KEGG   ORTHOLOGY: K18591
Entry
K18591                      KO                                     
Symbol
dfrD, dhfr
Name
dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
Pathway
map00670  One carbon pool by folate
map00790  Folate biosynthesis
map01100  Metabolic pathways
Reaction
R00936  5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
R00937  5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
R00939  5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase
R00940  5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase
R02235  dihydrofolate:NAD+ oxidoreductase
R02236  dihydrofolate:NADP+ oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    K18591  dfrD, dhfr; dihydrofolate reductase (trimethoprim resistance protein)
   00670 One carbon pool by folate
    K18591  dfrD, dhfr; dihydrofolate reductase (trimethoprim resistance protein)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K18591  dfrD, dhfr; dihydrofolate reductase (trimethoprim resistance protein)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     K18591  dfrD, dhfr; dihydrofolate reductase (trimethoprim resistance protein)
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  Trimethoprim resistance genes
   Dihydrofolate reductases
    K18591  dfrD, dhfr; dihydrofolate reductase (trimethoprim resistance protein)
Other DBs
COG: COG0262
GO: 0004146
Genes
NTX: NQZ71_21885(dfr)
ACAI: ISX45_00040(dfr_DGK)
PASA: BAOM_2495(folA)
PSYB: KD050_18595(dfr_DGK)
MLIT: KDJ21_019250(dfr)
MENL: MVE64_25605(dfr)
MEBZ: LPC09_11890(dfr)
BOU: I5818_20160(dfr_DGK)
SUW: SATW20_04710(dfrG)
SAUZ: SAZ172_0405(dfrG)
SHH: ShL2_01296(dfrA_1)
SSD: SPSINT_2038
SARL: SAP2_17960
MLEN: H3V22_04770(dfrG)
PSON: JI735_26100
PPLA: BBI15_15850
EFC: EFAU004_00066(dhfr_2)
ERAF: J9537_20350(dfrG)
VTE: BHY08_08530
JAR: G7057_01175 G7057_02725
JPO: G7058_00790
LGO: JCM16774_1587(folA)
AG: BAE15963(dfrG) CAA90486(dfrD) CAR62505(dfrK)
 » show all
Reference
PMID:19015335
  Authors
Kadlec K, Schwarz S
  Title
Identification of a novel trimethoprim resistance gene, dfrK, in a methicillin-resistant Staphylococcus aureus ST398 strain and its physical linkage to the tetracycline resistance gene tet(L).
  Journal
Antimicrob Agents Chemother 53:776-8 (2009)
DOI:10.1128/AAC.01128-08
Reference
PMID:23162539
  Authors
Roberts MC, Schwarz S, Aarts HJ
  Title
Erratum: Acquired antibiotic resistance genes: an overview.
  Journal
Front Microbiol 3:384 (2012)
DOI:10.3389/fmicb.2012.00384
Reference
PMID:11432417
  Authors
Skold O
  Title
Resistance to trimethoprim and sulfonamides.
  Journal
Vet Res 32:261-73 (2001)
DOI:10.1051/vetres:2001123
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