KEGG   ORTHOLOGY: K15739
Entry
K15739                      KO                                     
Symbol
vanB, vanA, vanD
Name
D-alanine---(R)-lactate ligase [EC:6.1.2.1]
Pathway
map01502  Vancomycin resistance
map02020  Two-component system
Module
M00651  Vancomycin resistance, D-Ala-D-Lac type
Reaction
R09588  D-alanine:(R)-lactate ligase (ADP-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   02020 Two-component system
    K15739  vanB, vanA, vanD; D-alanine---(R)-lactate ligase
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01502 Vancomycin resistance
    K15739  vanB, vanA, vanD; D-alanine---(R)-lactate ligase
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K15739  vanB, vanA, vanD; D-alanine---(R)-lactate ligase
Enzymes [BR:ko01000]
 6. Ligases
  6.1  Forming carbon-oxygen bonds
   6.1.2  acid-alcohol ligases (ester synthases)
    6.1.2.1  D-alanine---(R)-lactate ligase
     K15739  vanB, vanA, vanD; D-alanine---(R)-lactate ligase
Antimicrobial resistance genes [BR:ko01504]
 Gene sets
  Vancomycin resistance modules
   Vancomycin resistance, D-Ala-D-Lac type
    K15739  vanB, vanA, vanD; D-alanine---(R)-lactate ligase
Genes
ASED: IRT44_16970(vanA)
BAYD: BSPP4475_08375(vanA)
PLV: ERIC2_c07960(vanA)
PSON: JI735_32490(vanA)
PMAE: LMZ02_20975(vanA)
TVU: AB849_010220(vanA)
LAH: LA20533_00580
EFA: EF2294(vanB)
EFC: EFAU004_02775(vanB)
EFAU: EFAU085_00735(vanB)
ESG: EsVE80_p1-00080(vanA)
CARG: RSJ17_20565
RGV: NQ502_10130(vanD)
DSY: DSY3690
DHD: Dhaf_1664
DDL: Desdi_1473
FWA: DCMF_02700(vanB)
BLAR: LC508_18525(vanD)
AMIC: Ami3637_13565(vanA)
EEH: LLS04_06405
LCG: L3BBH23_19240(vanB)
OLS: Olsu_1201
TIO: INP52_03930
NTP: CRH09_30840(vanB)
NWL: NWFMUON74_45700
TPR: Tpau_0523
TOY: FO059_01075(vanA)
SCO: SCO3595(vanB)
SLV: SLIV_20320
SXI: SXIM_54620
STRC: AA958_28375(vanB)
SLS: SLINC_1844
SAQU: EJC51_03785(vanA)
SBY: H7H31_16175(vanA)
SRIM: CP984_39910(vanA)
SSPB: CP982_31320(vanA-Sc)
SROI: IAG44_39585(vanA-Sc)
SSPN: LXH13_34735(vanA-Sc)
SCOA: QU709_45505(vanA-Sc)
STRZ: OYE22_15920(vanA)
YIA: LO772_06590(vanA)
RTX: TI83_01670(vanB)
RTC: APU90_04820(vanB)
RTN: A6122_0299
RRY: C1O28_00080(vanA)
RIA: C7V51_10855(vanA)
AGG: C1N71_08265
ASUN: KG104_11150
NARO: CFH99_00255(vanB)
KFL: Kfla_3620
KQI: F1D05_26435(vanA)
KSL: OG809_31005(vanA)
ACTW: F7P10_09890(vanA)
SPIQ: OHA34_26520(vanO)
FRE: Franean1_7137
AMD: AMED_8289(ddlA)
AMN: RAM_42565(vanB)
AMM: AMES_8162(ddlA)
AMZ: B737_8163(ddlA)
AOI: AORI_1472(ddl)
AJA: AJAP_32170
AMYC: CU254_05730(vanB)
AMYB: BKN51_41395(vanB)
AAB: A4R43_21435(vanB)
AMYY: YIM_36535(vanB)
AORI: SD37_33760(vanB)
APRT: MUY14_04915
ATHM: L1857_33140(vanA-Sc)
AMOG: QRX60_03785(vanA)
SESP: BN6_49760
SSYI: EKG83_05355(vanA)
KAL: KALB_1172
KUT: JJ691_70650(ddlA_1)
KBU: Q4V64_46365(vanA-Sc)
KPHY: AOZ06_08680(vanB) AOZ06_28865(vanB)
ACTU: Actkin_02323(vanB)
CROS: N8J89_03400(vanA)
AOU: ACTOB_006505(vanA)
PSUU: Psuf_054820
ATL: Athai_15820
ASER: Asera_58740
DVC: Dvina_26165(vanA)
DMAT: Dmats_21695(vanA)
CAI: Caci_5793
SNA: Snas_5356
GLY: K3N28_22515(vanA)
CWO: Cwoe_1414
IAM: HC251_07060
DHI: LH044_08545(vanA)
KBS: EPA93_09965(vanA)
KBB: ccbrp13_15920(vanB)
AG: CAA40215(vanA)
 » show all
Reference
PMID:7957913
  Authors
Meziane-Cherif D, Badet-Denisot MA, Evers S, Courvalin P, Badet B
  Title
Purification and characterization of the VanB ligase associated with type B vancomycin resistance in Enterococcus faecalis V583.
  Journal
FEBS Lett 354:140-2 (1994)
DOI:10.1016/0014-5793(94)01096-X
  Sequence
[efa:EF2294]
Reference
PMID:8631706
  Authors
Evers S, Courvalin P
  Title
Regulation of VanB-type vancomycin resistance gene expression by the VanS(B)-VanR (B) two-component regulatory system in Enterococcus faecalis V583.
  Journal
J Bacteriol 178:1302-9 (1996)
DOI:10.1128/JB.178.5.1302-1309.1996
  Sequence
[efa:EF2294]
Reference
PMID:15130128
  Authors
Hong HJ, Hutchings MI, Neu JM, Wright GD, Paget MS, Buttner MJ
  Title
Characterization of an inducible vancomycin resistance system in Streptomyces coelicolor reveals a novel gene (vanK) required for drug resistance.
  Journal
Mol Microbiol 52:1107-21 (2004)
DOI:10.1111/j.1365-2958.2004.04032.x
  Sequence
[sco:SCO3595]
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