRI:

131196872(ACADVL) 131200568

PTEX:

113450919(ACADVL)

NSS:	113425170(ACADVL)

VKO:	123016648(ACADVL)

PMUA:

114581599(ACADVL) 114598214

PRAF:

128400158(ACADVL) 128414927

ZVI:	118093983 118094793(ACADVL)

HCG:	128331405(ACADVL) 128349410

GJA:	107118083(ACADVL) 107125630

STOW:

125445140(ACADVL)

EMC:	129331940 129340369(ACADVL)

XLA:	108711808(acadvl.L)

XTR:	100216267(acadvl)

RTEM:

120921798(ACADVL)

BBUF:

120986711(ACADVL)

BGAR:

122922346(ACADVL)

MUO:	115457771(ACADVL)

GSH:	117350647(ACADVL)

DRE:	573723(acadvl)

SRX:	107731915 107738021

SANH:

107675499 107683542(acadvl)

SGH:	107595296 107597078

CCAR:

109073618 109092601

CAUA:

113052224 113105619

CGIB:

127961630 128017217

PTET:

122349779(acadvl)

LROH:

127167632(acadvl)

OMC:	131543239(acadvl)

PPRM:

120469949(acadvl)

RKG:	130091451(acadvl)

MAMB:

125265528(acadvl)

CIDE:

127515814

MASI:

127415437 127417077 127433914

TROS:

130545585 130546066(acadvl) 130550983

TDW:	130417368(acadvl) 130419068

MANU:

129438883(acadvl)

IPU:

108267840

IFU:	128610167(acadvl)

PHYP:

113540141(acadvl)

SMEO:

124387396(acadvl)

TFD:	113654726(acadvl)

TVC:	132848746(acadvl)

TRN:	134312374(acadvl)

AMEX:

103045531(acadvl)

CMAO:

118826677(acadvl)

EEE:	113567683(acadvl)

CHAR:

105906682 105907142(acadvl)

TRU:	101069830(acadvl)

TFS:	130522023(acadvl)

TNG:	GSTEN00019248G001

LCO:	104937817(acadvl)

NCC:

104942951

TBEN:

117488099(acadvl)

CGOB:

115023469(acadvl)

PGEO:

117463629(acadvl)

GACU:

117552716(acadvl)

EMAC:

134876077(acadvl)

ELY:	117246106(acadvl)

EFO:	125883637(acadvl)

SLUC:

116048989(acadvl)

ECRA:

117934572(acadvl)

ESP:	116686337(acadvl)

PFLV:

114545512(acadvl)

GAT:	120821571(acadvl)

PPUG:

119222335(acadvl)

AFB:	129093499(acadvl)

CLUM:

117747431(acadvl)

PSWI:

130211767(acadvl)

MSAM:

119911752(acadvl)

SCHU:

122870721(acadvl)

CUD:	121504728(acadvl)

ALAT:

119026810(acadvl)

MZE:	101472773(acadvl)

ONL:	100703037(acadvl)

OAU:	116330727(acadvl)

OLA:	101165349(acadvl)

OML:	112156048(acadvl)

CSAI:

133420004(acadvl)

XMA:	102217028(acadvl)

XCO:	114157390(acadvl)

XHE:	116732534(acadvl)

PRET:

103480485(acadvl)

PFOR:

103137528(acadvl)

PLAI:

106945534(acadvl)

PMEI:

106906747(acadvl)

GAF:	122819841(acadvl)

PPRL:

129379427(acadvl)

CVG:	107087781(acadvl)

CTUL:

119789781(acadvl)

GMU:	124880174(acadvl)

NFU:	107372430(acadvl)

KMR:	108241814(acadvl)

ALIM:

106529201(acadvl)

NWH:	119416326(acadvl)

AOCE:

111575585(acadvl)

MCEP:

124997830(acadvl)

CSEM:

103386901(acadvl)

POV:	109634887(acadvl)

SSEN:

122766124(acadvl)

HHIP:

117752053(acadvl)

HSP:	118102302(acadvl)

PPLT:

128430467(acadvl)

SMAU:

118317852(acadvl)

LCF:

108897054

SDU:	111232992(acadvl)

SLAL:

111665745(acadvl)

XGL:	120797419(acadvl)

HCQ:	109506947(acadvl)

SSCV:

125981931

SBIA:

133494776(acadvl)

PEE:	133397629(acadvl)

PTAO:

133472714(acadvl)

BPEC:

110157677(acadvl)

MALB:

109966474(acadvl)

BSPL:

114843947(acadvl)

SJO:	128383753(acadvl)

SASA:

106602820(acadvl)

STRU:

115155021(acadvl)

OTW:	112216747(acadvl)

OMY:	110490130(acadvl)

OGO:	123994754(acadvl)

ONE:	115106836(acadvl)

OKI:	109864415(acadvl)

OKE:	118365919(acadvl)

SALP:

111950426(acadvl)

SNH:	120057400(acadvl)

CCLU:

121579727(acadvl)

ELS:	105010800(acadvl)

SFM:	108918781(acadvl) 108923151

PKI:	111860921(acadvl)

AANG:

118222760(acadvl)

LOC:	102693936(acadvl)

PSPA:

121306545(acadvl)

ARUT:

117404600 117967919

PSEX:

120524994(acadvl)

LCM:	102364546(ACADVL)

RTP:	109918899(acadvl)

CPLA:

122544279(acadvl) 122556076

HOC:	132821718 132835154

LERI:

129694004(acadvl) 129703268

PMRN:

116944603(ACADVL)

LRJ:	133340840(ACADVL)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG7461(Acadvl)

DER:

6547331

DSE:

6609917

DSI:	Dsimw501_GD11444(Dsim_GD11444)

DYA:	Dyak_GE12038

DAN:

DSR:

DPO:

DPE:

DMN:

DGR:

DMO:	Dmoj_GI12099

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:	108354643 108361541 108378210

AOQ:

TDA:

MDE:

SCAC:

LCQ:	111683083 111683088 111683092

LSQ:	119608560 119608561 119608567

GFS:

ECOE:

CLON:

HIS:

AGA:	1275626 133393306 133394118 133394119

ACOZ:

120958362 120958363 120958364 120958365

AARA:

120901834 120902053 120902103 120904618

AMER:

121597151 121597152 121597153 121597155

ASTE:

118511710 118511711 118511712 118511713

AFUN:

125766327 125766329 125766330 125766331

AMOU:

128302062 128302063 128304425 128305932

AALI:

118462065 118462066 118462067

AAG:	23687873 5565366 5565367

AALB:

109400327 109400349 109425168 109425169

CQU:	CpipJ_CPIJ016451 CpipJ_CPIJ016452 CpipJ_CPIJ016453 CpipJ_CPIJ016454

CPII:

120417357 120417361 120417378

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

DVV:

NVL:	108562362 108569494

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_210602

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HZE:

TNL:

SLIU:

OFU:

PGW:

CFEL:

CCRN:

API:

DNX:

AGS:	114127836 114127838

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM617730

FOC:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_327246

DMK:

116922047

DPZ:

124336955

PVM:	113813193 113823665

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:	121122352 121126155

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:	129219424 129232459

SDM:	118184637 118199840

LPOL:

106465874

PMEO:

129599287

CEL:	CELE_E04F6.5(acdh-12)

CBR:

CBG_13088

CRQ:	GCK72_006440

NAI:	NECAME_17750

BMY:	BM_BM3112(Bma-acdh-12)

LOA:	LOAG_00695

TSP:

Tsp_10283

HRO:	HELRODRAFT_186034

LGI:	LOTGIDRAFT_177715

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

OVI:	T265_06522

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

TAD:	TRIADDRAFT_20833 TRIADDRAFT_23854 TRIADDRAFT_30874 TRIADDRAFT_31731 TRIADDRAFT_31757 TRIADDRAFT_31810 TRIADDRAFT_34622

AQU:

100638454

GAU:

GAU_0440

» show all

Reference

PMID:1730632

Authors

Izai K, Uchida Y, Orii T, Yamamoto S, Hashimoto T

Title

Novel fatty acid beta-oxidation enzymes in rat liver mitochondria. I. Purification and properties of very-long-chain acyl-coenzyme A dehydrogenase.

Journal

J Biol Chem 267:1027-33 (1992)

Sequence

[rno:25363]

Reference

PMID:7769092

Authors

Aoyama T, Souri M, Ushikubo S, Kamijo T, Yamaguchi S, Kelley RI, Rhead WJ, Uetake K, Tanaka K, Hashimoto T

Title

Purification of human very-long-chain acyl-coenzyme A dehydrogenase and characterization of its deficiency in seven patients.

Journal

J Clin Invest 95:2465-73 (1995)
DOI:10.1172/JCI117947

Sequence

[hsa:37]

LinkDB

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