KEGG   MODULE: M00115
Entry
M00115            Pathway   Module                                 
Name
NAD biosynthesis, aspartate => quinolinate => NAD
Definition
(K00278,K06989) K03517 K00767 (K00969,K06210) (K01916,K01950)
Diagram
M00115

Orthology
K00278  
L-aspartate oxidase [EC:1.4.3.16] [RN:R00481]
K06989  
aspartate dehydrogenase [EC:1.4.1.21] [RN:R07410 R07407]
K03517  
quinolinate synthase [EC:2.5.1.72] [RN:R04292]
K00767  
nicotinate-nucleotide pyrophosphorylase (carboxylating) [EC:2.4.2.19] [RN:R03348]
K00969,K06210  
nicotinate-nucleotide adenylyltransferase [EC:2.7.7.18] [RN:R03005]
K01916  
NAD+ synthase [EC:6.3.1.5] [RN:R00189]
K01950  
NAD+ synthase (glutamine-hydrolysing) [EC:6.3.5.1] [RN:R00257]
Class
Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
Pathway
map00760  Nicotinate and nicotinamide metabolism
map01240  Biosynthesis of cofactors
map01100  Metabolic pathways
Reaction
R00481,R07410,R07407  
R04292  
R03348  
R03005  
R00189,R00257  
Compound
C00049  L-Aspartate
C05840  Iminoaspartate
C03722  Pyridine-2,3-dicarboxylate
C01185  Nicotinate D-ribonucleotide
C00857  Deamino-NAD+
C00003  NAD+
Reference
PMID:11153263
  Authors
Begley TP, Kinsland C, Mehl RA, Osterman A, Dorrestein P
  Title
The biosynthesis of nicotinamide adenine dinucleotides in bacteria.
  Journal
Vitam Horm 61:103-19 (2001)
DOI:10.1016/s0083-6729(01)61003-3
Reference
PMID:16698895
  Authors
Katoh A, Uenohara K, Akita M, Hashimoto T
  Title
Early steps in the biosynthesis of NAD in Arabidopsis start with aspartate and occur in the plastid.
  Journal
Plant Physiol 141:851-7 (2006)
DOI:10.1104/pp.106.081091
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