KEGG   MODULE: M00819
Entry
M00819            Pathway   Module                                 
Name
Pentalenolactone biosynthesis, farnesyl-PP => pentalenolactone
Definition
K12250 K15907 -- K18056 K17747 K18091 K18057 K17476
Diagram
M00819

Orthology
K12250  
pentalenene synthase [EC:4.2.3.7] [RN:R02305]
K15907  
pentalenene oxygenase [EC:1.14.15.32] [RN:R09814]
K18056  
1-deoxypentalenic acid 11beta-hydroxylase [EC:1.14.11.35] [RN:R10157]
K17747  
1-deoxy-11beta-hydroxypentalenate dehydrogenase [EC:1.1.1.340] [RN:R10156]
K18091  
pentalenolactone D synthase [EC:1.14.13.170 1.14.13.171] [RN:R10154]
K18057  
pentalenolactone F synthase [EC:1.14.11.36] [RN:R10145]
K17476  
pentalenolactone synthase [EC:1.14.19.8] [RN:R10162]
Class
Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of other antibiotics
Pathway
map00998  Biosynthesis of various antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R02305  
R09814  
R11315  
R10157  
R10156  
R10154  
R10145  
R10162  
Compound
C00448  trans,trans-Farnesyl diphosphate
C01841  Pentalenene
C19939  Pentalen-13-al
C20404  1-Deoxypentalenate
C20403  1-Deoxy-11beta-hydroxypentalenate
C20400  1-Deoxy-11-oxopentalenate
C20399  Pentalenolactone D
C20397  Pentalenolactone F
C20407  Pentalenolactone
Reference
PMID:17017767
  Authors
Quaderer R, Omura S, Ikeda H, Cane DE
  Title
Pentalenolactone biosynthesis. Molecular cloning and assignment of biochemical function to PtlI, a cytochrome P450 of Streptomyces avermitilis.
  Journal
J Am Chem Soc 128:13036-7 (2006)
DOI:10.1021/ja0639214
Reference
PMID:21250661
  Authors
Seo MJ, Zhu D, Endo S, Ikeda H, Cane DE
  Title
Genome mining in Streptomyces. Elucidation of the role of Baeyer-Villiger monooxygenases and non-heme iron-dependent dehydrogenase/oxygenases in the final steps of the biosynthesis of pentalenolactone and neopentalenolactone.
  Journal
Biochemistry 50:1739-54 (2011)
DOI:10.1021/bi1019786
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