KEGG   ORTHOLOGY: K15972
Entry
K15972                      KO                                     
Symbol
tcmG, elmG
Name
tetracenomycin A2 monooxygenase-dioxygenase [EC:1.14.13.200]
Pathway
map01057  Biosynthesis of type II polyketide products
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00783  Tetracenomycin C/8-demethyltetracenomycin C biosynthesis, tetracenomycin F2 => tetracenomycin C/8-demethyltetracenomycin C
Reaction
R06704  tetracenomycin-A2,NADPH:oxygen oxidoreductase (tetracenomycin-C-forming)
R10954  tetracenomycin-B2,NADPH:oxygen oxidoreductase (8-demethyltetracenomycin-C-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15972  tcmG, elmG; tetracenomycin A2 monooxygenase-dioxygenase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K15972  tcmG, elmG; tetracenomycin A2 monooxygenase-dioxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.200  tetracenomycin A2 monooxygenase-dioxygenase
     K15972  tcmG, elmG; tetracenomycin A2 monooxygenase-dioxygenase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Oxygenase
   K15972  tcmG, elmG; tetracenomycin A2 monooxygenase-dioxygenase
Other DBs
COG: COG0654
Genes
SMOR: LHA26_18465
MSPG: F6B93_10335
NYA: LTV02_15905
SGU: SGLAU_26335(tcmG)
SHUN: DWB77_06590(dnrF)
NCX: Nocox_12825(tfdB2)
ACYN: ORV05_16770
CROS: N8J89_07320
ACTY: OG774_06650
AG: CAP12596(elmG)
Reference
PMID:8509339
  Authors
Decker H, Motamedi H, Hutchinson CR
  Title
Nucleotide sequences and heterologous expression of tcmG and tcmP, biosynthetic genes for tetracenomycin C in Streptomyces glaucescens.
  Journal
J Bacteriol 175:3876-86 (1993)
DOI:10.1128/JB.175.12.3876-3886.1993
  Sequence
[sgu:SGLAU_26335]
Reference
PMID:11009387
  Authors
Rafanan ER Jr, Hutchinson CR, Shen B
  Title
Triple hydroxylation of tetracenomycin A2 to tetracenomycin C involving two molecules of O(2) and one molecule of H(2)O.
  Journal
Org Lett 2:3225-7 (2000)
DOI:10.1021/ol0002267
Reference
PMID:11325225
  Authors
Rafanan ER Jr, Le L, Zhao L, Decker H, Shen B
  Title
Cloning, sequencing, and heterologous expression of the elmGHIJ genes involved in the biosynthesis of the polyketide antibiotic elloramycin from Streptomyces olivaceus Tu2353.
  Journal
J Nat Prod 64:444-9 (2001)
DOI:10.1021/np010007+
  Sequence
[ag:CAP12596]
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