KEGG   REACTION: R02810
Entry
R02810                      Reaction                               
Name
iodide:hydrogen-peroxide oxidoreductase
Definition
2 Iodide + Hydrogen peroxide + 2 H+ <=> Iodine + 2 H2O
Equation
2 C00708 + C00027 + 2 C00080 <=> C01382 + 2 C00001
Comment
thyroid peroxidase, TPO
multi-step reaction on thyroglobulin [KO:K10809] (see R02810+R08520+R08521+R08522+R08523)
Reaction class
RC00783  C00708_C01382
Enzyme
1.11.1.8
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.11  Acting on a peroxide as acceptor
   1.11.1  Peroxidases
    1.11.1.8
     R02810  2 Iodide + Hydrogen peroxide + 2 H+ <=> Iodine + 2 H2O
Other DBs
RHEA: 23339
LinkDB

KEGG   REACTION: R08520
Entry
R08520                      Reaction                               
Definition
[Thyroglobulin]-L-tyrosine + Iodine <=> [Thyroglobulin]-3-iodo-L-tyrosine + Hydroiodic acid
Equation
C16733 + C01382 <=> C16732 + C05590
Comment
thyroid peroxidase, TPO
following after R02810
subsequently R08521 or R08522
Reaction class
RC00949  C16732_C16733
Enzyme
1.11.1.8
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.11  Acting on a peroxide as acceptor
   1.11.1  Peroxidases
    1.11.1.8
     R08520  [Thyroglobulin]-L-tyrosine + Iodine <=> [Thyroglobulin]-3-iodo-L-tyrosine + Hydroiodic acid
LinkDB

KEGG   REACTION: R08521
Entry
R08521                      Reaction                               
Definition
[Thyroglobulin]-3-iodo-L-tyrosine + Iodine <=> [Thyroglobulin]-3,5-diiodo-L-tyrosine + Hydroiodic acid
Equation
C16732 + C01382 <=> C16731 + C05590
Comment
thyroid peroxidase, TPO
following after R02810 and R08520
subsequently R08522 or R08523
Reaction class
RC00949  C16731_C16732
Enzyme
1.11.1.8
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.11  Acting on a peroxide as acceptor
   1.11.1  Peroxidases
    1.11.1.8
     R08521  [Thyroglobulin]-3-iodo-L-tyrosine + Iodine <=> [Thyroglobulin]-3,5-diiodo-L-tyrosine + Hydroiodic acid
LinkDB

KEGG   REACTION: R08522
Entry
R08522                      Reaction                               
Definition
[Thyroglobulin]-3,5-diiodo-L-tyrosine + [Thyroglobulin]-3-iodo-L-tyrosine + Hydrogen peroxide <=> Thyroglobulin triiodothyronine + Thyroglobulin dehydroalanine + 2 H2O
Equation
C16731 + C16732 + C00027 <=> C16730 + C16734 + 2 C00001
Comment
thyroid peroxidase, TPO
following after R08520 and R08521
Reaction class
RC00878  C16730_C16731
RC02138  C16732_C16734
Enzyme
1.11.1.8
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.11  Acting on a peroxide as acceptor
   1.11.1  Peroxidases
    1.11.1.8
     R08522  [Thyroglobulin]-3,5-diiodo-L-tyrosine + [Thyroglobulin]-3-iodo-L-tyrosine + Hydrogen peroxide <=> Thyroglobulin triiodothyronine + Thyroglobulin dehydroalanine + 2 H2O
Other DBs
RHEA: 48971
LinkDB

KEGG   REACTION: R08523
Entry
R08523                      Reaction                               
Definition
2 [Thyroglobulin]-3,5-diiodo-L-tyrosine + Hydrogen peroxide <=> [Thyroglobulin]-L-thyroxine + Thyroglobulin dehydroalanine + 2 H2O
Equation
2 C16731 + C00027 <=> C16729 + C16734 + 2 C00001
Comment
thyroid peroxidase, TPO
following after R08521
Reaction class
RC00878  C16729_C16731
RC02138  C16731_C16734
Enzyme
1.11.1.8
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.11  Acting on a peroxide as acceptor
   1.11.1  Peroxidases
    1.11.1.8
     R08523  2 [Thyroglobulin]-3,5-diiodo-L-tyrosine + Hydrogen peroxide <=> [Thyroglobulin]-L-thyroxine + Thyroglobulin dehydroalanine + 2 H2O
Other DBs
RHEA: 48967
LinkDB

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