REACTION: R11268
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Entry
R11268 Reaction
Name
kanamycin-C:oxygen 6'-oxidoreductase
Definition
Kanamycin C + Oxygen <=> 6'-Oxokanamycin C + Hydrogen peroxide
Equation
C01823
+
C00007
<=>
C21252
+
C00027
Reaction class
RC00450
C01823_C21252
Enzyme
1.1.3.-
Pathway
rn00524
Neomycin, kanamycin and gentamicin biosynthesis
rn01110
Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:
br08201
]
1. Oxidoreductase reactions
1.1 Acting on the CH-OH group of donors
1.1.3 With oxygen as acceptor
1.1.3.-
R11268 Kanamycin C + Oxygen <=> 6'-Oxokanamycin C + Hydrogen peroxide
BRITE hierarchy
Orthology
K20566
paromamine 6'-oxidase / 2'-deamino-2'-hydroxyparomamine 6'-oxidase [EC:
1.1.3.43
1.1.3.-]
Reference
1 [PMID:
21983602
]
Authors
Park JW, Park SR, Nepal KK, Han AR, Ban YH, Yoo YJ, Kim EJ, Kim EM, Kim D, Sohng JK, Yoon YJ
Title
Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation.
Journal
Nat Chem Biol 7:843-52 (2011)
DOI:
10.1038/nchembio.671
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