KEGG   ORTHOLOGY: K19436
Entry
K19436                      KO                                     
Symbol
ICP0, RL2
Name
Simplexvirus E3 ubiquitin-protein ligase ICP0
Pathway
map05168  Herpes simplex virus 1 infection
Network
nt06168  Herpes simplex virus 1 (HSV-1)
nt06517  TLR signaling
nt06520  CGAS-STING signaling
nt06524  Apoptosis
  Element
N00561  HSV ICP0 to TLR2/4-NFKB signaling pathway
N00570  HSV ICP0 to cGAS-STING signaling pathway
N00580  HSV ICP0 to crosstalk between extrinsic and intrinsic apoptotic pathways
N00588  HSV VP16 to Oct-1-mediated transcription
N00592  HSV ICP0 to p53-mediated transcription
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    K19436  ICP0, RL2; Simplexvirus E3 ubiquitin-protein ligase ICP0
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K19436  ICP0, RL2; Simplexvirus E3 ubiquitin-protein ligase ICP0
Viral proteins [BR:ko03200]
 dsDNA viruses
  Human herpes simplex virus 1/2
   K19436  ICP0, RL2; Simplexvirus E3 ubiquitin-protein ligase ICP0
Genes
VG: 1487288(RL2) 1487289(RL2) 1487469(RL2) 1487480(RL2) 18533891(RL2) 18533950(RL2) 2703389(RL2) 2703390(RL2) 3190344(RL2) 3190348(RL2) 3850209(RL2) 3850211(RL2)
Reference
PMID:20075863
  Authors
Lilley CE, Chaurushiya MS, Boutell C, Landry S, Suh J, Panier S, Everett RD, Stewart GS, Durocher D, Weitzman MD
  Title
A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses.
  Journal
EMBO J 29:943-55 (2010)
DOI:10.1038/emboj.2009.400
  Sequence
[vg:2703390]
LinkDB

KEGG   ORTHOLOGY: K19445
Entry
K19445                      KO                                     
Symbol
ICP4, RS1
Name
Simplexvirus major viral transcription factor ICP4
Pathway
map05168  Herpes simplex virus 1 infection
Network
nt06168  Herpes simplex virus 1 (HSV-1)
  Element
N00588  HSV VP16 to Oct-1-mediated transcription
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    K19445  ICP4, RS1; Simplexvirus major viral transcription factor ICP4
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K19445  ICP4, RS1; Simplexvirus major viral transcription factor ICP4
Viral proteins [BR:ko03200]
 dsDNA viruses
  Human herpes simplex virus 1/2
   K19445  ICP4, RS1; Simplexvirus major viral transcription factor ICP4
Genes
VG: 1487290(RS1) 1487291(RS1) 1487453(RS1) 1487467(RS1) 18533952(RS1) 18533966(RS1) 19621648(RS1) 19621717(RS1) 2703391(RS1) 2703392(RS1) 3190317(RS1) 3190328(RS1) 3850190(RS1) 3850210(RS1) 9829359(RS1) 9829370(RS1)
Reference
PMID:1846804
  Authors
Papavassiliou AG, Wilcox KW, Silverstein SJ
  Title
The interaction of ICP4 with cell/infected-cell factors and its state of phosphorylation modulate differential recognition of leader sequences in herpes simplex virus DNA.
  Journal
EMBO J 10:397-406 (1991)
DOI:10.1002/j.1460-2075.1991.tb07961.x
  Sequence
[vg:2703392]
LinkDB

KEGG   ORTHOLOGY: K19441
Entry
K19441                      KO                                     
Symbol
US1
Name
Simplexvirus transcriptional regulator ICP22
Pathway
map05168  Herpes simplex virus 1 infection
Network
nt06168  Herpes simplex virus 1 (HSV-1)
  Element
N00588  HSV VP16 to Oct-1-mediated transcription
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    K19441  US1; Simplexvirus transcriptional regulator ICP22
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K19441  US1; Simplexvirus transcriptional regulator ICP22
Viral proteins [BR:ko03200]
 dsDNA viruses
  Human herpes simplex virus 1/2
   K19441  US1; Simplexvirus transcriptional regulator ICP22
Genes
VG: 1487350(US1) 1487454(US1) 18533953(US1) 19621651(US1) 2703435(US1) 3190318(US1) 3850191(US1)
Reference
PMID:16571817
  Authors
Orlando JS, Astor TL, Rundle SA, Schaffer PA
  Title
The products of the herpes simplex virus type 1 immediate-early US1/US1.5 genes downregulate levels of S-phase-specific cyclins and facilitate virus replication in S-phase Vero cells.
  Journal
J Virol 80:4005-16 (2006)
DOI:10.1128/JVI.80.8.4005-4016.2006
  Sequence
[vg:2703435]
LinkDB

KEGG   ORTHOLOGY: K19443
Entry
K19443                      KO                                     
Symbol
UL54
Name
Simplexvirus mRNA export factor
Pathway
map05168  Herpes simplex virus 1 infection
Network
nt06168  Herpes simplex virus 1 (HSV-1)
nt06517  TLR signaling
  Element
N00575  HSV ICP27 to IFN signaling pathway
N00587  HSV ICP27 to Nuclear export of mRNA
N00588  HSV VP16 to Oct-1-mediated transcription
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    K19443  UL54; Simplexvirus mRNA export factor
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K19443  UL54; Simplexvirus mRNA export factor
Viral proteins [BR:ko03200]
 dsDNA viruses
  Human herpes simplex virus 1/2
   K19443  UL54; Simplexvirus mRNA export factor
Genes
VG: 1487343(UL54) 1487450(UL54) 18533947(UL54) 19621701(UL54) 24271474(UL54) 26828084(UL54) 26887610(UL69) 3190364(UL54) 32707781(UL54) 3850206(UL54) 9829303(UL54)
Reference
PMID:9512520
  Authors
Sandri-Goldin RM
  Title
ICP27 mediates HSV RNA export by shuttling through a leucine-rich nuclear export signal and binding viral intronless RNAs through an RGG motif.
  Journal
Genes Dev 12:868-79 (1998)
DOI:10.1101/gad.12.6.868
  Sequence
[vg:24271474]
Reference
PMID:26062451
  Authors
Tunnicliffe RB, Schacht M, Levy C, Jowitt TA, Sandri-Goldin RM, Golovanov AP
  Title
The structure of the folded domain from the signature multifunctional protein ICP27 from herpes simplex virus-1 reveals an intertwined dimer.
  Journal
Sci Rep 5:11234 (2015)
DOI:10.1038/srep11234
  Sequence
[vg:24271474]
LinkDB

KEGG   ORTHOLOGY: K19446
Entry
K19446                      KO                                     
Symbol
US12
Name
Simplexvirus ICP47 protein
Pathway
map03266  Virion - Herpesvirus
map05168  Herpes simplex virus 1 infection
Network
nt06168  Herpes simplex virus 1 (HSV-1)
  Element
N00581  HSV ICP47 to antigen processing and presentation by MHC class I molecules
N00588  HSV VP16 to Oct-1-mediated transcription
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03266 Virion - Herpesvirus
    K19446  US12; Simplexvirus ICP47 protein
 09160 Human Diseases
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    K19446  US12; Simplexvirus ICP47 protein
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K19446  US12; Simplexvirus ICP47 protein
Viral proteins [BR:ko03200]
 dsDNA viruses
  Human herpes simplex virus 1/2
   K19446  US12; Simplexvirus ICP47 protein
Genes
VG: 1487353(US10) 1487466(US12) 18533965(US12) 2703441(US12) 3190363(US12) 3850189(US12)
Reference
PMID:8187174
  Authors
York IA, Roop C, Andrews DW, Riddell SR, Graham FL, Johnson DC
  Title
A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes.
  Journal
Cell 77:525-35 (1994)
DOI:10.1016/0092-8674(94)90215-1
  Sequence
[vg:2703441]
LinkDB

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