Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces

Liu W, Nonaka K, Nie L, Zhang J, Christenson SD, Bae J, Van Lanen SG, Zazopoulos E, Farnet CM, Yang CF, Shen B

The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases.

Chem Biol 12:293-302 (2005)
DOI:10.1016/j.chembiol.2004.12.013

Luo Y, Lin S, Zhang J, Cooke HA, Bruner SD, Shen B

Regiospecific O-methylation of naphthoic acids catalyzed by NcsB1, an O-methyltransferase involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin.

J Biol Chem 283:14694-702 (2008)
DOI:10.1074/jbc.M802206200

Cooke HA, Guenther EL, Luo Y, Shen B, Bruner SD

Molecular basis of substrate promiscuity for the SAM-dependent O-methyltransferase NcsB1, involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin.

Biochemistry 48:9590-8 (2009)
DOI:10.1021/bi901257q