KEGG   ORTHOLOGY: K20566
Entry
K20566            Tight     KO                                     
Symbol
kanI
Name
paromamine 6'-oxidase / 2'-deamino-2'-hydroxyparomamine 6'-oxidase [EC:1.1.3.43 1.1.3.-]
Pathway
map00524  Neomycin, kanamycin and gentamicin biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R08896  paromamine:oxygen 6'-oxidoreductase
R10207  2'-deamino-2'-hydroxyparomamine:oxygen 6'-oxidoreductase
R11267  kanamycin-X:oxygen 6'-oxidoreductase
R11268  kanamycin-C:oxygen 6'-oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00524 Neomycin, kanamycin and gentamicin biosynthesis
    K20566  kanI; paromamine 6'-oxidase / 2'-deamino-2'-hydroxyparomamine 6'-oxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.3  With oxygen as acceptor
    1.1.3.43  paromamine 6'-oxidase
     K20566  kanI; paromamine 6'-oxidase / 2'-deamino-2'-hydroxyparomamine 6'-oxidase
Other DBs
COG: COG2303
Genes
SKA: CP970_06660
AG: CAF60534(kanI)
Reference
  Authors
Kharel MK, Subba B, Basnet DB, Woo JS, Lee HC, Liou K, Sohng JK
  Title
A gene cluster for biosynthesis of kanamycin from Streptomyces kanamyceticus: comparison with gentamicin biosynthetic gene cluster.
  Journal
Arch Biochem Biophys 429:204-14 (2004)
DOI:10.1016/j.abb.2004.06.009
  Sequence
Reference
  Authors
Park JW, Park SR, Nepal KK, Han AR, Ban YH, Yoo YJ, Kim EJ, Kim EM, Kim D, Sohng JK, Yoon YJ
  Title
Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation.
  Journal
Nat Chem Biol 7:843-52 (2011)
DOI:10.1038/nchembio.671
LinkDB

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