KEGG   MODULE: M00967
Entry
M00967            Pathway   Module                                 
Name
Flavone degradation, luteolin/apigenin => DHCA/phloretate
Definition
K26176 K26178 K22906
Diagram
M00967

Orthology
K26176  
flavone/flavonol reductase [RN:R13069 R13066]
K26178  
flavanone/flavanol-cleaving reductase [RN:R13072 R13073]
K22906  
phloretin hydrolase [EC:3.7.1.4] [RN:R13082 R02901]
Class
Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of phytochemical compounds
Pathway
map00946  Degradation of flavonoids
map01100  Metabolic pathways
Reaction
Compound
C01514  Luteolin
C05631  Eriodictyol
C22567  3-Hydroxyphloretin
C10447  3,4-Dihydroxyphenylpropanoate
C02183  Phloroglucinol
C01477  Apigenin
C00509  Naringenin
C00774  Phloretin
C01744  Phloretate
Reference
  Authors
Yang G, Hong S, Yang P, Sun Y, Wang Y, Zhang P, Jiang W, Gu Y.
  Title
Discovery of an ene-reductase for initiating flavone and flavonol catabolism in gut bacteria.
  Journal
Nat Commun 12:790 (2021)
DOI:10.1038/s41467-021-20974-2
Reference
  Authors
Braune A, Gutschow M, Blaut M.
  Title
An NADH-Dependent Reductase from Eubacterium ramulus Catalyzes the Stereospecific Heteroring Cleavage of Flavanones and Flavanonols.
  Journal
Appl Environ Microbiol 85:e01233-19 (2019)
DOI:10.1128/AEM.01233-19
Reference
  Authors
Schoefer L, Braune A, Blaut M
  Title
Cloning and expression of a phloretin hydrolase gene from Eubacterium ramulus and characterization of the recombinant enzyme.
  Journal
Appl Environ Microbiol 70:6131-7 (2004)
DOI:10.1128/AEM.70.10.6131-6137.2004
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