| Entry |
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| Name |
Aurachin biosynthesis, anthranilate => aurachin A
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| Definition |
K09460 K02078+K14245+K14246+K22798 K22799 K22800 K21272 K21271 K22801 K22802
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| Diagram |
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| Orthology |
auaB; acyl carrier protein [RN: R12049] auaC; PKS ketosynthase (KS/KS alpha) [EC:2.3.1.-] [RN: R12049] auaD; PKS chain-length factor (CLF/KS beta) [EC:2.3.1.-] [RN: R12049] auaE; anthranilate-CoA-ACP transferase [EC:6.2.1.-] [RN: R12049] auaA; 2-methyl-4-hydroxyquinoline prenyltransferase [EC:2.5.1.-] [RN: R12050] auaF; aurachin D monooxygenase [EC:1.14.13.-] [RN: R12051] auaJ; aurachin B monooxygenase [EC:1.14.13.-] [RN: R12052 R12053] auaI; aurichin B epoxide hydrolase [RN: R12054] |
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| Class |
Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of other antibiotics
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| Pathway |
| map00998 | Biosynthesis of various antibiotics |
| map01110 | Biosynthesis of secondary metabolites |
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| Reaction |
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| Compound |
| C21141 | 4-Hydroxy-2-methyl-3-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide |
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| Reference |
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| Authors |
Pistorius D, Li Y, Mann S, Muller R |
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| Title |
Unprecedented anthranilate priming involving two enzymes of the acyl adenylating superfamily in aurachin biosynthesis. |
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| Journal |
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| Reference |
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| Authors |
Sandmann A, Dickschat J, Jenke-Kodama H, Kunze B, Dittmann E, Muller R |
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| Title |
A Type II polyketide synthase from the gram-negative Bacterium Stigmatella aurantiaca is involved in Aurachin alkaloid biosynthesis. |
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| Journal |
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| Reference |
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| Authors |
Kitagawa W, Ozaki T, Nishioka T, Yasutake Y, Hata M, Nishiyama M, Kuzuyama T, Tamura T |
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| Title |
Cloning and heterologous expression of the aurachin RE biosynthesis gene cluster afford a new cytochrome P450 for quinoline N-hydroxylation. |
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| Journal |
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| LinkDB |
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