KEGG ORTHOLOGY: K21418

ORTHOLOGY: K21418

Entry

K21418                      KO

Symbol

HMOX2

Name

heme oxygenase 2 [EC:1.14.14.18]

Pathway

map00860

Porphyrin metabolism

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

map04978

Mineral absorption

Reaction

R00311

protoheme,NADPH---hemoprotein reductase:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    K21418  HMOX2; heme oxygenase 2
09150 Organismal Systems
  09154 Digestive system
   04978 Mineral absorption
    K21418  HMOX2; heme oxygenase 2
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.18  heme oxygenase (biliverdin-producing)
     K21418  HMOX2; heme oxygenase 2

Other DBs

COG:

COG5398

GO:

0004392

Genes

HSA:	3163(HMOX2)

PTR:	453880(HMOX2)

PPS:	100995961(HMOX2)

GGO:	101149599(HMOX2)

PON:	100451286(HMOX2)

NLE:	100599593(HMOX2)

HMH:	116462362(HMOX2)

MCC:	705461(HMOX2)

MCF:	102143766(HMOX2)

MNI:	105467840(HMOX2)

CSAB:

103227650(HMOX2)

CATY:

105572109(HMOX2)

PANU:

101007549(HMOX2)

TGE:	112613931(HMOX2)

MLEU:

105538591(HMOX2)

RRO:	104654687(HMOX2)

RBB:	108538293(HMOX2)

TFN:	117097713(HMOX2)

PTEH:

111551702(HMOX2)

CANG:

105525633(HMOX2)

CJC:	100395145(HMOX2)

SBQ:	101053852(HMOX2)

CIMI:

108287517(HMOX2)

CSYR:

103260373(HMOX2)

MMUR:

105859706(HMOX2)

LCAT:

123632330(HMOX2)

PCOQ:

105813117(HMOX2)

OGA:	100945366(HMOX2)

MMU:	15369(Hmox2)

MCAL:

110311757(Hmox2)

MPAH:

110329550(Hmox2)

RNO:	79239(Hmox2)

MCOC:

116084296(Hmox2)

ANU:	117711075(Hmox2)

MUN:	110545942(Hmox2)

CGE:	100773727(Hmox2)

MAUA:

101844419(Hmox2)

PROB:

127219625(Hmox2)

PLEU:

114710646(Hmox2)

MORG:

121463617(Hmox2)

MFOT:

126493168

AAMP:

119811281(Hmox2)

NGI:	103744546(Hmox2)

HGL:	101718879(Hmox2)

CPOC:

100719916(Hmox2)

CCAN:

109694248(Hmox2)

DORD:

105982226(Hmox2)

DSP:	122123859(Hmox2)

PLOP:

125341185(Hmox2)

NCAR:

124970129

MMMA:

107146654(Hmox2)

OCU:	100009523(HMOX2)

OPI:	101519276(HMOX2)

TUP:	102472031(HMOX2)

GVR:	103587596(HMOX2)

CFA:	479864(HMOX2)

CLUD:

112640428(HMOX2)

VVP:	112923276(HMOX2)

VLG:	121486510(HMOX2)

NPO:	129519682(HMOX2)

AML:	100472787(HMOX2)

UMR:	103668554(HMOX2)

UAH:	113270845(HMOX2)

UAR:	123783810(HMOX2)

ELK:

111156155

LLV:

125090962

MPUF:

101674208(HMOX2)

MNP:	132026944(HMOX2)

MLK:	131819504(HMOX2) 131827899

NVS:	122895903(HMOX2)

ORO:	101367073(HMOX2)

EJU:	114219917(HMOX2)

ZCA:	113931785(HMOX2)

MLX:	118021788(HMOX2)

NSU:	110588012(HMOX2)

LWW:	102728290(HMOX2)

FCA:	101093823(HMOX2)

PYU:	121019586(HMOX2)

PCOO:

112853243(HMOX2)

PBG:	122471723(HMOX2)

PVIV:

125154254(HMOX2)

LRUF:

124517888

PTG:	102960470(HMOX2)

PPAD:

109278264(HMOX2)

PUC:

125927260

AJU:

106978811

HHV:	120236449(HMOX2)

BTA:	510243(HMOX2)

BOM:	102274047(HMOX2)

BIU:	109578491(HMOX2)

BBUB:

102408288(HMOX2)

BBIS:

104988917(HMOX2)

CHX:	102189453(HMOX2)

OAS:	101102279(HMOX2)

BTAX:

128070113(HMOX2)

ODA:	120874472(HMOX2)

CCAD:

122433493(HMOX2)

MBEZ:

129545335(HMOX2)

SSC:	396622(HMOX2)

CFR:	102503731(HMOX2)

CBAI:

105064789(HMOX2)

CDK:	105099820(HMOX2)

VPC:	102537472(HMOX2)

BACU:

103012514(HMOX2)

BMUS:

118881874(HMOX2)

LVE:	103090745(HMOX2)

OOR:	101279301(HMOX2)

DLE:	111185258(HMOX2)

PCAD:

102987384(HMOX2)

PSIU:

116740903(HMOX2)

NASI:

112409563(HMOX2)

ECB:	100066114(HMOX2)

EPZ:	103553961(HMOX2)

EAI:	106826005(HMOX2)

MYB:	102253515(HMOX2)

MYD:	102764042(HMOX2)

MMYO:

118655950(HMOX2)

MLF:	102417610(HMOX2)

PKL:	118703355(HMOX2)

EFUS:

103286146(HMOX2)

MNA:	107538275(HMOX2)

DRO:	112298373(HMOX2)

SHON:

118975814(HMOX2)

AJM:	119043852 119043853

PDIC:

114500230(HMOX2)

PHAS:

123807158(HMOX2)

MMF:	118641450(HMOX2)

PPAM:

129083654(HMOX2)

HAI:	109392113(HMOX2)

RFQ:	117019396(HMOX2)

PALE:

102882902(HMOX2)

PGIG:

120620340(HMOX2)

PVP:	105303087(HMOX2)

RAY:	107521676(HMOX2)

MJV:	108399932(HMOX2)

TOD:	119241971(HMOX2) 119245209

SARA:

101556866(HMOX2)

SETR:

126001265(HMOX2)

LAV:	100662132(HMOX2)

TMU:

101347149

ETF:	101663622(HMOX2)

DNM:	101423382(HMOX2)

MDO:	100019502(HMOX2)

GAS:	123232496(HMOX2)

SHR:	100928954(HMOX2)

AFZ:

127540062

PCW:	110202456(HMOX2)

OAA:	100078850(HMOX2)

GGA:	416663(HMOX2)

PCOC:

116230244(HMOX2)

MGP:	100541778(HMOX2)

CJO:	107320929(HMOX2)

TPAI:

128078955(HMOX2)

LMUT:

125700581(HMOX2)

NMEL:

110405969(HMOX2)

APLA:

101802288(HMOX2)

ACYG:

106033412(HMOX2)

CATA:

118249295(HMOX2)

AFUL:

116495194(HMOX2)

TGU:	100190323(HMOX2)

LSR:	110476111(HMOX2)

SCAN:

103817760(HMOX2)

PMOA:

120513305(HMOX2)

OTC:	121334380(HMOX2)

PRUF:

121350794(HMOX2)

GFR:	102032618(HMOX2)

FAB:	101817237(HMOX2)

OMA:	130259386(HMOX2)

PHI:	102104458(HMOX2)

PMAJ:

107211143(HMOX2)

CCAE:

111935886(HMOX2)

CCW:	104684958(HMOX2)

CBRC:

103620456(HMOX2)

ETL:	114057016(HMOX2)

ZAB:	102065357(HMOX2)

ACHL:

103797057(HMOX2)

SVG:	106862135(HMOX2)

MMEA:

130577213(HMOX2)

HRT:	120759505(HMOX2)

FPG:	101921302(HMOX2)

FCH:	102047339(HMOX2)

CLV:	106145636(HMOX2)

EGZ:	104121977(HMOX2)

NNI:	104023461(HMOX2)

PCRI:

104025282(HMOX2)

PLET:

104615363(HMOX2)

EHS:

104502860

PCAO:

104039672(HMOX2)

ACUN:

113485489(HMOX2)

TALA:

104361706(HMOX2)

PADL:

103917531(HMOX2)

AFOR:

103897503(HMOX2)

ACHC:

115336020(HMOX2)

HALD:

104316893(HMOX2)

HLE:	104838571(HMOX2)

AGEN:

126053332

GCL:

127022607

CCRI:

104164514(HMOX2)

CSTI:

104554774(HMOX2)

CMAC:

104487334(HMOX2)

MUI:	104533930(HMOX2)

BREG:

104633711(HMOX2)

FGA:	104077471(HMOX2)

GSTE:

104252240(HMOX2)

LDI:	104347422(HMOX2)

MNB:	103780482(HMOX2)

OHA:	104331023(HMOX2)

NNT:	104407966(HMOX2)

SHAB:

115607476(HMOX2)

DPUB:

104300273(HMOX2)

PGUU:

104458060(HMOX2)

ACAR:

104517993(HMOX2)

CPEA:

104386815(HMOX2)

AVIT:

104276478(HMOX2)

CVF:	104283721(HMOX2)

RTD:	128914313(HMOX2)

CUCA:

104068127(HMOX2)

TEO:	104379692(HMOX2)

BRHI:

104489415(HMOX2)

AAM:	106482411(HMOX2)

AROW:

112965820(HMOX2)

NPD:	112955734(HMOX2)

TGT:	104569037(HMOX2)

DNE:	112987718(HMOX2)

SCAM:

104143889(HMOX2)

ASN:	102368811(HMOX2)

AMJ:	102575746(HMOX2)

CPOO:

109313453(HMOX2)

GGN:	109290779(HMOX2)

PSS:	102446230(HMOX2)

CMY:	102942411(HMOX2)

CCAY:

125643728(HMOX2)

DCC:	119862692(HMOX2)

CPIC:

101931937(HMOX2)

TST:	117883718(HMOX2)

CABI:

116825526(HMOX2)

MRV:	120373614(HMOX2)

ASAO:

132782065(HMOX2)

PVT:	110089101(HMOX2)

SUND:

121914568(HMOX2)

PBI:	103054508(HMOX2)

PMUR:

107283999(HMOX2)

CTIG:

120315733(HMOX2)

TSR:	106556179(HMOX2)

PGUT:

117679461(HMOX2)

APRI:

131185308(HMOX2)

PTEX:

113438890(HMOX2)

NSS:	113422435(HMOX2)

VKO:	123025002(HMOX2)

PMUA:

114584030(HMOX2)

PRAF:

128401362(HMOX2)

ZVI:	118093247(HMOX2)

HCG:	128336852(HMOX2)

GJA:	107109317(HMOX2)

STOW:

125431054(HMOX2)

EMC:	129338364(HMOX2)

XLA:	444101(hmox2.S)

XTR:	780096(hmox2)

NPR:	108796525(HMOX2)

RTEM:

120943138(HMOX2)

BBUF:

121007432(HMOX2)

BGAR:

122945021(HMOX2)

MUO:	115475556(HMOX2) 115475558

GSH:	117345657(HMOX2)

DRE:	100002875(hmox2a) 100329531(hmox2b)

SRX:	107718627 107735607 107742095 107742125

SANH:

107659301 107678258 107695708

SGH:	107553648 107566667 107601585

CCAR:

109056068 109087524

CAUA:

113039962 113051676 113067443 113067737

CGIB:

127952800 127955603 127988305

PTET:

122327682(hmox2a) 122340972(hmox2b)

LROH:

127153470(hmox2a) 127163346(hmox2b)

OMC:	131530858(hmox2a) 131536334(hmox2b)

PPRM:

120489531(hmox2b) 120495390(hmox2a)

RKG:	130095091(hmox2b) 130103536(hmox2a)

MAMB:

125263707(hmox2a) 125275144(hmox2b)

CIDE:

127509470 127509471 127520681

MASI:

127438529 127438955 127449752 127452005

TROS:

130549016(hmox2a) 130560990(hmox2b)

TDW:	130426705(hmox2b) 130430597(hmox2a)

MANU:

129436650(hmox2b) 129453693(hmox2a)

IPU:	108276515(hmox2b)

IFU:	128625062(hmox2b)

PHYP:

113528023(hmox2)

SMEO:

124396696(hmox2b)

TFD:	113639549(hmox2b)

TVC:	132860610(hmox2b)

TRN:	134335807 134336214

AMEX:

103032679(hmox2) 107197269

CMAO:

118804585(hmox2a) 118821429(hmox2b)

EEE:	113576792(hmox2) 113580696

CHAR:

105910101(hmox2b)

TRU:	101074254(hmox2)

TFS:	130514859(hmox2b)

TNG:	GSTEN00018521G001

LCO:	104922039 104925696

NCC:	104960161(hmox2) 104965605

TBEN:

117474598(hmox2a) 117492318(hmox2b)

CGOB:

115010681 115012099

PGEO:

117450908(hmox2b) 117453713(hmox2a)

GACU:

117548358(hmox2b) 117561763(hmox2a)

EMAC:

134864903(hmox2a) 134877762(hmox2b)

ELY:	117254792(hmox2a) 117268981(hmox2b)

EFO:	125879018(hmox2b) 125886257(hmox2a)

PLEP:

121942351(hmox2a) 121956313(hmox2b)

SLUC:

116059383(hmox2b)

ECRA:

117958131(hmox2b)

ESP:	116702858(hmox2)

PFLV:

114570096(hmox2)

GAT:	120827581(hmox2b)

PPUG:

119219954(hmox2b)

AFB:	129098042(hmox2b)

CLUM:

117734845(hmox2b)

PSWI:

130188856(hmox2b)

MSAM:

119889868 119911190

SCHU:

122869383(hmox2b) 122874115(hmox2a)

CUD:	121503487(hmox2b) 121507955(hmox2a)

ALAT:

119014439(hmox2b) 119021479(hmox2a)

MZE:	101468730 101479559

ONL:	100700023 100705244

OAU:	116310603(hmox2a) 116321440(hmox2b)

OLA:	101163641 101175163

OML:	112137078(hmox2a) 112146201(hmox2b)

CSAI:

133422481(hmox2b) 133444100(hmox2a)

XMA:	102220354 102228740

XCO:	114144847 114159454

XHE:	116720147 116735228

PRET:

103460601 103464485

PFOR:

103131038 103131039 103132347 103132348 103140996

PLAI:

106942499 106945955 106945958

PMEI:

106912146 106912148 106915770 106933945 106933949

GAF:	122821774(hmox2b) 122829733(hmox2a)

PPRL:

129363582(hmox2b) 129366947

CVG:	107081012 107083183(hmox2) 107083418

CTUL:

119773193(hmox2b) 119787495 119787508

GMU:	124862745 124864803 124868489 124868760

NFU:	107376482(hmox2)

KMR:	108241505(hmox2a) 108247647(hmox2b)

ALIM:

106518701 106532467

NWH:	119420993(hmox2b) 119423129

AOCE:

111567707 111569915

MCEP:

124998004(hmox2b) 125001369(hmox2a)

CSEM:

103393059(hmox2)

POV:	109627342 109638714(hmox2)

SSEN:

122785804(hmox2b)

HHIP:

117766538(hmox2b)

HSP:	118123210(hmox2b)

PPLT:

128458635(hmox2b)

SMAU:

118288902(hmox2b)

LCF:	108885403 108886150(hmox2b)

SDU:	111227028(hmox2) 111229233

SLAL:

111657765 111665523

XGL:	120788230(hmox2b) 120799982(hmox2a)

HCQ:	109519933 109521440(hmox2)

SSCV:

125983887

SBIA:

133515059(hmox2b)

PEE:	133414827(hmox2b)

PTAO:

133466583(hmox2b)

BPEC:

110167460(hmox2)

MALB:

109972913(hmox2)

BSPL:

114860709(hmox2b)

SJO:	128379024(hmox2b) 128379372

SASA:

106564458 106601841 106601881 106606500

STRU:

115171780 115206533

OTW:	112226265(hmox2b)

OMY:	110487001(hmox2b) 110512532

OGO:	124000693(hmox2b)

ONE:

115118606

OKI:

109877356

OKE:	118382637(hmox2b)

SALP:

112075189 112077284

SNH:	120027870(hmox2a) 120044830 120044836

CCLU:

121551250 121551539 121553874(hmox2a)

ELS:

105006006

SFM:	108928847(hmox2)

PKI:	111843261(hmox2)

AANG:

118217026(hmox2b)

LOC:	102694370(hmox2)

PSPA:

121301471 121330934

ARUT:

117418388(hmox2b) 117973711

PSEX:

120542012(hmox2b)

LCM:	102360501(HMOX2)

CMK:

RTP:

CPLA:

HOC:

LERI:

PMRN:

116951392 116951419(HMOX2)

LRJ:	133340629 133340632

CIN:

100185311

DME:	Dmel_CG14716(Ho)

DER:

6553971

DSE:

6606790

DSI:	Dsimw501_GD18775(Dsim_GD18775)

DYA:	Dyak_GE24194

DAN:

DSR:

DPO:

DPE:

DMN:	108155228 108162343

DWI:

6647136

DGR:

6563557

DMO:	Dmoj_GI24074

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ007246

CPII:

120420937 120431345

CNS:

116351927

BCOO:

119076867

AME:	494506(Ho)

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

CFO:

FEX:	115237904 115237905

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:	100115195(Ho)

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

VCAN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

BMOR:

BMAN:

MSEX:

DPL:	KGM_210306

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:	105384832 105394329

PGW:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

NLU:	111056053 120348808

HVI:	124365751 124370983

MQU:	128982601 129003167

PHU:	Phum_PHUM417690

FOC:

TPAL:

ZNE:

CSEC:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_222567

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

TCF:

PPOI:

HRO:	HELRODRAFT_70990

LGI:	LOTGIDRAFT_172621

PCAN:

112563525 112563526 112571138

HRF:

124120013

HRJ:

124252831

ATEN:

116298139

XEN:	124439942 124445479

VG:	10327123(PHM1_210) 10328080(PHM2_209) 10328866(SSSM7_301) 10328868(SSSM7_303) 15010407(CPMG_00138) 15011641(CPXG_00029)

» show all

Reference

PMID:7890772

Authors

Ishikawa K, Takeuchi N, Takahashi S, Matera KM, Sato M, Shibahara S, Rousseau DL, Ikeda-Saito M, Yoshida T

Title

Heme oxygenase-2. Properties of the heme complex of the purified tryptic fragment of recombinant human heme oxygenase-2.

Journal

J Biol Chem 270:6345-50 (1995)
DOI:10.1074/jbc.270.11.6345

Sequence

[hsa:3163]

LinkDB

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