KEGG   REACTION: R05066
Entry
R05066                      Reaction                               
Name
3-hydroxy-2-methylpropanoate:NAD+ oxidoreductase
Definition
(S)-3-Hydroxyisobutyrate + NAD+ <=> (S)-Methylmalonate semialdehyde + NADH + H+
Equation
Reaction class
RC00001  C00003_C00004
RC00099  C06001_C06002
Enzyme
Pathway
rn00280  Valine, leucine and isoleucine degradation
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.31
     R05066  (S)-3-Hydroxyisobutyrate + NAD+ <=> (S)-Methylmalonate semialdehyde + NADH + H+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.1.1.31
   R02047  3-Hydroxy-2-methylpropanoate <=> 2-Methyl-3-oxopropanoate
    R05066  (S)-3-Hydroxyisobutyrate <=> (S)-Methylmalonate semialdehyde
Orthology
K00020  3-hydroxyisobutyrate dehydrogenase [EC:1.1.1.31]
K23146  3-hydroxyisobutyrate/3-hydroxypropionate dehydrogenase [EC:1.1.1.31 1.1.1.59]
Other DBs
RHEA: 31278
LinkDB

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