REACTION: R00940
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Entry
R00940 Reaction
Name
5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase
Definition
Tetrahydrofolate + 2 NADP+ <=> Folate + 2 NADPH + 2 H+
Equation
C00101
+ 2
C00006
<=>
C00504
+ 2
C00005
+ 2
C00080
Comment
two-step reaction (see
R00939+R02236
)
NAD+ (see
R00937
)
Reaction class
RC00001
C00005_C00006
RC00110
C00101_C00504
Enzyme
1.5.1.3
Pathway
rn00670
One carbon pool by folate
rn00790
Folate biosynthesis
rn01100
Metabolic pathways
rn01240
Biosynthesis of cofactors
Brite
Enzymatic reactions [BR:
br08201
]
1. Oxidoreductase reactions
1.5 Acting on the CH-NH group of donors
1.5.1 With NAD+ or NADP+ as acceptor
1.5.1.3
R00940 Tetrahydrofolate + 2 NADP+ <=> Folate + 2 NADPH + 2 H+
BRITE hierarchy
Orthology
K00287
dihydrofolate reductase [EC:
1.5.1.3
]
K13998
dihydrofolate reductase / thymidylate synthase [EC:
1.5.1.3
2.1.1.45
]
K18589
dihydrofolate reductase (trimethoprim resistance protein) [EC:
1.5.1.3
]
K18590
dihydrofolate reductase (trimethoprim resistance protein) [EC:
1.5.1.3
]
K18591
dihydrofolate reductase (trimethoprim resistance protein) [EC:
1.5.1.3
]
K19643
dihydrofolate reductase (trimethoprim resistance protein) [EC:
1.5.1.3
]
K19644
dihydrofolate reductase (trimethoprim resistance protein) [EC:
1.5.1.3
]
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