KEGG ORTHOLOGY: K23146

KEGG

ORTHOLOGY: K23146

Entry

K23146                      KO

Symbol

HPD1

Name

3-hydroxyisobutyrate/3-hydroxypropionate dehydrogenase [EC:1.1.1.31 1.1.1.59]

Pathway

Valine, leucine and isoleucine degradation

beta-Alanine metabolism

Propanoate metabolism

Metabolic pathways

Carbon metabolism

Module

Malonate semialdehyde pathway, propanoyl-CoA => acetyl-CoA

Reaction

3-hydroxypropanoate:NAD+ oxidoreductase

3-hydroxy-2-methylpropanoate:NAD+ oxidoreductase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09101 Carbohydrate metabolism
   00640 Propanoate metabolism
    K23146  HPD1; 3-hydroxyisobutyrate/3-hydroxypropionate dehydrogenase
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    K23146  HPD1; 3-hydroxyisobutyrate/3-hydroxypropionate dehydrogenase
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    K23146  HPD1; 3-hydroxyisobutyrate/3-hydroxypropionate dehydrogenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.31  3-hydroxyisobutyrate dehydrogenase
     K23146  HPD1; 3-hydroxyisobutyrate/3-hydroxypropionate dehydrogenase
    1.1.1.59  3-hydroxypropionate dehydrogenase
     K23146  HPD1; 3-hydroxyisobutyrate/3-hydroxypropionate dehydrogenase

Other DBs

COG:

GO:	0008442 0047565

Genes

DME:	Dmel_CG15093(CG15093)

DER:

DSE:

DSI:	Dsimw501_GD25359(Dsim_GD25359)

DYA:	Dyak_GE13884

DSR:	110178468 110178492

DPO:

DPE:

DMN:	108160705 117191284

DWI:

DGR:

DMO:	Dmoj_GI20341

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

AOQ:

TDA:	119662924 119682817 119683689

MDE:	101898222 131803904

SCAC:

LCQ:

LSQ:

GFS:	119644386 119644388

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

109417854 109426815

CQU:	CpipJ_CPIJ015209

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

116160241 116160242

OTU:

BMOR:

100174823(hibadh)

BMAN:

MSEX:

DPL:	KGM_210828

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

CFEL:

CCRN:

BTAB:

NLU:

ATH:

ALY:

CRB:

CSAT:

104718244 104722970 104731464

EUS:	EUTSA_v10025955mg

BRP:

BNA:	106360992 106427509 125594720

BOE:

RSZ:

THJ:

CPAP:

CIT:

CIC:	CICLE_v10015754mg

PVY:

MINC:

123205321 123227250

TCC:

GRA:

GHI:	107910663 121217706

GAB:

HSYR:

DZI:

EGR:

GMX:	100798272 100814043

GSJ:	114367182 114386757

PVU:	PHAVU_006G127500g

VRA:

VAR:

VUN:

VUM:

CCAJ:

APRC:

MTR:

TPRA:

CAM:

PSAT:

VVO:	131622450 131636135

LJA:	Lj6g3v1629990.1(Lj6g3v1629990.1)

ADU:

AIP:

AHF:	112741474 112796184

LANG:

PCIN:

QSA:	O6P43_001644 O6P43_032198

FVE:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:

MSYL:

PXB:

ZJU:

MNT:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

JCU:

HBR:

MESC:

POP:

PEU:

PALZ:

JRE:

CILL:

CAVE:

132168528 132172734

QSU:	112006083 112035417

QLO:

TWL:

VVI:

VRI:

SLY:

SPEN:

SOT:

SSTN:

SDUL:

CANN:

LBB:

NTA:	107778120 107813802

NSY:

NTO:

NAU:

INI:

ITR:

SIND:

OEU:

EGT:

SSPL:

SMIL:

SHIS:

APAN:

HAN:

ECAD:

LSV:

CCAV:

DCR:

CSIN:

RVL:

AEW:

BVG:

CQI:	110702117 110728509

ATRI:

MOF:

NNU:

MING:

TSS:

PSOM:

113278796 113290220

OSA:

DOSA:

Os06t0677400-01(Os06g0677400)

OBR:

OGL:

BDI:

ATS:

TDC:	119332183 119339986

TAES:

123154424 123159992 123167292

TUA:

LPER:

LRD:

SBI:

ZMA:

SITA:

SVS:

PVIR:

120668435 120704217

PHAI:

PDA:

EGU:

MUS:

ZOF:	121992046 122039001

DCT:

PEQ:

AOF:

MSIN:

NCOL:

ATR:

PPP:

VCN:	VOLCADRAFT_118095

MNG:

CSL:	COCSUDRAFT_17252

APRO:

DHA:	DEHA2A06116g

PIC:	PICST_35865(HIB1)

PGU:	PGUG_03513

SPAA:

SPAPADRAFT_63316

LEL:	PVL30_005646

CAL:	CAALFM_C602890CA(HPD1)

CTP:	CTRG_05388

COT:	CORT_0F02180

CDU:	CD36_63190

YLI:	YALI0F02607g

CLU:	CLUG_05312

CLUS:

CAUR:

SLB:	AWJ20_3507

NCR:

NTE:	NEUTE1DRAFT145029(NEUTE1DRAFT_145029)

SMP:	SMAC_04681

PAN:	PODANS72p054 PODANSg166 PODANSg171

PBEL:

QC761_001090 QC761_001140 QC761_608640

PPSD:

QC762_001090 QC762_001140 QC762_608640

PPSP:

QC763_001090 QC763_001140 QC763_608640

PPSA:

QC764_001090 QC764_001140 QC764_608640

TTT:	THITE_2114362

MTM:	MYCTH_2310492

CTHR:

MGR:

PPEI:

PGRI:

TMN:	UCRPA7_2168 UCRPA7_8112

SSCK:

SPSK_05342 SPSK_07755

FGR:	FGSG_05284

FPU:	FPSE_07208

FPOA:

FVN:	FVRRES_04544 FVRRES_08081 FVRRES_08977

FVR:	FVEG_06255

FOX:	FOXG_08423 FOXG_10918 FOXG_12981 FOXG_13122

NHE:	NECHADRAFT_33071 NECHADRAFT_86141 NECHADRAFT_86146 NECHADRAFT_93927 NECHADRAFT_93929 NECHADRAFT_97103 NECHADRAFT_97778

FFC:	NCS54_00232100 NCS54_00749000 NCS54_00924800 NCS54_01286600 NCS54_01287100 NCS54_01294200 NCS54_01299400 NCS54_01435700

FKR:	NCS57_00227500 NCS57_00790000 NCS57_00941000 NCS57_01277400 NCS57_01277900 NCS57_01285100 NCS57_01418500

FMU:	J7337_004529

TRE:	TRIREDRAFT_104140

TRR:	M419DRAFT_73258

MAW:

MAJ:

PCHM:

CMT:

AMUS:

PLJ:	VFPFJ_06557 VFPFJ_10197

PTKZ:

JDV02_000005 JDV02_008842 JDV02_008843

VAL:	VDBG_01344

VDA:	VDAG_07909

CFJ:	CFIO01_03841 CFIO01_11654 CFIO01_11658

CLUP:

CHIG:

SAPO:

ELA:	UCREL1_3303 UCREL1_4347 UCREL1_4352

PFY:	PFICI_05450 PFICI_07605 PFICI_07606

SSL:	SS1G_08367

BFU:	BCIN_12g03570

MBE:	MBM_02485 MBM_02490 MBM_03263

PSCO:

LY89DRAFT_617415 LY89DRAFT_651541 LY89DRAFT_654964 LY89DRAFT_723046

GLZ:	GLAREA_01875

ANI:	ANIA_00593

AFM:	AFUA_3G09470 AFUA_6G11020

ACT:	ACLA_084700

AOR:	AO090023000518

ANG:	An08g07890

AFV:	AFLA_006864

ALUC:

ACHE:

APUU:

APUU_10023S APUU_11491S APUU_41425A APUU_51405A APUU_51521A APUU_51526A APUU_60770S APUU_61096S APUU_61099A APUU_61270S

PCS:	N7525_005050 N7525_006434

PDP:	PDIP_24820 PDIP_39320

POU:	POX_d04818

TMF:	EYB26_001108 EYB26_006771 EYB26_006775 EYB26_008423

TRG:	TRUGW13939_00127 TRUGW13939_00885 TRUGW13939_00890 TRUGW13939_03164 TRUGW13939_03169

CIM:	CIMG_00035 CIMG_02428

CPW:	CPC735_040550 CPC735_060780

URE:	UREG_00163 UREG_03280

PBL:	PAAG_03978

PBN:	PADG_03466

ABE:

TVE:

AJE:	HCAG_01093

BGH:	BDBG_06544

PNO:	SNOG_04145 SNOG_05709 SNOG_05712 SNOG_08720

PTE:	PTT_14929 PTT_17331 PTT_18754

BZE:	COCCADRAFT_23970 COCCADRAFT_30161 COCCADRAFT_35760 COCCADRAFT_38644

BSC:	COCSADRAFT_132068 COCSADRAFT_144678 COCSADRAFT_168276 COCSADRAFT_217719

BOR:	COCMIDRAFT_81061 COCMIDRAFT_98672 COCMIDRAFT_9903 COCMIDRAFT_99274

AALT:

CC77DRAFT_1020606 CC77DRAFT_1046659 CC77DRAFT_317829 CC77DRAFT_971877

ARAB:

EKO05_0009131 EKO05_0010478

ZTR:	MYCGRDRAFT_110793 MYCGRDRAFT_48355

PFJ:	MYCFIDRAFT_154262 MYCFIDRAFT_185924 MYCFIDRAFT_211096 MYCFIDRAFT_56858 MYCFIDRAFT_83007

FFU:	CLAFUR5_02691 CLAFUR5_03009 CLAFUR5_11198

CBET:

CB0940_07217 CB0940_09191

BCOM:

BAUCODRAFT_39046 BAUCODRAFT_70484

NPA:	UCRNP2_10215 UCRNP2_6635

TML:	GSTUM_00004370001

CCAC:

CcaHIS019_0108550(CcaverHIS019_0108550)

SHS:	STEHIDRAFT_59594

ADL:	AURDEDRAFT_89096

FME:	FOMMEDRAFT_107760 FOMMEDRAFT_118118 FOMMEDRAFT_17459

ABP:	AGABI1DRAFT116631(AGABI1DRAFT_116631)

ABV:	AGABI2DRAFT196100(AGABI2DRAFT_196100)

PCUB:

MRR:	Moror_17718

MORE:

PTRC:

PSTR:

Pst134EA_021434

Reference

Authors

Otzen C, Bardl B, Jacobsen ID, Nett M, Brock M

Title

Candida albicans utilizes a modified beta-oxidation pathway for the degradation of toxic propionyl-CoA.

Journal

J Biol Chem 289:8151-69 (2014)
DOI:10.1074/jbc.M113.517672

Sequence

[cal:CAALFM_C602890CA]

LinkDB

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