MODULE: M00956
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Entry
M00956 Pathway Module
Name
Lysine degradation, bacteria, L-lysine => succinate
Definition
K01582 K09251 K00137 K07250 K00135 K15737 K15736
Diagram
Orthology
K01582
lysine decarboxylase [EC:
4.1.1.18
] [RN:
R00462
]
K09251
putrescine aminotransferase [EC:
2.6.1.82
] [RN:
R12214
]
K00137
aminobutyraldehyde dehydrogenase [EC:
1.2.1.19
] [RN:
R12215
]
K07250
5-aminovalerate aminotransferase [EC:
2.6.1.48
] [RN:
R02274
]
K00135
glutarate-semialdehyde dehydrogenase [EC:
1.2.1.20
] [RN:
R02401
]
K15737
glutarate dioxygenase [EC:
1.14.11.64
] [RN:
R12216
]
K15736
(S)-2-hydroxyglutarate dehydrogenase [EC:
1.1.5.13
] [RN:
R12217
]
Ortholog table
Taxonomy
Module table
Class
Pathway modules; Amino acid metabolism; Lysine metabolism
BRITE hierarchy
Pathway
map00310
Lysine degradation
map01100
Metabolic pathways
map01120
Microbial metabolism in diverse environments
Reaction
R00462
C00047
->
C01672
R12214
C01672
->
C12455
R12215
C12455
->
C00431
R02274
C00431
->
C03273
R02401
C03273
->
C00489
R12216
C00489
+
C00026
->
C03196
+
C00042
R12217
C03196
->
C00026
Compound
C00047
L-Lysine
C01672
Cadaverine
C12455
5-Aminopentanal
C00431
5-Aminopentanoate
C03273
5-Oxopentanoate
C00489
Glutarate
C00026
2-Oxoglutarate
C03196
(S)-2-Hydroxyglutarate
C00042
Succinate
Reference
PMID:
30498244
Authors
Knorr S, Sinn M, Galetskiy D, Williams RM, Wang C, Muller N, Mayans O, Schleheck D, Hartig JS
Title
Widespread bacterial lysine degradation proceeding via glutarate and L-2-hydroxyglutarate.
Journal
Nat Commun 9:5071 (2018)
DOI:
10.1038/s41467-018-07563-6
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