REACTION: R01813
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Entry
R01813 Reaction
Name
tetrahydrobiopterin:NADP+ oxidoreductase
Definition
Tetrahydrobiopterin + NADP+ <=> 6-Lactoyl-5,6,7,8-tetrahydropterin + NADPH + H+
Equation
C00272
+
C00006
<=>
C04244
+
C00005
+
C00080
Comment
a part of three-step reaction (see
R08208, R01813+R11762+R11763
)
Reaction class
RC00001
C00005_C00006
RC00602
C00272_C04244
Enzyme
1.1.1.153
Pathway
rn00790
Folate biosynthesis
rn01100
Metabolic pathways
Brite
Enzymatic reactions [BR:
br08201
]
1. Oxidoreductase reactions
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.153
R01813 Tetrahydrobiopterin + NADP+ <=> 6-Lactoyl-5,6,7,8-tetrahydropterin + NADPH + H+
BRITE hierarchy
Orthology
K00072
sepiapterin reductase [EC:
1.1.1.153
]
Reference
1 [PMID:
21867484
]
Authors
Werner ER, Blau N, Thony B
Title
Tetrahydrobiopterin: biochemistry and pathophysiology.
Journal
Biochem J 438:397-414 (2011)
DOI:
10.1042/BJ20110293
Reference
2 [PMID:
9405351
]
Authors
Auerbach G, Herrmann A, Gutlich M, Fischer M, Jacob U, Bacher A, Huber R.
Title
The 1.25 A crystal structure of sepiapterin reductase reveals its binding mode to pterins and brain neurotransmitters.
Journal
EMBO J 16:7219-30 (1997)
DOI:
10.1093/emboj/16.24.7219
Other DBs
RHEA:
42503
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