KEGG   REACTION: R01840
Entry
R01840                      Reaction                               
Name
androstenedione,NADPH---hemoprotein reductase:oxygen oxidoreductase (19-hydroxylating)
Definition
Androstenedione + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 19-Hydroxyandrost-4-ene-3,17-dione + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C00280 + C03024 + C00007 <=> C05290 + C03161 + C00001
Comment
aromatase, ARO
three successive reactions (R01840+R04759+R02351)
subsequently R04759
Reaction class
RC00257  C00280_C05290
Enzyme
1.14.14.14
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.14
     R01840  Androstenedione + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 19-Hydroxyandrost-4-ene-3,17-dione + [Oxidized NADPH---hemoprotein reductase] + H2O
Orthology
K07434  aromatase [EC:1.14.14.14]
Other DBs
RHEA: 38202
LinkDB

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