KEGG   REACTION: R01169
Entry
R01169                      Reaction                               
Name
S-adenosyl-L-methionine:L-histidine Nalpha-methyltransferase
Definition
L-Histidine + 3 S-Adenosyl-L-methionine + H+ <=> Hercynine + 3 S-Adenosyl-L-homocysteine
Equation
C00135 + 3 C00019 + C00080 <=> C05575 + 3 C00021
Comment
three-step reaction (see R10523+R10524+R04436)
Reaction class
RC00003  C00019_C00021
RC02308  C00135_C05575
Enzyme
2.1.1.44
Pathway
rn00340  Histidine metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.44
     R01169  L-Histidine + 3 S-Adenosyl-L-methionine + H+ <=> Hercynine + 3 S-Adenosyl-L-homocysteine
Orthology
K18911  L-histidine Nalpha-methyltransferase [EC:2.1.1.44]
K20246  L-histidine Nalpha-methyltransferase / hercynylcysteine S-oxide synthase [EC:2.1.1.44 1.21.3.10]
Reference
1  [PMID:5484456]
  Authors
Ishikawa Y, Melville DB.
  Title
The enzymatic alpha-N-methylation of histidine.
  Journal
J Biol Chem 245:5967-73 (1970)
DOI:10.1016/S0021-9258(18)62649-3
Other DBs
RHEA: 38474
LinkDB

KEGG   REACTION: R10523
Entry
R10523                      Reaction                               
Name
S-adenosyl-L-methionine:L-histidine Nalpha-methyltransferase
Definition
S-Adenosyl-L-methionine + L-Histidine <=> S-Adenosyl-L-homocysteine + Nalpha-Methylhistidine
Equation
C00019 + C00135 <=> C00021 + C03298
Comment
first step of three-step reaction (see R01169, R10523+R10524+R04436)
Reaction class
RC00003  C00019_C00021
RC00190  C00135_C03298
Enzyme
2.1.1.44
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.44
     R10523  S-Adenosyl-L-methionine + L-Histidine <=> S-Adenosyl-L-homocysteine + Nalpha-Methylhistidine
Other DBs
RHEA: 38478
LinkDB

KEGG   REACTION: R10524
Entry
R10524                      Reaction                               
Name
S-adenosyl-L-methionine:Nalpha-methyl-L-histidine Nalpha-methyltransferase
Definition
S-Adenosyl-L-methionine + Nalpha-Methylhistidine <=> S-Adenosyl-L-homocysteine + N,N-Dimethylhistidine
Equation
C00019 + C03298 <=> C00021 + C04259
Comment
second step of three-step reaction (see R01169, R10523+R10524+R04436)
Reaction class
RC00003  C00019_C00021
RC02136  C03298_C04259
Enzyme
2.1.1.44
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.44
     R10524  S-Adenosyl-L-methionine + Nalpha-Methylhistidine <=> S-Adenosyl-L-homocysteine + N,N-Dimethylhistidine
Other DBs
RHEA: 38482
LinkDB

KEGG   REACTION: R04436
Entry
R04436                      Reaction                               
Name
S-adenosyl-L-methionine:Nalpha,Nalpha-dimethyl-L-histidine Nalpha-methyltransferase
Definition
S-Adenosyl-L-methionine + N,N-Dimethylhistidine <=> S-Adenosyl-L-homocysteine + Hercynine
Equation
C00019 + C04259 <=> C00021 + C05575
Comment
last step of three-step reaction (see R01169, R10523+R10524+R04436)
Reaction class
RC00003  C00019_C00021
RC01155  C04259_C05575
Enzyme
2.1.1.44
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.44
     R04436  S-Adenosyl-L-methionine + N,N-Dimethylhistidine <=> S-Adenosyl-L-homocysteine + Hercynine
Other DBs
RHEA: 11107
LinkDB

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