KEGG   REACTION: R00311
Entry
R00311                      Reaction                               
Name
protoheme,NADPH---hemoprotein reductase:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating)
Definition
Heme + 3 [Reduced NADPH---hemoprotein reductase] + 3 Oxygen <=> Biliverdin + CO + Fe2+ + 3 [Oxidized NADPH---hemoprotein reductase] + 3 H2O
Equation
C00032 + 3 C03024 + 3 C00007 <=> C00500 + C00237 + C14818 + 3 C03161 + 3 C00001
Comment
multi-step reaction
Reaction class
RC01270  C00032_C00500
Enzyme
1.14.14.18
Pathway
rn00860  Porphyrin metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.18
     R00311  Heme + 3 [Reduced NADPH---hemoprotein reductase] + 3 Oxygen <=> Biliverdin + CO + Fe2+ + 3 [Oxidized NADPH---hemoprotein reductase] + 3 H2O
Orthology
K00510  heme oxygenase 1 [EC:1.14.14.18]
K21418  heme oxygenase 2 [EC:1.14.14.18]
Other DBs
RHEA: 21767
LinkDB

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