MODULE: M00963
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Entry
M00963 Pathway Module
Name
Chanoclavine aldehyde biosynthesis, tryptophan => chanoclavine-I aldehyde
Definition
K14130 K18884 K17746
Diagram
Orthology
K14130
tryptophan 4-dimethylallyltransferase [EC:
2.5.1.34
] [RN:
R01657
]
K18884
4-dimethylallyltryptophan N-methyltransferase [EC:
2.1.1.261
] [RN:
R10166
]
K17746
chanoclavine-I dehydrogenase [EC:
1.1.1.332
] [RN:
R10128
]
Ortholog table
Taxonomy
Module table
Class
Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of phytochemical compounds
BRITE hierarchy
Pathway
map00901
Indole alkaloid biosynthesis
map01100
Metabolic pathways
map01110
Biosynthesis of secondary metabolites
Reaction
R01657
C00078
->
C04290
R10166
C04290
->
C20410
R12104
C20410
->
C09131
R10128
C09131
->
C20379
Compound
C00078
L-Tryptophan
C04290
4-(3-Methylbut-2-enyl)-L-tryptophan
C20410
4-Dimethylallyl-L-abrine
C09131
Chanoclavine-I
C20379
Chanoclavine-I aldehyde
Reference
PMID:
22403186
Authors
Wallwey C, Heddergott C, Xie X, Brakhage AA, Li SM
Title
Genome mining reveals the presence of a conserved gene cluster for the biosynthesis of ergot alkaloid precursors in the fungal family Arthrodermataceae.
Journal
Microbiology 158:1634-44 (2012)
DOI:
10.1099/mic.0.056796-0
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