KEGG ORTHOLOGY: K20421

ORTHOLOGY: K20421

Entry

K20421                      KO

Symbol

ncsB1

Name

2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase [EC:2.1.1.303]

Pathway

map01059

Biosynthesis of enediyne antibiotics

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00830

Neocarzinostatin naphthoate moiety biosynthesis, malonyl-CoA => 2-hydroxy-5-methyl-1-naphthoate => 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA

Reaction

R10963

S-adenosyl-L-methionine:2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K20421  ncsB1; 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K20421  ncsB1; 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.303  2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase
     K20421  ncsB1; 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase
Polyketide biosynthesis proteins [BR:ko01008]
Polyketide tailoring proteins
  Methylase
   K20421  ncsB1; 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase

Genes

CLIA:

C3E79_07185

NCY:	NOCYR_3137(dnrK)

NNO:	NONO_c58190

NTP:	CRH09_14165 CRH09_23690 CRH09_25100 CRH09_33960

NOD:	FOH10_15005 FOH10_16430

NAH:	F5544_21445

NIE:	KV110_22915

NHU:	H0264_26770

NSPU:

IFM12276_29470

RHU:	A3Q40_00430(rdmB)

DTM:	BJL86_2741

SMA:	SAVERM_2382

SSX:	SACTE_5196 SACTE_6329

SHY:	SHJG_8512 SHJG_8515

SHO:	SHJGH_8272 SHJGH_8275

SSOI:

I1A49_00935

SCW:	TU94_01395

SXI:	SXIM_36010

SPRI:

SPRI_3765

SLE:	sle_66100(sle_66100)

SPHW:

NFX46_33070

SLS:	SLINC_1337 SLINC_5831

SALU:

DC74_6556

SALL:

SAZ_34135

SAUO:

BV401_01185

SGV:	B1H19_02505

STIR:

DDW44_27895

SKA:	CP970_39755

SGZ:	C0216_12105

SGAL:

SRIM:

SCIN:

STSU:

SCOE:

STUI:

SCHF:

SFEU:

SROI:

SDD:	D9753_27325

STAA:

LDH80_10680

SROC:

RGF97_06890

MIH:	BJP65_10025

SKE:	Sked_14480

CELZ:

E5225_16810

NRO:	K8W59_02610

KFL:

Kfla_6058

KQI:	F1D05_14965

NAL:	B005_2465(dnrK)

NEX:	NE857_03915

AMAZ:

LUW76_34080

NOA:	BKM31_13620 BKM31_42290

SEN:

SACE_4650

SACG:

FDZ84_19175 FDZ84_28800 FDZ84_37280

AMD:

AMN:

AMM:

AMZ:

AOI:

AJA:	AJAP_06605

AMYC:

CU254_34420

AMYB:

BKN51_25805

AAB:	A4R43_20175

AMYY:

YIM_09465(dnrK1) YIM_15125(dnrK2)

AORI:

SD37_05090 SD37_08075

APRT:

AROO:

ARHD:

PDX:

PSEE:

FRP1_29540 FRP1_30105

PECQ:

AD017_32745 AD017_33050

PHH:	AFB00_04185 AFB00_16770

PBRO:

APRE:

AMI:

SESP:

SSYI:

EKG83_21075 EKG83_31050

KUT:	JJ691_03700

KPHY:

AOZ06_09075

LED:	BBK82_29280

AHM:	TL08_06695

ACTI:

UA75_06455

ACAD:

UA74_06455

AHG:	AHOG_06225(dnrK1)

PMAD:

BAY61_07660 BAY61_19805

SACE:

GIY23_05190

CROS:

N8J89_23865 N8J89_31400

UME:	RM788_47835

STP:	Strop_2214

SAQ:

Sare_4955

MAU:	Micau_3716

MIL:

MICB:

MICH:

MCHL:

MFEU:

MPRN:

AMS:	AMIS_34740

PRY:	Prubr_63830

DVC:	Dvina_22655

NHY:	JQS43_20915

CCAZ:

COUCH_30655

KBS:	EPA93_15280

KBB:	ccbrp13_13680

SUS:

Acid_5654

PFER:

IRI77_02260

AG:	AAM77984(ncsB1)

» show all

Reference

PMID:18387946

Authors

Luo Y, Lin S, Zhang J, Cooke HA, Bruner SD, Shen B

Title

Regiospecific O-methylation of naphthoic acids catalyzed by NcsB1, an O-methyltransferase involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin.

Journal

J Biol Chem 283:14694-702 (2008)
DOI:10.1074/jbc.M802206200

Sequence

[ag:AAM77984]

LinkDB

DBGET integrated database retrieval system