KEGG   REACTION: R01840
Entry
R01840                      Reaction                               
Name
androstenedione,NADPH---hemoprotein reductase:oxygen oxidoreductase (19-hydroxylating)
Definition
Androstenedione + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 19-Hydroxyandrost-4-ene-3,17-dione + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C00280 + C03024 + C00007 <=> C05290 + C03161 + C00001
Comment
aromatase, ARO
three successive reactions (R01840+R04759+R02351)
subsequently R04759
Reaction class
RC00257  C00280_C05290
Enzyme
1.14.14.14
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.14
     R01840  Androstenedione + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 19-Hydroxyandrost-4-ene-3,17-dione + [Oxidized NADPH---hemoprotein reductase] + H2O
Orthology
K07434  aromatase [EC:1.14.14.14]
Other DBs
RHEA: 38202
LinkDB

KEGG   REACTION: R04759
Entry
R04759                      Reaction                               
Name
19-hydroxyandrostenedione,NADPH---hemoprotein reductase:oxygen 19-oxidoreductase
Definition
19-Hydroxyandrost-4-ene-3,17-dione + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 19-Oxoandrost-4-ene-3,17-dione + [Oxidized NADPH---hemoprotein reductase] + 2 H2O
Equation
C05290 + C03024 + C00007 <=> C05297 + C03161 + 2 C00001
Comment
aromatase, ARO
following after R01840
subsequently R02351
Reaction class
RC00893  C05290_C05297
Enzyme
1.14.14.14
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.14
     R04759  19-Hydroxyandrost-4-ene-3,17-dione + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 19-Oxoandrost-4-ene-3,17-dione + [Oxidized NADPH---hemoprotein reductase] + 2 H2O
Orthology
K07434  aromatase [EC:1.14.14.14]
Other DBs
RHEA: 38206
LinkDB

KEGG   REACTION: R02351
Entry
R02351                      Reaction                               
Name
19-oxoandrostenedione,NADPH---hemoprotein reductase:oxygen oxidoreductase (aromatizing, formate-forming)
Definition
19-Oxoandrost-4-ene-3,17-dione + Oxygen + [Reduced NADPH---hemoprotein reductase] <=> Estrone + Formate + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C05297 + C00007 + C03024 <=> C00468 + C00058 + C03161 + C00001
Comment
aromatase, ARO
following after R04759
Reaction class
RC02649  C00468_C05297
Enzyme
1.14.14.14
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.14
     R02351  19-Oxoandrost-4-ene-3,17-dione + Oxygen + [Reduced NADPH---hemoprotein reductase] <=> Estrone + Formate + [Oxidized NADPH---hemoprotein reductase] + H2O
Orthology
K07434  aromatase [EC:1.14.14.14]
Other DBs
RHEA: 38210
LinkDB

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