KEGG   REACTION: R02685
Entry
R02685                      Reaction                               
Name
(3S)-3-hydroxyacyl-CoA hydro-lyase
Definition
(3S)-3-Hydroxyacyl-CoA <=> trans-2,3-Dehydroacyl-CoA + H2O
Equation
C00640 <=> C00658 + C00001
Reaction class
RC00770  C00640_C00658
Enzyme
4.2.1.17        4.2.1.74
Pathway
rn00062  Fatty acid elongation
Module
M00085  Fatty acid elongation in mitochondria
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.17
     R02685  (3S)-3-Hydroxyacyl-CoA <=> trans-2,3-Dehydroacyl-CoA + H2O
    4.2.1.74
     R02685  (3S)-3-Hydroxyacyl-CoA <=> trans-2,3-Dehydroacyl-CoA + H2O
IUBMB reaction hierarchy [BR:br08202]
 4. Lyase reactions
  4.2.1.17
   R02685  (3S)-3-Hydroxyacyl-CoA <=> trans-2,3-Dehydroacyl-CoA
  4.2.1.74
   R02685  (3S)-3-Hydroxyacyl-CoA <=> trans-2,3-Dehydroacyl-CoA
Orthology
K07511  enoyl-CoA hydratase [EC:4.2.1.17]
K07515  enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211]
Other DBs
RHEA: 16108
LinkDB

KEGG   REACTION: R01778
Entry
R01778                      Reaction                               
Name
(3S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase
Definition
(3S)-3-Hydroxyacyl-CoA + NAD+ <=> 3-Oxoacyl-CoA + NADH + H+
Equation
C00640 + C00003 <=> C00264 + C00004 + C00080
Comment
general reaction
the enzyme ec 1.1.1.35 has broad specificity to acyl chain-length, while ec 1.1.1.211 is long-chain specific
Reaction class
RC00001  C00003_C00004
RC00103  C00264_C00640
Enzyme
1.1.1.35        1.1.1.211
Pathway
rn00062  Fatty acid elongation
Module
M00085  Fatty acid elongation in mitochondria
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.35
     R01778  (3S)-3-Hydroxyacyl-CoA + NAD+ <=> 3-Oxoacyl-CoA + NADH + H+
    1.1.1.211
     R01778  (3S)-3-Hydroxyacyl-CoA + NAD+ <=> 3-Oxoacyl-CoA + NADH + H+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.1.1.35
   R01778  (3S)-3-Hydroxyacyl-CoA <=> 3-Oxoacyl-CoA
  1.1.1.211
   R01778  (3S)-3-Hydroxyacyl-CoA <=> 3-Oxoacyl-CoA
Orthology
K00022  3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K07515  enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211]
Other DBs
RHEA: 22435
LinkDB

KEGG   REACTION: R00391
Entry
R00391                      Reaction                               
Name
acyl-CoA:acetyl-CoA C-acyltransferase
Definition
Acyl-CoA + Acetyl-CoA <=> CoA + 3-Oxoacyl-CoA
Equation
C00040 + C00024 <=> C00010 + C00264
Comment
general reaction
Reaction class
RC00004  C00010_C00040
RC00326  C00024_C00264
RC02997  C00040_C00264
Enzyme
2.3.1.16
Pathway
rn00062  Fatty acid elongation
Module
M00085  Fatty acid elongation in mitochondria
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.16
     R00391  Acyl-CoA + Acetyl-CoA <=> CoA + 3-Oxoacyl-CoA
IUBMB reaction hierarchy [BR:br08202]
 2. Transferase reactions
  2.3.1.16
   R00391  Acyl-CoA <=> 3-Oxoacyl-CoA
Orthology
K07508  acetyl-CoA acyltransferase 2 [EC:2.3.1.16]
K07509  acetyl-CoA acyltransferase [EC:2.3.1.16]
Other DBs
RHEA: 21567
LinkDB

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