KEGG   REACTION: R08208
Entry
R08208                      Reaction                               
Name
tetrahydrobiopterin:NADP+ oxidoreductase (6-pyruvoyltetrahydropterin-forming)
Definition
Tetrahydrobiopterin + 2 NADP+ <=> 6-Pyruvoyltetrahydropterin + 2 NADPH + 2 H+
Equation
C00272 + 2 C00006 <=> C03684 + 2 C00005 + 2 C00080
Comment
three-step reaction (see R01813+R11762+R11763)
Reaction class
RC00001  C00005_C00006
RC02162  C00272_C03684
Enzyme
1.1.1.153
Pathway
rn00790  Folate biosynthesis
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Module
M00842  Tetrahydrobiopterin biosynthesis, GTP => BH4
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.153
     R08208  Tetrahydrobiopterin + 2 NADP+ <=> 6-Pyruvoyltetrahydropterin + 2 NADPH + 2 H+
Orthology
K00072  sepiapterin reductase [EC:1.1.1.153]
Reference
1  [PMID:21867484]
  Authors
Werner ER, Blau N, Thony B
  Title
Tetrahydrobiopterin: biochemistry and pathophysiology.
  Journal
Biochem J 438:397-414 (2011)
DOI:10.1042/BJ20110293
Reference
2  [PMID:9405351]
  Authors
Auerbach G, Herrmann A, Gutlich M, Fischer M, Jacob U, Bacher A, Huber R.
  Title
The 1.25 A crystal structure of sepiapterin reductase reveals its binding mode to pterins and brain neurotransmitters.
  Journal
EMBO J 16:7219-30 (1997)
DOI:10.1093/emboj/16.24.7219
Other DBs
RHEA: 32630
LinkDB

KEGG   REACTION: R01813
Entry
R01813                      Reaction                               
Name
tetrahydrobiopterin:NADP+ oxidoreductase
Definition
Tetrahydrobiopterin + NADP+ <=> 6-Lactoyl-5,6,7,8-tetrahydropterin + NADPH + H+
Equation
C00272 + C00006 <=> C04244 + C00005 + C00080
Comment
a part of three-step reaction (see R08208, R01813+R11762+R11763)
Reaction class
RC00001  C00005_C00006
RC00602  C00272_C04244
Enzyme
1.1.1.153
Pathway
rn00790  Folate biosynthesis
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.153
     R01813  Tetrahydrobiopterin + NADP+ <=> 6-Lactoyl-5,6,7,8-tetrahydropterin + NADPH + H+
Orthology
K00072  sepiapterin reductase [EC:1.1.1.153]
Reference
1  [PMID:21867484]
  Authors
Werner ER, Blau N, Thony B
  Title
Tetrahydrobiopterin: biochemistry and pathophysiology.
  Journal
Biochem J 438:397-414 (2011)
DOI:10.1042/BJ20110293
Reference
2  [PMID:9405351]
  Authors
Auerbach G, Herrmann A, Gutlich M, Fischer M, Jacob U, Bacher A, Huber R.
  Title
The 1.25 A crystal structure of sepiapterin reductase reveals its binding mode to pterins and brain neurotransmitters.
  Journal
EMBO J 16:7219-30 (1997)
DOI:10.1093/emboj/16.24.7219
Other DBs
RHEA: 42503
LinkDB

KEGG   REACTION: R11762
Entry
R11762                      Reaction                               
Definition
6-Lactoyl-5,6,7,8-tetrahydropterin <=> 6-(1'-Hydroxy-2'-oxopropyl)-tetrahydropterin
Equation
C04244 <=> C21640
Comment
a part of three-step reaction (see R08208, R01813+R11762+R11763)
isomerization
Reaction class
RC03490  C04244_C21640
Enzyme
1.1.1.153
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.153
     R11762  6-Lactoyl-5,6,7,8-tetrahydropterin <=> 6-(1'-Hydroxy-2'-oxopropyl)-tetrahydropterin
Orthology
K00072  sepiapterin reductase [EC:1.1.1.153]
Reference
1  [PMID:21867484]
  Authors
Werner ER, Blau N, Thony B
  Title
Tetrahydrobiopterin: biochemistry and pathophysiology.
  Journal
Biochem J 438:397-414 (2011)
DOI:10.1042/BJ20110293
Reference
2  [PMID:9405351]
  Authors
Auerbach G, Herrmann A, Gutlich M, Fischer M, Jacob U, Bacher A, Huber R.
  Title
The 1.25 A crystal structure of sepiapterin reductase reveals its binding mode to pterins and brain neurotransmitters.
  Journal
EMBO J 16:7219-30 (1997)
DOI:10.1093/emboj/16.24.7219
LinkDB

KEGG   REACTION: R11763
Entry
R11763                      Reaction                               
Name
6-(1'-hydroxy-2'-oxopropyl)-tetrahydropterin:NADP+ oxidoreductase
Definition
6-(1'-Hydroxy-2'-oxopropyl)-tetrahydropterin + NADP+ <=> 6-Pyruvoyltetrahydropterin + NADPH + H+
Equation
C21640 + C00006 <=> C03684 + C00005 + C00080
Comment
a part of three-step reaction (see R08208, R01813+R11762+R11763)
Reaction class
RC03491  C03684_C21640
Enzyme
1.1.1.153       1.1.1.213
Pathway
rn00790  Folate biosynthesis
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.153
     R11763  6-(1'-Hydroxy-2'-oxopropyl)-tetrahydropterin + NADP+ <=> 6-Pyruvoyltetrahydropterin + NADPH + H+
    1.1.1.213
     R11763  6-(1'-Hydroxy-2'-oxopropyl)-tetrahydropterin + NADP+ <=> 6-Pyruvoyltetrahydropterin + NADPH + H+
Orthology
K00072  sepiapterin reductase [EC:1.1.1.153]
K04119  aldo-keto reductase family 1 member C3 [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
Reference
1  [PMID:21867484]
  Authors
Werner ER, Blau N, Thony B
  Title
Tetrahydrobiopterin: biochemistry and pathophysiology.
  Journal
Biochem J 438:397-414 (2011)
DOI:10.1042/BJ20110293
Reference
2  [PMID:9405351]
  Authors
Auerbach G, Herrmann A, Gutlich M, Fischer M, Jacob U, Bacher A, Huber R.
  Title
The 1.25 A crystal structure of sepiapterin reductase reveals its binding mode to pterins and brain neurotransmitters.
  Journal
EMBO J 16:7219-30 (1997)
DOI:10.1093/emboj/16.24.7219
LinkDB

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